Die vaskuläre Komponente: Gedanken zur Entstehung des Angiofibroms

Abstract

Incomplete regression of the first branchial arch artery presenting an atavism is suited to explain the vascular tumour component of angiofibromas considering main tumour characteristics (origin in the posterior nasal cavity close to the sphenopalatine foramen, main blood supply from the maxillary artery with possible feeders arising from the internal carotid artery). Our embryological contributions support to define angiofibromas as vascular malformations.

Expression von Proteinen der Cadherin- und Catenin-Proteinfamilie bei juvenilen Angiofibromen

“…Morphologische Beobachtungen weisen auf die Einordnung als Gefäûmissbildung hin [2], die embryologisch durch einen Atavismus der 1. Pharyngealbogenarterie erklärt werden kann [3].…”

Comprehensive review on endonasal endoscopic sinus surgery

“… To perform successful surgery, the specific features of the individual JNA must be considered [ 1044 ], [ 1045 ]. Sense and necessity of preoperative embolization are discussed controversially [ 1044 ].…”

Juvenile Angiofibroma: Evolution of Management

“…More recently, immunohistological and electron microscopic studies have suggested that this lesion may be considered a vascular malformation (or hamartoma) rather than a tumor [10]. These observations led Schick and colleagues [11] to postulate that JA might be due to incomplete regression of the first branchial artery, which arises in embryogenesis between days 22 and 24 and forms a temporary connection between the ventral and dorsal aorta. This artery commonly regresses and forms a vascular plexus that either involutes or may leave remnants, potentially leading to development of JA.…”

“…Gains at chromosomes 4, 6, 8, and X and losses on chromosomes 17, 22, and Y are the most frequent chromosomal abnormalities detected [11, 20–23]. Moreover, Schick [21] described the gene AURKA (20q13.2), a centrosome-associated serine/threonine kinase, with a possible role in chromosomal and genetic instability in JA.…”