Die sonographische Früherkennung des Mammakarzinoms

Kieback, Dirk G.; Kieback, C. C.; Pfeiffer, K. H.

doi:10.1007/978-3-642-72777-1_125

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…Bray et al predicted from demographic trends based on United Nations estimations that 22.2 million new cancer cases will occur by 2030 [3]. Early detection of malignant tumors is important as it improves the chance of recovery from the disease [4]. Tissue changes due to cancer can be identified noninvasively by imaging techniques such as computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI) and optical imaging.…”

Section: Introductionmentioning

confidence: 99%

“…The advantage of optical imaging is that it does not use ionizing radiation or expensive equipment and does not entail high operating and maintenance costs, unlike CT, PET or MRI [5–7]. Optical imaging provides a highly sensitive and cost-effective imaging technique for use with tissues and diseases and is therefore worth exploring further [4,7–11]. In particular, fluorescence imaging is a highly sensitive and functional imaging process that enables high contrast enhancement between tumors and the surrounding healthy tissue [8–12].…”

Section: Introductionmentioning

confidence: 99%

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Noncontact recognition of fluorescently labeled objects in deep tissue via a novel optical light beam arrangement

Hien¹,

Pretze²,

Braun³

et al. 2018

PLoS ONE

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To date, few optical imaging systems are available in clinical practice to perform noninvasive measurements transcutaneously. Instead, functional imaging is performed using ionizing radiation or intense magnetic fields in most cases. The applicability of fluorescence imaging (e.g., for the detection of fluorescently labeled objects, such as tumors) is limited due to the restricted tissue penetration of light and the required long exposure time. Thus, the development of highly sensitive and easily manageable instruments is necessary to broaden the utility of optical imaging. To advance these developments, an improved fluorescence imaging system was designed in this study that operates on the principle of noncontact laser-induced fluorescence and enables the detection of fluorescence from deeper tissue layers as well as real-time imaging. The high performance of the developed optical laser scanner results from the combination of specific point illumination, an intensified charge-coupled device (ICCD) detector with a novel light trap, and a filtering strategy. The suitability of the laser scanner was demonstrated in two representative applications and an in vivo evaluation. In addition, a comparison with a planar imaging system was performed. The results show that the exposure time with the developed laser scanner can be reduced to a few milliseconds during measurements with a penetration depth of up to 32 mm. Due to these short exposure times, real-time fluorescence imaging can be easily achieved. The ability to measure fluorescence from deep tissue layers enables clinically relevant applications, such as the detection of fluorescently labeled malignant tumors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Noncontact recognition of fluorescently labeled objects in deep tissue via a novel optical light beam arrangement

Hien¹,

Pretze²,

Braun³

et al. 2018

PLoS ONE

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show abstract

“…4 von 89 invasiven Karzinomen waren mammographisch und klinisch stumm und wurden bei der Untersuchung von Risikopatientinnen ausschlieNich sonographisch entdeckt [3]. Die Kombination sonographischer Merkmale steigert die Sicherheit der Vorhersage des Karzinoms bei gleichzeitigem Auftreten von Inhomogenitfit, Randunsch/irfe und echodichtem Randsaum bis auf 90%.…”

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Was trägt die Mammasonographie zur Therapieplanung beim Mammakarzinom bei?

Kieback

Köppe

et al. 1989

Arch Gynecol Obstet

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Die sonographische Früherkennung des Mammakarzinoms

Cited by 2 publications

References 2 publications

Noncontact recognition of fluorescently labeled objects in deep tissue via a novel optical light beam arrangement

Noncontact recognition of fluorescently labeled objects in deep tissue via a novel optical light beam arrangement

Was trägt die Mammasonographie zur Therapieplanung beim Mammakarzinom bei?

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