Diet/Energy Balance Affect Sleep and Wakefulness Independent of Body Weight

Perron, Isaac J.; Pack, Allan I.; Veasey, Sigrid C.

doi:10.5665/sleep.5236

Cited by 23 publications

(35 citation statements)

References 38 publications

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“…A recent study reported that one-week ad libitum feeding with increased calorie density (high fat diet) resulted in increased sleep/wake fragmentation in mice [11], which indicates a link between excessive energy consumption and disturbed sleep. A human study of acute diet alteration in normal sleepers has shown that, compared to limited total energy intake, sleep after ad libitum feeding was characterized by longer SOL and shorter slow wave sleep [10].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Six-Month Diet Intervention on Sleep among Overweight and Obese Men with Chronic Insomnia Symptoms: A Randomized Controlled Trial

et al. 2016

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Growing evidence suggests that diet alteration affects sleep, but this has not yet been studied in adults with insomnia symptoms. We aimed to determine the effect of a six-month diet intervention on sleep among overweight and obese (Body mass index, BMI ≥ 25 kg/m2) men with chronic insomnia symptoms. Forty-nine men aged 30–65 years with chronic insomnia symptoms were randomized into diet (n = 28) or control (n = 21) groups. The diet group underwent a six-month individualized diet intervention with three face-to-face counseling sessions and online supervision 1–3 times per week; 300–500 kcal/day less energy intake and optimized nutrient composition were recommended. Controls were instructed to maintain their habitual lifestyle. Sleep parameters were determined by piezoelectric bed sensors, a sleep diary, and a Basic Nordic sleep questionnaire. Compared to the controls, the diet group had shorter objective sleep onset latency after intervention. Within the diet group, prolonged objective total sleep time, improved objective sleep efficiency, lower depression score, less subjective nocturnal awakenings, and nocturia were found after intervention. In conclusion, modest energy restriction and optimized nutrient composition shorten sleep onset latency in overweight and obese men with insomnia symptoms.

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Section: Discussionmentioning

confidence: 99%

“…Diet is an important mediator between sleep and overweight/obesity. Growing evidence suggest that diet alterations can directly influence sleep parameters [10,11]. Furthermore, the associations between nutrients and insomnia symptoms have been reported by recent studies [12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Six-Month Diet Intervention on Sleep among Overweight and Obese Men with Chronic Insomnia Symptoms: A Randomized Controlled Trial

et al. 2016

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“…Surgery for EEG/EMG (electromyography) recording and data acquisition and analysis were performed as previously described ( 32 , 33 ). Briefly, EEG/EMG headmounts were manually constructed and implanted onto mice anesthetized with ketamine (100 mg/kg) and xylene (10 mg/kg).…”

Section: Methodsmentioning

confidence: 99%

Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7

et al. 2017

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“…Sleep recordings were conducted as previously described (Perron, Pack & Veasey, ). Briefly, silver wire electrodes were soldered to gold sockets and push fit into 6‐channel plastic holders.…”

Section: Methodsmentioning

confidence: 99%

The leptin sensitizer celastrol reduces age‐associated obesity and modulates behavioral rhythms

et al. 2019

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The prevalence of obesity increases with age in humans and in rodents. Age‐related obesity is characterized by leptin resistance and associated with heightened risk of metabolic disorders. However, the effect of leptin resistance per se has been difficult to disentangle from other effects of aging. Here we demonstrate that celastrol, a natural phytochemical that was previously shown to act as a leptin sensitizer, induces weight loss in aged animals, but not in young controls. Celastrol reduces food intake and lowers fasting glucose without affecting energy expenditure. Unexpectedly, administration of celastrol just before the dark period disrupted circadian rhythms of sleep and activity. This regimen was also associated with loss of lean mass an outcome that would not be desirable in elderly patients. Adjusting the timing of celastrol administration by 12 hr, to the beginning of the light period, avoided interference with circadian rhythms while retaining the reductions in body weight and adiposity. Thus, targeting leptin signaling is an effective strategy to ameliorate age‐associated weight gain, and can profoundly impact circadian rhythms.

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Diet/Energy Balance Affect Sleep and Wakefulness Independent of Body Weight

Abstract: Acute dietary manipulations are sufficient to alter sleep and wakefulness independent of body weight and without effects on sleep homeostasis.

Cited by 23 publications

References 38 publications

Effect of Six-Month Diet Intervention on Sleep among Overweight and Obese Men with Chronic Insomnia Symptoms: A Randomized Controlled Trial

Effect of Six-Month Diet Intervention on Sleep among Overweight and Obese Men with Chronic Insomnia Symptoms: A Randomized Controlled Trial

Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7

The leptin sensitizer celastrol reduces age‐associated obesity and modulates behavioral rhythms

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