2022
DOI: 10.3390/nu14091764
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Diet and Risk of Gastric Cancer: An Umbrella Review

Abstract: Several dietary exposures have been associated with gastric cancer (GC), but the associations are often heterogenous and may be afflicted by inherent biases. In the context of an Umbrella Review (UR), we provide an overview and a critical evaluation of the strength and quality, and evidence classification of the associations of diet-related exposures in relation to the risk of GC. We searched PubMed and Scopus for eligible meta-analyses of observational studies published in English from inception to 12 Decembe… Show more

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Cited by 40 publications
(24 citation statements)
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“…For example, a 5 g/day increase in salt intake increased the risk of GC by 12%[ 53 ]. Excessive salt intake may destroy the gastric mucosa and increase DNA synthesis and cell proliferation to promote the development of GC[ 64 ], and excessive salt intake also acts synergistically with H. pylori to increase GC incidence[ 60 , 65 , 66 ]. However, no scientific evidence has confirmed a definite causal association between excessive salt intake and GC risk[ 60 ].…”
Section: Risk Factorsmentioning
confidence: 99%
“…For example, a 5 g/day increase in salt intake increased the risk of GC by 12%[ 53 ]. Excessive salt intake may destroy the gastric mucosa and increase DNA synthesis and cell proliferation to promote the development of GC[ 64 ], and excessive salt intake also acts synergistically with H. pylori to increase GC incidence[ 60 , 65 , 66 ]. However, no scientific evidence has confirmed a definite causal association between excessive salt intake and GC risk[ 60 ].…”
Section: Risk Factorsmentioning
confidence: 99%
“…(4) Participants who consumed more carbonated drinks tended to have reflux symptoms ( 22 ). (5) Carbonated drink usually contained more sugar, which could lead to obesity ( 7 ). Obesity was conducive to chronic low-grade inflammation, hyperinsulinemia, hyperleptinemia, and an elevated production of endogenous sex steroid hormones, all of which might contribute to tumor growth ( 7 ).…”
Section: Discussionmentioning
confidence: 99%
“…(3) Subjects who have lived in the local area for more than 10 years; (4) Subjects were not to be given a diagnosis of other malignant tumors; (5) The diagnostic criteria were consistent with the 2019 Chinese Cancer Registry Annual Report (ICD-10/C16). Cases were excluded according to the following criteria: (1) cases were diagnosed as gastric cancer before January 1, 2020; (2) Subjects who were unable to participate in the investigation due to health problems; (3) Subjects who were unable to cooperate in the investigation due to serious illness or other reasons; (4) having a medical disease that influenced language function or movement; (5) Subjects who have not lived in the local area for more than 10 years, or could not return to the local area for other reasons such as migrant work; (6) Subjects were to be given a diagnosis of other types of cancers; (7) The diagnostic criteria were different from the 2019 Chinese Cancer Registry Annual Report. Controls were included according to the following criteria: (1) The age difference between cases and controls was within 5 years; (2) the absence of mental disorders or cognition dysfunction; (3) Subjects who have lived in the local area for more than 10 years; (4) Subjects were not to be given a diagnosis of malignant tumors.…”
Section: Inclusion Criteria and Exclusion Criteriamentioning
confidence: 99%
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“…This indicates that high dietary salt intake could enhance the carcinogenic effects of cagA+ H. pylori strains [ 14 ]. (5) High salt intake could alter the viscosity of the protective mucous barrier, disrupt immune homeostasis, and increase susceptibility to H. pylori infection [ 11 , 56 , 57 ]. These factors would result in chronic inflammation, such as atrophic gastritis and gastric ulcers both of which are common precancerous diseases [ 13 , 14 , 56 , 58 ].…”
Section: Discussionmentioning
confidence: 99%