Diet and Cancer Risk in the Korean Population: A Meta-analysis

Woo, Hae Dong; Park, Sohee; Oh, Kyungwon; Kim, Hyun Ja; Shin, Hae Rim; Moon, Hyun Kyung; Kim, Jeongseon

doi:10.7314/apjcp.2014.15.19.8509

Cited by 92 publications

(89 citation statements)

References 38 publications

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“…Some large cohort studies in Korea have shown that people who prefer salty food have a higher risk for gastric cancer [27]. Intake of salted foods has been demonstrated to enhance the risk of H. pylori infection and, even worse, to increase the capability of H. pylori to promote gastric cancer development by enhancing cagA expression [28].…”

Section: Risk Factors For Gastric Cancermentioning

confidence: 99%

Etiology and Prevention of Gastric Cancer

Cheng

Lin

2016

Gastrointest Tumors

130

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Background: Gastric cancer is a heterogeneous malignant disease associated with environmental and genetic predisposing factors. While gastric cancer incidence and mortality fell greatly globally over the past decades, it remains the fourth cause of cancer-related death worldwide. Thus, prevention of gastric cancer is still a major strategy for improvement of gastric cancer prognosis. Summary:Helicobacter pylori infection has been demonstrated to be a major risk factor for the development of gastric cancer. Unhealthy diet and lifestyle, including high-salt food, smoking and drinking, are able to induce genotypic and phenotypic transformation of gastric epithelial cells. Gene mutations (such as E-cadherin) in stomach epithelial cells are major genetic causes for gastric cancer. The eradication of H. pylori has been demonstrated to be an effective approach for primary prevention of gastric cancer. Increased intake of a diet rich in vegetables and fresh fruits as well as smoking cessation have been shown to reduce the incidence of gastric cancer. The secondary prevention strategy is to screen premalignant gastric lesions by endoscopy. Biomarker tests are also reliable methods to identify gastric precancerous lesions. Endoscopy screening is still the gold standard for diagnosis of gastric cancer. Key Message:H. pylori infection, a diet rich in salted and/or smoked food and red meat, as well as gene mutations are major risk factors for the development of gastric cancer. Practical Implications: The eradication of H. pylori is a major primary preventive strategy of gastric cancer. A healthy lifestyle, including increased intake of a diet rich in fruit and vegetables, reduced intake of salted and smoked food and red meat, a reduction of alcohol intake as well as smoking cessation will be effective approaches for the prevention of gastric cancer.

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Section: Risk Factors For Gastric Cancermentioning

confidence: 99%

Etiology and Prevention of Gastric Cancer

Cheng

Lin

2016

Gastrointest Tumors

130

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“…Prevention:Getting rid of H.pylori in those who are infected decreases the risk of gastric cancer,at least in those who are Asian [83].A 2014 meta-analysis of observational studies found that a diet high in fruits, mushrooms, garlic, soybeans, and green onions was associated with a lower risk of stomach cancer in Korean population [84].Low doses of vitamins, especially from a healthy diet, decreases the risk of stomach cancer [85].A previous review of antioxidant supplementation did not find supporting evidence and possibly worse outcomes [86].…”

Section: Prognosis and Preventionmentioning

confidence: 99%

Gastric Cancer:Risk Factors, Diagnosis and Management

Mustafa¹,

Menon²,

Muniandy³

et al. 2017

IOSR JDMS

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“…Garlic has been used to treat many disease conditions which include, cardiac diseases, diabetes, osteoarthritis, hay fever (allergic rhinitis), cold and flu, cough, headache, stomach ache, gout, rheumatism, haemorrhoids, asthma, bronchitis and warts [4][5][6]. It is equally used to treat athlete's foot [7], prostate cancer and bladder cancer, [8] and globally recognized as a potent wound healing agent [9]. Some biological studies have demonstrated that garlic has potential antioxidant, hypoglycaemic, hypotensive, hypothrombotic [10], nephroprotective and hepatoprotective properties [11].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2018

RJLBPCS

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ABSTRACT:Garlic is a widely consumed medicinal plant and most of its biological effects have been established. But its effect on reproductive function and fertility in males is not conclusively studied. This study was conducted to investigate the influence of aqueous extract of garlic bulb on sperm characteristics and serum reproductive hormone concentrations in Wistar albino rats. Animals were grouped randomly (n=5/group) and gavaged with garlic extract (0, 50, 100, 200 or 300 mg/kg/day) for 28 days. Some other groups received garlic extract 24 h after they were injected alloxan (100 mg/kg, ip). Animals were sacrificed and serum levels of FSH, LH and testosterone were analysed as well as sperm collected from the epididymis. Sperm morphology, FSH and LH were not affected in all rats that received only garlic extract compared to control. In addition, sperm motility, sperm count and testosterone were reduced (P < 0.05) in rats that received 300 mg/kg extract, but the lower dose treatments failed to produce any significant effect. In alloxan+extract administered rats, sperm motility and count were reduced dose-dependently, but effect on sperm count was significant only in rats that received 200 and 300 mg/kg of extract. Furthermore, testosterone level was decreased, while the other hormones were unaltered. The results suggest that garlic alters sperm characteristics and decreases testosterone concentration in rats when chronically consumed at high doses.

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Diet and Cancer Risk in the Korean Population: A Meta-analysis

Cited by 92 publications

References 38 publications

Etiology and Prevention of Gastric Cancer

Etiology and Prevention of Gastric Cancer

Gastric Cancer:Risk Factors, Diagnosis and Management

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