Diet and  Helicobacter pylori  infection

Hołubiuk, Łukasz; Imiela, Jacek

doi:10.5114/pg.2016.61487

Cited by 19 publications

(20 citation statements)

References 29 publications

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“…In univariate analysis H. pylori was associated with several habits related to increased salt intake (adding extra salt to food and the consumption of pickled and meat products), but not in multivariate analysis after including a large number of factors. High salt intake has been shown not only to facilitate the colonization of the gastric mucosa by H. pylori but also increase inflammation and accelerate carcinogenesis [17,31]. Beevers et al [32] reported a correlation between urinary sodium excretion and H. pylori infection rates in 2004 in the EUROGAST and INTERSALT study population from ten countries [32] In our study the association between H. pylori and lower fruit and vegetable intake remained strong in multivariate analysis.…”

Section: Discussionsupporting

confidence: 57%

Sociodemographic, Lifestyle and Medical Factors Associated with Helicobacter Pylori Infection

Ražuka-Ebela

Poļaka

Parshutin

et al. 2020

JGLD

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Background and Aims: The prevalence of Helicobacter pylori (H. pylori) infection is higher in developing countries and is often linked to lower socioeconomic status. Few studies have investigated the association between H. pylori and individual level characteristics in Europe, where several countries have a high prevalence of H. pylori infection. The study aimed to identify risk factors for H. pylori infection among adults in a large clinical trial in Latvia. Methods: 1,855 participants (40-64 years) of the “Multicenter randomized study of H. pylori eradication and pepsinogen testing for prevention of gastric cancer mortality” (GISTAR study) in Latvia tested for H. pylori IgG antibodies were included in a cross-sectional analysis. Sociodemographic, lifestyle and medical factors were compared for participants seropositive (H. pylori+) and seronegative. Mutually adjusted odds ratios (OR) were calculated for H. pylori+ and factors significant in univariate analysis (education, smoking, binge drinking, several dietary habits, history of H. pylori eradication and disease), adjusting for age, gender and income. Results: Of the participants 1,044 (55.4%) were H. pylori seropositive. The infection was associated with current (OR: 1.34, 95%CI: 1.01-1.78) and former (OR: 1.38; 95%CI: 1.03-1.85) smoking, binge drinking (OR: 1.35; 95%CI: 1.03-1.78), having ≥200g dairy daily (OR: 1.37; 95%CI: 1.11-1.69), and very hot food/drinks (OR: 1.32; 95%CI: 1.03-1.69) and inversely with ≥400g vegetables/fruit daily (OR: 0.76; 95%CI: 0.60-0.96), history of H. pylori eradication (OR: 0.57; 95%CI: 0.39-0.84), peptic ulcer (OR: 0.55; 95%CI: 0.38-0.80) and cardiovascular disease (OR: 0.78; 95%CI: 0.61-0.99). Conclusions: After mutual adjustment, H. pylori seropositivity was associated with lifestyle and in particular dietary factors rather than socioeconomic indicators in contrast to the majority of other studies.

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Section: Discussionsupporting

confidence: 57%

Sociodemographic, Lifestyle and Medical Factors Associated with Helicobacter Pylori Infection

Ražuka-Ebela

Poļaka

Parshutin

et al. 2020

JGLD

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“…More randomized controlled trials should be conducted to explore further the effect of different food components on H. pylori eradication. Such research would identify healthier alternatives for treating H. pylori colonization than pharmacological therapy that has side effects and leads to antibiotic resistance [ 51 ]. On the other hand, Xia et al argue that it is important to study dietary patterns and not food items in isolation, since nutrients do not only act independently but may also interact together [52] since H. pylori was positively association with a diet rich in carbohydrates and sweets, and negatively associated with a diet high in protein and cholesterol, while no association was found between H. pylori and any food items or groups studied in isolation in their cross sectional study.…”

Section: Discussionmentioning

confidence: 99%

Dietary habits and Helicobacter pylori infection: a cross sectional study at a Lebanese hospital

Assaad

Chaaban²,

Tannous

et al. 2018

BMC Gastroenterol

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BackgroundTo examine the association between dietary habits and Helicobacter pylori (H. pylori) infection among patients at a tertiary healthcare center in Lebanon.MethodsThis cross-sectional study was conducted on 294 patients in 2016, at a hospital in Northern Lebanon. Participants were interviewed using a structured questionnaire to collect information on socio-demographic and lifestyle characteristics; dietary habits were ascertained via a short food frequency questionnaire (FFQ). H. pylori status (positive vs. negative) was determined after upper GI endoscopy where gastric biopsy specimens from the antrum, body, and fundus region were collected and then sent for pathology analysis. Multivariable logistic regression was conducted to identify the association between socio-demographic, lifestyle, dietary and other health-related variables with H pylori infection.ResultsThe prevalence of H. pylori infection was found to be 52.4% in this sample. Results of the multivariable analysis showed that H. pylori infection risk was higher among participants with a university education or above (OR = 2.74; CI = 1.17–6.44), those with a history of peptic ulcers (OR = 3.80; CI = 1.80–8.01), gastric adenocarcinoma (OR = 3.99; CI = 1.35–11.83) and vitamin D level below normal (OR = 29.14; CI = 11.77–72.13). In contrast, hyperglycemia was protective against H. pylori (OR = 0.18; CI = 0.03–0.89). No relationship between dietary habits and H. pylori infection was found in the adjusted analysis.ConclusionsSocio-demographic and clinical variables are found to be associated with H. pylori, but not with dietary factors. Further studies are needed to investigate the effect of diet on H. pylori risk.

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“…Documented data revealed that 20% to 90% of hospitalized patients with gastrointestinal disorders were infected with H. pylori strains (5,6). In keeping with this, there were no previously recorded data regarding the main sources and also route of transmission of H. pylori into human (7). Several previously published data revealed that H. pylori had a significant prevalence in various types of foods, especially milk, meat, salad, vegetables, and ready to eat foods, which may show the food-borne route of this bacterium (8)(9)(10).…”

Section: Introductionmentioning

confidence: 90%

Prevalence and Genotyping of Helicobacter pylori Isolated From Meat, Milk and Vegetable in Iran

Talimkhani

Mashak

2017

Jundishapur J Microbiol

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Background: Despite the considerable clinical role of Helicobacter pylori, its certain routes of transmission and origin have not been reported. Based on the argumentative hypothesis, foods play an imperative role in the spread of H. pylori to humans. Objectives: The current research was done to investigate the prevalence rate and distribution of Vacuolating Cytotoxin A and Cytotoxin Associated Gene A genotypes in the H. pylori strains isolated from meat, milk, and vegetables. Methods: A total of 340 food samples were collected and directly moved to the laboratory. Samples were cultured and H. pylori colonies were approved using the gram staining, urease test, and 16s rRNA-based polymerase chain reaction (PCR) amplification. Positive strains were tested for distribution of vacA and cagA genotypes using the multiplex-PCR. Results: Out of 340 samples, 40 (11.76%) harbored H. pylori. Prevalence of H. pylori in meat, milk, and vegetable samples were 7.33%, 16%, and 12.50%, respectively. Ovine milk (26%) was the most commonly contaminated sample. The most commonly detected genotypes were vacA s1a (87.50%), vacA m1a (87.50%), vacA s2 (82.50%), cagA (80%), and vacA m2 (62.50%). Genotypes of S1am1a (62.50%), s2m1a (55%), s1am2 (50%), s2m2 (45%), and m1am2 (42.50%) were the most commonly detected combined genotypes. Conclusions: Milk, vegetables, and meat, are latent sources of H. pylori. Similarity in the genotyping pattern of H. pylori strains of various samples represents their similar sources of infection. Further studies are required for finding the exact sources of H. pylori strains.

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Diet and Helicobacter pylori infection

Cited by 19 publications

References 29 publications

Sociodemographic, Lifestyle and Medical Factors Associated with Helicobacter Pylori Infection

Sociodemographic, Lifestyle and Medical Factors Associated with Helicobacter Pylori Infection

Dietary habits and Helicobacter pylori infection: a cross sectional study at a Lebanese hospital

Prevalence and Genotyping of Helicobacter pylori Isolated From Meat, Milk and Vegetable in Iran

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