Dielectrophoretically Aligned Carbon Nanotubes to Control Electrical and Mechanical Properties of Hydrogels to Fabricate Contractile Muscle Myofibers

Ramón‐Azcón, Javier; Ahadian, Samad; Estili, Mehdi; Liang, Xiaobin; Ostrovidov, Serge; Kaji, Hirokazu; Shiku, Hitoshi; Ramalingam, Murugan; Nakajima, Ken; Sakka, Yoshio; Khademhosseini, Ali; Matsue, Tomokazu

doi:10.1002/adma.201301300

Cited by 249 publications

(197 citation statements)

References 35 publications

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“…Reproduced with permission. [75] Copyright 2013, Wiley-VCH. c) Preparation process and microscopy images of nanocomposite hydrogels with ordered structures that were based on 2D liquid-crystalline nanosheets.…”

Section: Electric Fieldsmentioning

confidence: 99%

“…[71][72][73][74][75][76] For example, CNTs were connected and aligned as a bundle that was oriented parallel to their axis. [72,75] By adjusting voltages and frequencies, the CNTs were connected and then aligned as the bundle in their axial direction within gelatin methacrylate (GelMA) hydrogels (Figure 4b). Due to their high levels of nanostructure order, these aligned GelMA-CNT hydrogels showed tunable mechanical properties and higher conductivity than that of randomly distributed CNTs in the GelMA hydrogel and pristine GelMA hydrogels.…”

Section: Electric Fieldsmentioning

confidence: 99%

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Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

et al. 2017

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In the human body, many soft tissues with hierarchically ordered composite structures, such as cartilage, skeletal muscle, the corneas, and blood vessels, exhibit highly anisotropic mechanical strength and functionality to adapt to complex environments. In artificial soft materials, hydrogels are analogous to these biological soft tissues due to their “soft and wet” properties, their biocompatibility, and their elastic performance. However, conventional hydrogel materials with unordered homogeneous structures inevitably lack high mechanical properties and anisotropic functional performances; thus, their further application is limited. Inspired by biological soft tissues with well‐ordered structures, researchers have increasingly investigated highly ordered nanocomposite hydrogels as functional biological engineering soft materials with unique mechanical, optical, and biological properties. These hydrogels incorporate long‐range ordered nanocomposite structures within hydrogel network matrixes. Here, the critical design criteria and the state‐of‐the‐art fabrication strategies of nanocomposite hydrogels with highly ordered structures are systemically reviewed. Then, recent progress in applications in the fields of soft actuators, tissue engineering, and sensors is highlighted. The future development and prospective application of highly ordered nanocomposite hydrogels are also discussed.

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Section: Electric Fieldsmentioning

confidence: 99%

Section: Electric Fieldsmentioning

confidence: 99%

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

et al. 2017

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“…When there is no functionalization of either the glass surface or the MWCNT, upon turning off the electric field, the MWCNTs disorganize and spread in the buffer (movie S1 and S3) whereas they stay organized on the biotinylated surface ( Figure 2 showing a wide distribution (40-90 nm). 35 The guiding capacity of the MWCNT tracks has been tested by performing gliding assays.…”

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confidence: 99%

Molecular Motor-Powered Shuttles along Multi-walled Carbon Nanotube Tracks

et al. 2014

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As a complementary tool to nanofluidics, biomolecular-based transport is envisioned for nanotechnological devices. We report a new method for guiding microtubule shuttles on multi-walled carbon nanotube tracks, aligned by dielectrophoresis on a functionalized surface. In the absence of electric field and in fluid flow, alignment is maintained. The directed translocation of kinesin propelled microtubules has been investigated using fluorescence microscopy. To our knowledge, this is the first demonstration of microtubules gliding along carbon nanotubes.

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“…Importantly, encapsulating hydrogels do potentially offer a different level of efficacy in comparison with systemic delivery of cells. Table 1 [52] gelatin methacryloyl (GelMA) hydrogels with carbon nanotubes (CNTs) motife semi-synthetic C2C12 myoblasts CNTs are aligned as bundles within gelatin methacryloyl (GelMA) hydrogels using dielectrophoresis (DEP) tool; anisotropic and electrically conductive hydrogels [53,54] gelatin methacryloyl (GelMA) hydrogels with palladiumbased metallic glass sub-micrometre wires (PdMGSMWs) [75] chitosan/b-glycerolphosphate/collagen (C/GP/Co) natural mouse SCs injectable thermosensitive C/GP/Co hydrogel, forming a porous cobweb-like network implant (undergoes thermal gelation in situ) [76] gelatin-PEG-tyramine (GPT) semi-synthetic human adipose-derived stem cells (h-ADSCs) and basic fibroblast growth factor (bFGF) injectable matrix consists of a gelatin-based in situ cross-linkable hydrogel conjugated with tyramine, using a PEG chain as a hydrophilic linker [77] partially oxidized alginate modified with RGD peptides natural IGF-1 and primary mouse myoblasts a degradable, shape-memory and compressible macroporous alginate scaffold (oxidized alginate modified with RGD peptides is covalently cross-linked using carbodiimide chemistry) [78] partially oxidized alginate modified with RGD peptides natural IGF-1, VEGF, and primary mouse myoblasts a degradable, shape-memory and compressible macroporous alginate scaffold (oxidized alginate modified with RGD peptides is covalently cross-linked using carbodiimide chemistry) [79] rsif.royalsocietypublishing.org J. R. Soc. Interface 15: 20170380 objective of this review is to highlight the most prevalently used hydrogels in the field of bioengineering approaches for muscle regeneration following traumatic injury or in the case of MD treatment.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel biomaterials and their therapeutic potential for muscle injuries and muscular dystrophies

Lev¹,

Seliktar²

2018

J. R. Soc. Interface.

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Muscular diseases such as muscular dystrophies and muscle injuries constitute a large group of ailments that manifest as muscle weakness, atrophy or fibrosis. Although cell therapy is a promising treatment option, the delivery and retention of cells in the muscle is difficult and prevents sustained regeneration needed for adequate functional improvements. Various types of biomaterials with different physical and chemical properties have been developed to improve the delivery of cells and/or growth factors for treating muscle injuries. Hydrogels are a family of materials with distinct advantages for use as cell delivery systems in muscle injuries and ailments, including their mild processing conditions, their similarities to natural tissue extracellular matrix, and their ability to be delivered with less invasive approaches. Moreover, hydrogels can be made to completely degrade in the body, leaving behind their biological payload in a process that can enhance the therapeutic process. For these reasons, hydrogels have shown great potential as cell delivery matrices. This paper reviews a few of the hydrogel systems currently being applied together with cell therapy and/or growth factor delivery to promote the therapeutic repair of muscle injuries and muscle wasting diseases such as muscular dystrophies.

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Dielectrophoretically Aligned Carbon Nanotubes to Control Electrical and Mechanical Properties of Hydrogels to Fabricate Contractile Muscle Myofibers

Cited by 249 publications

References 35 publications

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

Molecular Motor-Powered Shuttles along Multi-walled Carbon Nanotube Tracks

Hydrogel biomaterials and their therapeutic potential for muscle injuries and muscular dystrophies

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