Diet and risk of multiple myeloma in Connecticut women

Abstract

Multiple myeloma accounts for an estimated 19,900 incident cancer cases per year in the United States. A population-based case-control study, consisting of 179 incident cases and 691 controls, was conducted to examine the impact of diet on multiple myeloma risk. Diet was assessed using a food frequency questionnaire and odds ratios, 95% confidence intervals, and P-trends were calculated across quartiles of consumption. After controlling for potential confounders, we observed inverse associations for cooked tomatoes (P-trend = 0.002), cruciferous vegetables (P-trend = 0.01), fresh fish (P-trend < 0.001), alcohol (P-trend < 0.001), and vitamin A (P-trend < 0.001) with multiple myeloma risk. In contrast, consumption of cream soups (P-trend = 0.01), jello (P-trend = 0.01), ice cream (P-trend = 0.01), and pudding (P-trend < 0.001) were positively associated with multiple myeloma. Furthermore, there was a suggestion that carbohydrate intake may be positively associated, whereas vitamin D and calcium intake may be inversely associated, with multiple myeloma risk. Despite very limited data on dietary factors in relation to multiple myeloma, the findings from this study concur with previously published studies, suggesting an inverse association for consumption of fish, cruciferous vegetables and green vegetables, and a positive association for some dairy products.

Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma

“…Our analysis included data and specimens with cases identified from the Surveillance, Epidemiology, and End Results (SEER) programs of the greater Seattle/Puget Sound and Detroit regions, as well as the Yale Comprehensive Cancer Center’s Rapid Case Ascertainment Shared Resource, a component of the Connecticut Tumor Registry [38,39]. Eligible cases were residents of the Seattle/Puget Sound region, Detroit metropolitan area, or the state of Connecticut, aged 35–74 years, with a diagnosis of MM (ICD-O-2 M9731:2) made between 2000 and 2002 in Seattle and Detroit and between 1996 and 2002 in Connecticut.…”

A Pooled Analysis of Alcohol Consumption and Risk of Multiple Myeloma in the International Multiple Myeloma Consortium

“…Established risk factors include older age, male sex, African ancestry, and obesity. 2 Findings suggestive of a protective effect of alcohol consumption on MM risk are less consistent, as demonstrated in some case-control studies 3-6 and cohort investigations, 7-10 but not others. 11-14 Given the rarity of MM many of these past investigations had limited statistical power to detect an alcohol effect of moderate size.…”

Association of Alcohol Intake with the Risk of Malignant Lymphoma and Plasma Cell Myeloma in Japanese: A Population-Based Cohort Study (Japan Public Health Center–based Prospective Study)

“…Most studies reported an inverse association between alcohol consumption and the risk of ML (1)(2)(3)(4)(5)(6), but reported inconsistent results with regard to that of PCM (6)(7)(8)(9). In contrast to the number of studies in Western populations, however, little research has been conducted in Asian populations.…”