Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Frontela‐Saseta, Carmen; González-Bermúdez, Carlos A.; García‐Marcos, Luis

doi:10.3390/jcm9072063

Cited by 13 publications

(13 citation statements)

References 103 publications

(123 reference statements)

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“…For instance, alterations in the gut microbiota caused by a Western high-fat diet have recently been recognized as a major contributing factor to the colorectal cancer epidemic ( 32 ) . High -sucrose- high - fat dietary patterns were supposed to participate in the asthma pathogenesis through intestinal bacteria ( 33 , 34 ). Currently, there is not related research on whether dietary factors are involved in the pathology of MG.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota as Regulators of Th17/Treg Balance in Patients With Myasthenia Gravis

Chen

Tang

2021

Front. Immunol.

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Myasthenia gravis (MG) is an acquired neurological autoimmune disorder characterized by dysfunctional transmission at the neuromuscular junction, with its etiology associated with genetic and environmental factors. Anti-inflammatory regulatory T cells (Tregs) and pro-inflammatory T helper 17 (Th17) cells functionally antagonize each other, and the immune imbalance between them contributes to the pathogenesis of MG. Among the numerous factors influencing the balance of Th17/Treg cells, the gut microbiota have received attention from scholars. Gut microbial dysbiosis and altered microbial metabolites have been seen in patients with MG. Therefore, correcting Th17/Treg imbalances may be a novel therapeutic approach to MG by modifying the gut microbiota. In this review, we initially review the association between Treg/Th17 and the occurrence of MG and subsequently focus on recent findings on alterations of gut microbiota and microbial metabolites in patients with MG. We also explore the effects of gut microbiota on Th17/Treg balance in patients with MG, which may provide a new direction for the prevention and treatment of this disease.

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Section: Introductionmentioning

confidence: 99%

Gut Microbiota as Regulators of Th17/Treg Balance in Patients With Myasthenia Gravis

Chen

Tang

2021

Front. Immunol.

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“…Several meta-analyses have suggested that fruit and vegetable consumption may reduce the risk of asthma due to their antioxidant effects 27 28. There are also some studies suggesting that the Mediterranean diet that is rich in vegetables and fruits, correlated negatively with the risk of asthma compared with the Western diet 6 7. As vegetables and fruits are the main sources of carotenoids, these studies indirectly suggested that carotenoid intakes reduce asthma risk.…”

Section: Discussionmentioning

confidence: 99%

“…Increasing evidence showed that oxidative stress is involved in the pathophysiological mechanism of asthma and implicated in the inflammation and severity of asthma 3–5. Dietary epidemiological evidence suggests that Western diets, characterised by high intake of saturated fats and simple sugars, are related to an increased incidence of asthma 6 7. While Mediterranean diets, characterised by an intake of plant-based foods (mainly vegetables and fruits), may reduce the risk of asthma through its antioxidant and anti-inflammatory effects 8…”

Section: Introductionmentioning

confidence: 99%

Association between dietary carotenoid intakes and the risk of asthma in adults: a cross-sectional study of NHANES, 2007–2012

Zhang

2022

BMJ Open

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ObjectiveTo investigate the association between dietary carotenoid intake and asthma using data from a nationally representative sample of US adults.DesignCross-section study.SettingThe National Health and Nutrition Examination Survey 2007–2012.ParticipantsA total of 13 039 participants aged 20–80 years (current asthma n=1784, non-current asthma n=11 255) were included in this study.Primary and secondary outcome measuresAsthma was defined by self-report questionnaires. Weighted logistic regression analyses and the smooth curve fittings were performed to explore the association between total carotenoid intake, dietary carotenoid subgenera, including (α-carotene, β-carotene, β-cryptoxanthin, lutein with zeaxanthin and lycopene) and the risk of asthma.ResultsThe ORs with 95% CIs of dietary α-carotene, dietary β-carotene, dietary β-cryptoxanthin, total lutein with zeaxanthin, total lycopene, dietary carotenoid and total carotenoid intake for individuals with current asthma after adjusting the confounders in model 3 were 0.80 (0.67 to 0.95), 0.67 (0.57 to 0.79), 0.68 (0.55 to 0.85), 0.77 (0.61 to 0.98), 0.71 (0.57 to 0.87), 0.75 (0.59 to 0.96) and 0.61 (0.48 to 0.76) in the highest versus lowest quartile, respectively. The smooth curve fittings suggested a non-linear relationship between total carotenoid intake and the risk of current asthma.ConclusionsHigher intake of a-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein with zeaxanthin and total carotenoid were associated with lower odds of having current asthma in the US adults. This is a cross-sectional study and no causal relationship can be drawn, so caution is needed to interpret the results.

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“…In homeostatic conditions, the healthy gut microbiota can efficiently prevent pathogen infection, reducing the chance of developing inflammation 17 . On the contrary, early life gut dysbacteriosis may lead to altered immune response and chronic inflammatory respiratory disorders, especially childhood asthma 18 . Therefore, people are gradually paying attention to the role of gut microbiota and gut‐lung axis in asthma, as well as the mechanism of gut microbiota affecting homeostasis and susceptibility to asthma 19 .…”

Section: Introductionmentioning

confidence: 99%

Gut‐lung axis and asthma: A historical review on mechanism and future perspective

Song,

Liang,

Lin

et al. 2024

Clinical & Translational All

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BackgroundGut microbiota are closely related to the development and regulation of the host immune system by regulating the maturation of immune cells and the resistance to pathogens, which affects the host immunity. Early use of antibiotics disrupts the homeostasis of gut microbiota and increases the risk of asthma. Gut microbiota actively interact with the host immune system via the gut‐lung axis, a bidirectional communication pathway between the gut and lung. The manipulation of gut microbiota through probiotics, helminth therapy, and fecal microbiota transplantation (FMT) to combat asthma has become a hot research topic.BodyThis review mainly describes the current immune pathogenesis of asthma, gut microbiota and the role of the gut‐lung axis in asthma. Moreover, the potential of manipulating the gut microbiota and its metabolites as a treatment strategy for asthma has been discussed.ConclusionThe gut‐lung axis has a bidirectional effect on asthma. Gut microecology imbalance contributes to asthma through bacterial structural components and metabolites. Asthma, in turn, can also cause intestinal damage through inflammation throughout the body. The manipulation of gut microbiota through probiotics, helminth therapy, and FMT can inform the treatment strategies for asthma by regulating the maturation of immune cells and the resistance to pathogens.

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Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Cited by 13 publications

References 103 publications

Gut Microbiota as Regulators of Th17/Treg Balance in Patients With Myasthenia Gravis

Gut Microbiota as Regulators of Th17/Treg Balance in Patients With Myasthenia Gravis

Association between dietary carotenoid intakes and the risk of asthma in adults: a cross-sectional study of NHANES, 2007–2012

Gut‐lung axis and asthma: A historical review on mechanism and future perspective

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