Diesel Exhaust Is Not a Pulmonary Carcinogen in CD-1 Mice Exposed under Conditions Carcinogenic to F344 Rats

Mauderly, Joe L.; Banas, Deborah A.; Griffith, William C.; Hahn, Fletcher F.; Henderson, Rogene F.; McClellan, R.O.

doi:10.1093/toxsci/30.2.233

Cited by 14 publications

(16 citation statements)

References 20 publications

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“…to particle-induced lung injury, [13][14][15] we first characterized cell proliferation, inflammation, and fibrosis in a subchronic inhalation model using C57Bl/6 mice. This strain of mice exhibits transient increases in BrdU labeling at alveolar duct bifurcations and terminal bronchioles, as well as focal bronchiolar thickening after brief 5-hour exposures to chrysotile asbestos.…”

Section: Discussionmentioning

confidence: 99%

Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice

Robledo

Buder-Hoffmann

Cummins

et al. 2000

The American Journal of Pathology

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Activation of extracellular signal-regulated kinases (ERK) has been associated with the advent of asbestos-associated apoptosis and proliferation in me-3 Proliferation within pulmonary interstitial cells, increases in lung hydroxyproline content, a biomarker of collagen synthesis, and morphological evidence of pulmonary fibrosis become apparent with prolonged high-dose exposure (Ն14 days) to crocidolite asbestos.

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Section: Discussionmentioning

confidence: 99%

Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice

Robledo

Buder-Hoffmann

Cummins

et al. 2000

The American Journal of Pathology

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“…Interestingly, some of these compounds induce skin irritation or sensitization (e.g., dimethylbenz[a]anthracene, 4,4´-methylenedianiline, and TCDD). Relevant to this relationship are the associations of DEPs with augmented sensitization and airway responsiveness (32,34-40) and possibly lung tumors, noted only in rats (322)(323)(324)(325)(326)(327)(328)(329)(330)(331)(332). In addition, toluene diamine is a metabolite of toluene diisocyanate (307), a potent asthmagen, and thereby links, in principal, reactive intermediates of carcinogens with asthma.…”

Section: Evaluating Human Exposure and Its Relationship To Asthmamentioning

confidence: 99%

Hazardous air pollutants and asthma.

Leikauf

2002

Environ Health Perspect

190

131

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“…The null result in two strains of rats at low exposure, plus the null results in longterm bioassays of DEP-exposed mice (46) and DEP-exposed hamsters (33,36) …”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of rat lung tumors from lifetime inhalation of diesel exhaust.

Valberg

Crouch

1999

Environ Health Perspect

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Estimating the carcinogenic potential of exposure to diesel-engine ehaust particulates (DEPs) is problematic. In rats, high concentrations of DEPs (> 1,000 pg/m3) inhaled over a lifetime result in excess lung tumors. However, data for rats exposed to DEP at concentrtion not associated with lung overload are consistent with no tumorigenic effect Individual rat studies have only a limited number of exposure groups; therefore, we combined the tumor data from eight chronic inhalation studies in a meta-analysis. (16)]. Therefore, the lung tumor response in heavily exposed laboratory rats is not believed to be relevant to humans (8,(17)(18)(19)(20)(21)(22), and the high-dose rats are not a reliable basis for DEP quantitative risk assessment.

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Diesel Exhaust Is Not a Pulmonary Carcinogen in CD-1 Mice Exposed under Conditions Carcinogenic to F344 Rats

Cited by 14 publications

References 20 publications

Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice

Increased Phosphorylated Extracellular Signal-Regulated Kinase Immunoreactivity Associated with Proliferative and Morphologic Lung Alterations after Chrysotile Asbestos Inhalation in Mice

Hazardous air pollutants and asthma.

Meta-analysis of rat lung tumors from lifetime inhalation of diesel exhaust.

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