Dielectric Study on the Water of Crystallization of Berberine Chloride

Thermal analysis

“…Ac conductivity measurements of a number of Li salt-poly(ethylene oxide) complex polymer electrolytes were correlated with DTA (381). Two types of water of crystallization in the crystalline state of berberine chloride (XIX) were confirmed by dielectric constant measurements and thermal behaviors in the processes of adsorption and desorption isotherms (395). Anhydrous XIX was very hygroscopic, absorbed moisture immediately, and was transformed to a a-hydrate even at low humidity.…”

Process‐Induced Phase Transformation of Berberine Chloride Hydrates

“…BCl is known to exist in anhydrate, dihydrate, and tetrahydrate forms 5–7. The anhydrate form is hygroscopic and unstable under ambient conditions,5 and thus commercial grade BCl is normally a mixture of the dihydrate and tetrahydrate forms.…”

“…The anhydrate form is hygroscopic and unstable under ambient conditions,5 and thus commercial grade BCl is normally a mixture of the dihydrate and tetrahydrate forms. These two hydrates were found to exhibit different powder dissolution behaviors,6, 7 and different disintegration times and dissolution profiles when formulated into a tablet form 6. Based on the specifications in the Chinese Pharmacopoeia 2005, pharmacopoeial grade BCl material should be in the dihydrate form, and the associated weight loss after equilibration for 5 h at 100°C should not exceed 12% (w/w) 8.…”

Phase I study of weekly docetaxel and cisplatin arterial infusion for recurrent head and neck cancer

“…In other words, a granulation matrix with a higher water activity will yield a lower BCl·2H 2 O content after the tray drying process. As BCl·4H 2 O is the thermodynamically stable form at ambient temperature (25°C) and relative humidity (65%),7 the transition from BCl·2H 2 O to BCl·4H 2 O will inevitably occur, but the presence of excipients can retard this transformation process. These observations suggest that excipients can play a critical role in the hydrate transition kinetics of BCl, possibly due to their ability to create different local water activity regions in the granulation matrix.…”