Die Varizellenimpfung in Deutschland

Hecht, Jane; Rieck, Thorsten; Tolksdorf, Kristin; Hengel, Hartmut

doi:10.1007/s00103-013-1789-z

Cited by 22 publications

(9 citation statements)

References 24 publications

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“…7,8,15 Our analysis showed that the burden of varicella-related disease has been reduced by about 40% overall, with an even greater decrease of about 60% in children below 5 y of age. Table 1.…”

Section: Discussionmentioning

confidence: 73%

“…15 Hospital diagnosis of varicella and herpes zoster may be regarded as an indicator of severe cases; therefore, it may serve as a further baseline for assumptions on the burden of disease. Data on the main diagnoses of hospital admissions coded according to the International Statistical Classification of Diseases and Related Health Problems (ICD) are available at the German Federal Statistical Office.…”

Section: Introductionmentioning

confidence: 99%

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Hospitalization with varicella and shingles before and after introduction of childhood varicella vaccination in Germany

Siedler

Dettmann

2014

Human Vaccines & Immunotherapeutics

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Hospitalization with varicella and shingles before and after introduction of childhood varicella vaccination in Germany

Siedler

Dettmann

2014

Human Vaccines & Immunotherapeutics

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“…In 2009, a two-dose schedule was endorsed with a second dose at the age of 15–23 months [4]. In the birth cohorts of 2004 to 2009, varicella vaccination coverage increased in 24-month-old children from 43% to 87% for the first dose and from 1% to 64% for the second dose [5]. With the increase in coverage, a significant decrease in varicella cases was observed in a nationwide physician-based sentinel surveillance system: from April 2005 to March 2012, an 85% decline in varicella cases was reported by sentinel physicians.…”

Section: Introductionmentioning

confidence: 99%

Varicella-zoster virus seroprevalence in children and adolescents in the pre-varicella vaccine era, Germany

et al. 2017

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BackgroundIn 2004, universal childhood varicella vaccination was introduced in Germany. We aimed to determine the age-specific prevalence of anti-varicella zoster virus (VZV) IgG-antibodies among children in the pre-varicella vaccine era in Germany, to identify factors associated with VZV seropositivity, and to assess the suitability of a commercially available ELISA for VZV seroepidemiological studies by comparing it with an in-house fluorescent antibody to membrane antigen test (FAMA) as the gold standard.MethodsSerum samples of 13,433 children and adolescents aged 1–17 years included in the population-based German Health Interview and Examination Survey for Children and Adolescents (KiGGS; conducted 2003–2006) were tested for anti-VZV IgG by ELISA. All samples with equivocal ELISA results and a random selection of ELISA-negative and -positive samples were tested by FAMA. Statistical analyses were conducted using a weighting factor adjusting the study population to the total population in Germany. Seroprevalences were calculated as percentages (%) with a 95% confidence interval (CI). Odds ratios (OR) were computed by multivariate logistic regression to determine the association between socio-demographic factors and VZV seropositivity.ResultsThe VZV seropositivity rate was 80.3% (95% CI: 79.3–81.3) in varicella-unvaccinated children and adolescents. VZV seropositivity rates differed significantly between age groups up to age 6 years, but not by gender. Of 118 retested serum samples with an equivocal ELISA result, 45.8% were FAMA-positive. The proportion of samples tested as false-negative in by ELISA varied by age group: 2.6% in children aged 1–6 and 9% in children aged 7–17 years. Multivariate analyses showed that age, having older siblings, and early daycare start were associated with seropositivity in preschoolers; migration background reduced the chance of VZV seropositivity in schoolchildren (OR: 0.65; 0.43–0.99) and adolescents (OR: 0.62; 0.4–0.97).ConclusionIn the pre-varicella vaccine era, most children in Germany contracted varicella by age six. Schoolchildren with a migration background and children without siblings have an increased risk of being VZV seronegative and should be targeted for catch-up vaccination, if they have no history of chickenpox. ELISAs are suitable for use in population-level serosurveys on VZV, but samples with equivocal ELISA results should be retested by FAMA.

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“…Studies analysing surveillance data from the vaccination era showed a decline of varicella incidence and hospitalisations over time and with increasing vaccine uptake (Siedler and Arndt 2010; Siedler et al 2013b; Siedler and Dettmann 2014; Spackova et al 2010; Streng et al 2013). The proportion of patients with complications was higher in the pre-vaccination era (5.7 %) (Wagenpfeil et al 2004) than in the vaccination era (0.34–0.8 %) (Spackova et al 2010; Streng et al 2013).…”

Section: Resultsmentioning

confidence: 99%

Epidemiology and economic burden of measles, mumps, pertussis, and varicella in Germany: a systematic review

Damm

Witte

Wetzka

et al. 2016

Int J Public Health

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ObjectivesDespite the availability of vaccines and the existence of public vaccination recommendations, outbreaks of vaccine-preventable childhood diseases still cause public health debate. The objective of this systematic review was to provide an overview of the current epidemiology and economic burden of measles, mumps, pertussis, and varicella in Germany.MethodsWe systematically reviewed studies published since 2000. The literature search was conducted using PubMed and EMBASE. Also, we used German notification data to give an up-to-date overview of the epidemiology of the four diseases under consideration.ResultsThirty-six studies were included in our review. Results suggest that there is still considerable morbidity due to childhood diseases in Germany. Studies providing cost estimates are scarce. Comparative analyses of different data sources (notification data vs. claims data) revealed a potential underestimation of incidence estimates when using notification data. Furthermore, several studies showed regional differences in incidence of some of the diseases under consideration.ConclusionsOur findings underline the need for improved vaccination and communication strategies targeting all susceptible age and risk groups on a national and local level.Electronic supplementary materialThe online version of this article (doi:10.1007/s00038-016-0842-8) contains supplementary material, which is available to authorized users.

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Die Varizellenimpfung in Deutschland

Cited by 22 publications

References 24 publications

Hospitalization with varicella and shingles before and after introduction of childhood varicella vaccination in Germany

Hospitalization with varicella and shingles before and after introduction of childhood varicella vaccination in Germany

Varicella-zoster virus seroprevalence in children and adolescents in the pre-varicella vaccine era, Germany

Epidemiology and economic burden of measles, mumps, pertussis, and varicella in Germany: a systematic review

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