Diet and colorectal cancer

Ruiz, Raúl Baena; Salinas, Pedro

doi:10.1016/j.maturitas.2014.12.017

Cited by 188 publications

(150 citation statements)

References 45 publications

(62 reference statements)

Supporting

Mentioning

142

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, new projections allow predicting that by 2020, there will be 15 million new cases of cancer every year [1,2] . Nowadays, the third most common cancer worldwide is the colorectal cancer and this is also the fourth most common cause of death [3][4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

et al. 2016

View full text Add to dashboard Cite

SbstractOxaliplatin was inserted into polymeric matrices aiming to study the interaction of this drug with these polymers and its capability to diffuse to the environment. Tested polymers were: (1) polyethylene glycol (PEG), (2) poly(lactic-co-glycolic acid) (PLGA), and (3) a copolymer of them (PLGA-PEG). The latter two were synthesized by us using polycondensation in bulk. Oxaliplatin was included in the matrices by the melt mixing process followed by casting. Fourier tran sform infrared spectroscopy (FTIR), proton nuclear magnetic resonance ( 1 H-NMR) and X-ray diffraction (DRX) studies of the polymers were performed proving the obtaining of the desired materials. In addition, the interaction between drug and matrices and the release profile of the oxaliplatin from these matrices were analyzed. Among them, PEG did not control the oxaliplatin release. In turn, PLGA and PLGA-PEG present drug release profiles quite similar. Oxaliplatin was completely released from PLGA and PLGA-PEG in 5 hours, by a relaxation mechanism. There was no evidence of oxaliplatin interaction with the different polymers. In addition, as the PEG improves the biocompatibility and biomasking, obtained results prove the obtaining of a drug release system, which allowed the total use of the drug improving the cancer treatment and even the welfare of the patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Their benefits can be observed in inhibitory action at early tumour stages or at advanced or metastatic tumour stages 34 .…”

Section: Crc and Fibre Fruit And Vegetablesmentioning

confidence: 99%

Rising rates of colorectal cancer among younger Iranians: is diet to blame?

Arani¹,

Kerachian²

2017

Curr. Oncol.

View full text Add to dashboard Cite

show abstract

“…Evidence suggests that diet represents 30-35% of all risk factors contributing to the onset of cancer. Positive health effects have been reported for vegetables, fruits, and whole grains [1][2][3][4][5][6]. Whole grain foods, rich in dietary fiber, minerals, vitamins, and phytochemicals, are recognized as agents exerting health protective effects [7].…”

Section: Introductionmentioning

confidence: 99%

Dietary alkylresorcinols and cancer prevention: a systematic review

Kruk

Aboul‐Enein

Bernstein

et al. 2017

Eur Food Res Technol

View full text Add to dashboard Cite

nervous system, adenocarcinoma, hepatocarcinoma, cervix squamous carcinoma, and ovarian cancer cell lines, at micromolar alkylresorcinols concentration. Evidence from prospective studies confirmed significant inverse associations between whole grains intake and distal colon cancer risk. Model studies suggest a high cytotoxicity of alkylresorcinols toward cancer cells. These findings maintain that alkylresorcinols as components of whole grains are likely to find application in cancer prevention; however, the need for intervention studies to confirm their preventive action is warranted. Abstract The potential role of alkylresorcinol compound from whole grains for prevention and inhibition of human cancer cell lines has been reported in observational and in vitro studies. The objective of this study was to present an updated review on the association between alkylresorcinols and cancer risk and aspects of their bioactivity with implications for carcinogenesis. Relevant studies were identified by searching PubMed, Scopus, ProQuest, EBSCOhost, SpringerLink, ArticleFirst, Taylor & Francis, Wiley Online, and ScienceDirect electronic databases using these search terms and key words: alkylresorcinols, cancer, carcinoma, risk. Furthermore, references from retrieved articles were also reviewed. Four observational and 10 in vitro studies were included in the analysis of natural or synthetic alkylresorcinols for anticancer activities. Two prospective studies reported a 52-66% risk reduction of distal colon cancer at nanomolar alkylresorcinols concentration in plasma; the remaining studies found no reduction of endometrial cancer risk and an approximate 40% increase in prostate cancer risk. In vitro studies presented inhibition of human colon, breast, lung, central Keywords

show abstract

Diet and colorectal cancer

Cited by 188 publications

References 45 publications

Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

Rising rates of colorectal cancer among younger Iranians: is diet to blame?

Dietary alkylresorcinols and cancer prevention: a systematic review

Contact Info

Product

Resources

About