Die sympathische Aktivität bei terminaler Niereninsuffizienz und Nierentransplantation

Lang, R.; Michels, J.H.; Becker-Berke, R.; Lukowski, K.J.; Vlaho, V.; Grundmann, R

doi:10.1007/bf01711725

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…These measurements have been carried out mainly by radioimmunoassay, and the results appear to be contradictory with respect to plasma NE concentration in patients on either HD or CAPD. Differences in NE plasma levels varied from 300 – 400 pg/mL (6,15), and up to 1300 – 1400 pg/mL (5). In the early 1990s, radioimmunoassay was replaced by a new, more accurate technique, HPLC.…”

Section: Discussionmentioning

confidence: 99%

“…These results are probably due to the different methods used for the measurement of plasma catecholamines. Epinephrine and dopamine plasma concentrations have been found to be in the normal range in HD and CAPD patients (5,6).…”

mentioning

confidence: 99%

“…Researchers have also approached the issue of the autonomic system disorder by studying the major bio-logical products of the sympathetic system, that is, catecholamines (5)(6)(7). Catecholamines are synthesized from tyrosine via the following biosynthetic pathway: tyrosine → dihydroxyphenylalanine → dopamine → norepinephrine (NE) → epinephrine (8).…”

mentioning

confidence: 99%

“…Contradictory results have been reported concerning the plasma levels of catecholamines in renal patients on dialysis. Elevated NE plasma levels have been found in patients on hemodialysis (HD) and in patients on CAPD (5). Some authors have reported elevated plasma NE only before HD; levels decreased after the dialysis session (6).…”

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confidence: 99%

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Continuous Ambulatory Peritoneal Dialysis is Responsible for an Increase in Plasma Norepinephrine

et al. 2000

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Objective To investigate the reason for increasing norepinephrine (NE) levels reported in continuous ambulatory peritoneal dialysis (CAPD) patients. Methods Norepinephrine was measured in the plasma and peritoneal dialysate of CAPD patients ( n = 22) and in the plasma and the urine of healthy subjects ( n = 20). It was also measured in the plasma of patients with chronic renal failure (CRF) ( n = 15) and patients on hemodialysis (HD) ( n = 15). Results It was found that NE was increased in CAPD patients compared with healthy individuals (687 ± 221 pg/mL vs 199 ± 25 pg/mL, p < 0.01). The daily removal of NE from the peritoneum of CAPD patients was lower compared with the amount of NE excreted in the urine of healthy subjects. Plasma NE increased after infusion of peritoneal dialysate. In 15 new patients on CAPD, it was found that NE plasma levels increased from 329 ± 67 pg/mL before initiation of dialysis, to 584 ± 173 pg/mL after 12 months of treatment ( p < 0.01). Finally, plasma NE in CAPD patients (687 ± 221 pg/mL) was significantly higher compared with the already increased levels in patients on HD or with CRF (406 ± 143 pg/mL and 378 ± 142 pg/mL, respectively). Conclusions It is concluded that CAPD in patients with end-stage renal disease is responsible for a progressive increase of plasma norepinephrine.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Continuous Ambulatory Peritoneal Dialysis is Responsible for an Increase in Plasma Norepinephrine

et al. 2000

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“…Jacob et al carried out their study on subjects immediately post-transplantation. There is a higher level of circulating hormones and neuropeptides, especially noradrenaline, immediately post-surgery and these could have an effect on the response of the renal blood flow to PEEP [29]. Secondly, their results may have been affected by anaesthetic agents and by the continuous infusion of dopamine given during the transplant surgery [30].…”

Section: Discussionmentioning

confidence: 99%

The effect of continuous positive airway pressure (CPAP) on renal vascular resistance: the influence of renal denervation

et al. 1999

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Objective: To non-invasively study the effects of continuous positive airway pressure breathing (CPAP) on renal vascular resistance in normal subjects and renal allograft recipients, in other words those with with denervated kidneys. We could then ascertain the influence of renal innervation on any resulting changes in renal haemodynamics. Methods:Ten healthy volunteers and six renal transplant patients were studied. Using Doppler ultrasonography, the pulsatility index (PI), an index of renovascular resistance, was measured at incremental levels of CPAP (0, 2.5, 5.0 and 7.5 cmH 2 O). Results:In both groups, the PI increased significantly between 0 and 5.0 cmH 2 O CPAP, with a further increase at 7.5 cmH 2 O CPAP. Conclusions:We found that CPAP at 5.0 and 7.5 cmH 2 O caused a significant increase in renovascular resistance in both normal and renal transplant patients. There was no difference in the degree of rise in renovascular resistance between both groups, indicating that the renal nerves do not play a role in altering renal vascular resistance with the application of CPAP.

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Plasma- und Urin-Katecholamine bei einer 7 Tage überlebten Parathion-Intoxikation

et al. 1990

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During the intensive medical treatment of a finally fatal parathion poisoning (survival time 7 days) with shock symptoms (lung and kidney) the kinetic profiles of both plasma and urinary catecholamines were taken up. In addition the parathion concentrations of the same plasma samples were measured. There could have been found plasma catecholamine profiles exhibiting peak concentrations in the initial phase, followed by a period of 4 days without any detectable plasma epinephrine and finally an extreme elevation of both catecholamines in the last period before death. The excretion patterns confirmed the plasma results. Imaginable pathophysiological mechanisms in consideration of the shock induced renal insufficiency are discussed. The question is raised whether the kinetics of plasma catecholamines may be a possible marker for the prognosis of organophosphate poisoning.

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Die sympathische Aktivität bei terminaler Niereninsuffizienz und Nierentransplantation

Cited by 4 publications

References 31 publications

Continuous Ambulatory Peritoneal Dialysis is Responsible for an Increase in Plasma Norepinephrine

Continuous Ambulatory Peritoneal Dialysis is Responsible for an Increase in Plasma Norepinephrine

The effect of continuous positive airway pressure (CPAP) on renal vascular resistance: the influence of renal denervation

Plasma- und Urin-Katecholamine bei einer 7 Tage überlebten Parathion-Intoxikation

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