Die Tumorverdopplungszeit, ihre röntgenologische Bestimmung und ihre Bedeutung für die Röntgendiagnostik

The tumor doubling times were determined in 142 rounded pulmonary lesions of 78 patients (13 bronchial carcinomas, 7 benign pulmonary tumors, and 122 pulmonary metastases). They varied between +12 and +8863 days of tumor growth and of -1810 days of decrease in tumor mass. Forty-four percent of all pulmonary metastases doubled their volume within 60 to 250 days. The growth rates during the period of observation varied greatly in several pulmonary metastases of the same patient, even for the same solitary circular lung focus of the same person. There is no relationship between tumor doubling time and histological type of the tumor, nor between the interval between operative removal of the primary tumor and the occurrence of pulmonary metastases. In patients between the ages of 10 and 30 years only rapidly growing pulmonary metastases with a tumor doubling time of less than 60 days could be found; even though there is no proved relationship between growth rate and age. The tumor doubling time gives no useful information on the nature of a circular lung focus, and there are no clinical consequences for diagnosis.

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“…Gerstenberg [8]. By this method the diameters of pulmonary lesions that have a circular projection in a two dimensional x-ray are determined.…”

Section: Methods Of Calculating the Tumor Doubling Timementioning

confidence: 99%

“…They assumed an exponential tumor growth and introduced the tumor doubling time (tD) as the period of time during which a tumor doubles its volume. Gerstenberg [8] developed a slide rule for easy calculation of the growth rate, using the measured diameters of the observed circular shadows in the x-ray within a certain period of time.…”

Section: Introductionmentioning

confidence: 99%

Are growth rates of tumors of any clinical importance?

Mühe

Gall

Angermann

1981

Med. Pediatr. Oncol.

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Growth of seventy-eight recurrent mammary cancers:Quantitative study

Philippe¹,

Gal²

1968

Cancer

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Evaluation of the prognosis for small hepatocellular carcinoma based on tumor volume doubling time. A preliminary report

Okazaki¹,

Matsuo²,

Yoshida³

et al. 1989

Cancer

105

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The relationship of tumor volume doubling time to length of patient survival was investigated for 15 patients with small hepatocellular carcinoma smaller than 4.5 cm in diameter. The mean tumor volume doubling time of these 15 nodules was 102 +/- 77 days (mean +/- SD; range 41 to 305 days) before the initiation of a specific treatment for cancer. These doubling times tended to correlate with mitotic indexes of the tumors and the patients could be divided into two groups according to the therapeutic modalities used. Patients in Group A received systemic chemotherapy without response or nonspecific treatments for cancer. In this group, there was a positive correlation between tumor volume doubling time and survival length (r = 0.8812; P less than 0.025). Patients in Group B either received hepatectomy after transarterial embolization or systemic chemotherapy or received hepatectomy alone. In this group, early death occurred in patients who had shorter tumor volume doubling times. Three surgically treated patients in Group B were evaluated as having survived for a significantly long period as assessed from their tumor volume doubling times. These results indicate that tumor volume doubling time is one of the determining factors of survival length in patients with hepatocellular carcinoma, and, therefore, can be used in the evaluation of therapeutic efficacy.

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Die Tumorverdopplungszeit, ihre röntgenologische Bestimmung und ihre Bedeutung für die Röntgendiagnostik

Cited by 15 publications

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Are growth rates of tumors of any clinical importance?

Are growth rates of tumors of any clinical importance?

Growth of seventy-eight recurrent mammary cancers:Quantitative study

Evaluation of the prognosis for small hepatocellular carcinoma based on tumor volume doubling time. A preliminary report

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