Diet and liver cancer risk: a narrative review of epidemiological evidence

Yang, Wanshui; Zeng, Xufen; Liu, Zhining; Zhao, Qihong; Tan, Yuting; Gao, Jing; Li, Honglan; Xiang, Yong‐Bing

doi:10.1017/s0007114520001208

Cited by 117 publications

(88 citation statements)

References 162 publications

(252 reference statements)

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“…In the cohorts of EPIC and NHS-HPFS, the main food sources of MUFA was from olive oil and nuts (~20%) 14,24 ; whereas in the NIH-AAPR study, it was meat and meat products (>20%) 12 ; and dietary fat from the plant might be associated with a decreased risk of HCC. 11,14,24 Sex hormones might be another critical factor. Our study was a population-based cohort of Chinese male adults.…”

Section: Discussionmentioning

confidence: 99%

“…One of the main reasons that was necessary but not sufficient to address was a diet pattern. In the cohorts of EPIC and NHS‐HPFS, the main food sources of MUFA was from olive oil and nuts (~20%) 14,24 ; whereas in the NIH‐AAPR study, it was meat and meat products (>20%) 12 ; and dietary fat from the plant might be associated with a decreased risk of HCC 11,14,24 . Sex hormones might be another critical factor.…”

Section: Discussionmentioning

confidence: 99%

“…However, the associations between specific nutrients and cancer risks, especially between fat and liver cancer, have not been fully illustrated. As reviewed recently, the existing epidemiological evidence is limited and inconclusive 11 . The prospective American Association of Retired Persons (AARP) Diet and Health study conducted at the National Institute of Health (NIH) showed statistically positive associations between HCC and dietary fat.…”

Section: Introductionmentioning

confidence: 99%

“…As reviewed recently, the existing epidemiological evidence is limited and inconclusive. 11 The prospective American Association of Retired Persons (AARP) Diet and Health study conducted at the National Institute of Health (NIH) showed statistically positive associations between HCC and dietary fat. Specifically, for a 5% increase in the proportion of energy from each fat subtype, the hazard ratio (HR) was 1.10 for total fat, 1.38 for saturated fat, and 1.18 for monounsaturated fat (MUFA) with null significance.…”

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confidence: 99%

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Dietary fat intake and liver cancer incidence: A population‐based cohort study in Chinese men

Wang

Shen

et al. 2021

Intl Journal of Cancer

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To date, limited studies have focused on the association between dietary fat and liver cancer risk, especially in China. Our study aims to evaluate the association between dietary fat intake and liver cancer incidence risk in men. Dietary fat intake was obtained through a validated food frequency questionnaire in a Chinese prospective cohort. The Cox regression model was utilized to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). After exclusion, 59 998 recruitments were finally analyzed with a total follow-up time of 714 339 person-years, 431 incident liver cancer cases were newly identified among them. The adjusted HRs (95% CIs) for the highest vs lowest quartile of total fat, saturated fat, monounsaturated fat (MUFA), and poly-

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Dietary fat intake and liver cancer incidence: A population‐based cohort study in Chinese men

Wang

Shen

et al. 2021

Intl Journal of Cancer

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“…Liver cancer remains the fifth most common malignant tumor in men and the seventh most common among women, worldwide, and is the third leading cause of cancer-associated mortality, exceeded only by stomach and lung cancer [ 2 , 3 ]. The most common risk factors for liver cancer are chronic hepatitis B and C infection, long-term alcohol abuse, dietary exposure to aflatoxin B1, smoking and several metabolic diseases [ 4 ]. Liver cancer has an extremely high recurrence rate with poor prognoses, mainly due to active angiogenesis, a high propensity to metastasize and the rapid proliferation of tumor cells [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis

et al. 2020

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Background Fatty acid synthase (FASN) is highly expressed in various types of cancer and has an important role in carcinogenesis and metastasis. To clarify the mechanisms of FASN in liver cancer invasion and metastasis, the FASN protein interaction network in liver cancer was identified by targeted proteomic analysis. Methods Wound healing and Transwell assays was performed to observe the effect of FASN during migration and invasion in liver cancer. Isobaric tags for relative and absolute quantitation (iTRAQ)-based mass spectrometry were used to identify proteins interacting with FASN in HepG2 cells. Differential expressed proteins were validated by co-immunoprecipitation, western blot analyses and confocal microscopy. Western blot and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were performed to demonstrate the mechanism of FASN regulating metastasis. Results FASN knockdown inhibited migration and invasion of HepG2 and SMMC7721 cells. A total of, 79 proteins interacting with FASN were identified. Additionally, gene ontology term enrichment analysis indicated that the majority of biological regulation and cellular processes that the FASN-interacting proteins were associated with. Co-precipitation and co-localization of FASN with fascin actin-bundling protein 1 (FSCN1), signal-induced proliferation-associated 1 (SIPA1), spectrin β, non-erythrocytic 1 (SPTBN1) and CD59 were evaluated. Knockdown of FASN in liver cancer reduced the expression of FSCN1, SIPA1, SPTBN1 and CD59. Furthermore, inhibition of FASN, FSCN1 or SPTBN1 expression in liver cancer resulted in alterations of epithelial–mesenchymal transition (EMT)-associated markers E-cadherin, N-cadherin, vimentin and transcription factors, Snail and Twist, at the mRNA level, and changes in matrix metallopeptidase (MMP)-2 and MMP-9 protein expression. Conclusion The results suggested that the FASN-interacting protein network produced by iTRAQ-based proteomic analyses may be involved in regulating invasion and metastasis in liver cancer by influencing EMT and the function of MMPs.

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Cumulative consumption of tea is associated with lower risk of liver cancer: Updated results from the Shanghai Women's Health Study

Tan

Liu

et al. 2022

Intl Journal of Cancer

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Prospective epidemiological studies have provided limited evidence for an association between tea consumption and liver cancer risk. Based on a population-based prospective cohort study in middle-aged Chinese women, we investigated the association between tea consumption and the risk of primary liver cancer. Detailed information on tea drinking habits and other potential confounders was obtained at the baseline interview. Incident liver cancer cases were identified through record linkage with the population-based cancer registry and verified through home visits and review of medical charts by medical experts. Multiple aspects of tea drinking habits including starting age, duration, intensity and cumulative consumption of any type of tea and green tea were considered.Multivariable-adjusted hazard ratios (aHRs) and their 95% confidence intervals (CIs) were derived from the Cox regression models. After a median follow-up time of 18.12 (interquartile range = 1.59) years, 253 incident liver cancer cases were identified from 71 841 cohort members. Compared with never tea drinkers, the risk of liver cancer for participants who have consumed over 30 kg of dried tea leaves cumulatively was 0.56 (95% CI: 0.32-0.97). For those who drank green tea only, the aHR was 0.54 (95% CI: 0.30-0.98). This updated study suggested an inverse association between cumulative consumption of tea, especially green tea and the risk of primary liver cancer.

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Diet and liver cancer risk: a narrative review of epidemiological evidence

Cited by 117 publications

References 162 publications

Dietary fat intake and liver cancer incidence: A population‐based cohort study in Chinese men

Dietary fat intake and liver cancer incidence: A population‐based cohort study in Chinese men

Identification of the fatty acid synthase interaction network via iTRAQ-based proteomics indicates the potential molecular mechanisms of liver cancer metastasis

Cumulative consumption of tea is associated with lower risk of liver cancer: Updated results from the Shanghai Women's Health Study

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