Diet-Gut Microbiota Interactions and Gestational Diabetes Mellitus (GDM)

Ponzo, Valentina; Fedele, D.; Goitre, Ilaria; Leone, Filomena; Lezo, Antonela; Monzeglio, C; Finocchiaro, Concetta; Ghigo, Ezio; Bo, Simona

doi:10.3390/nu11020330

Cited by 118 publications

(133 citation statements)

References 100 publications

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“…18 GDM is typically diagnosed at approximately 24-28 gestational weeks, and patients may receive exercise-, dietary-, and/or pharmacological-based interventions, which could be the underlying explanation for the discrepant findings. 32 Further, Crusell et al found that different species of Faecalibacterium were both enriched and depleted in GDM women and this alteration was influenced by the adjustment for prepregnancy BMI, suggesting that different strains of Faecalibacterium are involved. 31 Faecalibacterium is a butyrate-producer with anti-inflammatory effects and has been shown previously to be reduced in the third trimester of healthy women compared to earlier in pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Perturbations of gut microbiota in gestational diabetes mellitus patients induce hyperglycemia in germ-free mice

Qin

Feng

et al. 2020

J Dev Orig Health Dis

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Shifts in the maternal gut microbiota have been implicated in the development of gestational diabetes mellitus (GDM). Understanding the interaction between gut microbiota and host glucose metabolism will provide a new target of prediction and treatment. In this nested case-control study, we aimed to investigate the causal effects of gut microbiota from GDM patients on the glucose metabolism of germ-free (GF) mice. Stool and peripheral blood samples, as well as clinical information, were collected from 45 GDM patients and 45 healthy controls (matched by age and prepregnancy body mass index (BMI)) in the first and second trimester. Gut microbiota profiles were explored by next-generation sequencing of the 16S rRNA gene, and inflammatory factors in peripheral blood were analyzed by enzyme-linked immunosorbent assay. Fecal samples from GDM and non-GDM donors were transferred to GF mice. The gut microbiota of women with GDM showed reduced richness, specifically decreased Bacteroides and Akkermansia, as well as increased Faecalibacterium. The relative abundance of Akkermansia was negatively associated with blood glucose levels, and the relative abundance of Faecalibacterium was positively related to inflammatory factor concentrations. The transfer of fecal microbiota from GDM and non-GDM donors to GF mice resulted in different gut microbiota colonization patterns, and hyperglycemia was induced in mice that received GDM donor microbiota. These results suggested that the shifting pattern of gut microbiota in GDM patients contributed to disease pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Perturbations of gut microbiota in gestational diabetes mellitus patients induce hyperglycemia in germ-free mice

Qin

Feng

et al. 2020

J Dev Orig Health Dis

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“…Interesting studies report that MI can prevent the development of GDM by improving glucose metabolism in PCOS patients (126,182). In this condition, a diet rich in fat-soluble vitamins, fiber, and antioxidants may play a positive role (183). For example, chronic consumption of quercetin, a flavonoid antioxidant, seems to alleviate fasting and postprandial hyperglycemia in animal models of DM, in part by inhibiting α-glucosidase activity (184).…”

Section: Expert Opinionmentioning

confidence: 99%

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

et al. 2020

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Polycystic ovary syndrome (PCOS) is a very common endocrine and metabolic disorder with the involvement of both genetic and environmental factors. Although much has been clarified on its pathogenesis, diagnosis, clinical manifestations, and therapy, there are still areas of uncertainty. To address fundamental concepts, novel aspects and hypotheses, and future perspectives, including the possible additional benefits of treatment with nutraceuticals, an expert consensus panel formed by endocrinologists and gynecologists was established. After an independent review of the literature, the panel convened electronically on February 3, 2020, and six resolutions were created, debated, and agreed upon discussion, and finally approved in their final form in a consensus livestream meeting held on April 15. The summary of the resolutions are: (1) PCOS is a well-established medical condition that negatively affects reproduction, general health, sexual health, and quality of life; (2) the symptoms and signs of PCOS appear early in life especially in female newborns from PCOS carriers; (3) women with PCOS have significantly increased risk of pregnancy-related complications including gestational diabetes mellitus; (4) a male PCOS equivalent exists, and it may impact on metabolic health and probably on reproduction; (5) the evidence supports that medical therapy for PCOS is effective, rational, and evidence-based; (6) the evidence supports a major research initiative to explore possible benefits of nutraceutical therapy for PCOS. The proposed resolutions may be regarded as points of agreement based on the current scientific evidence available.

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“…Gestational diabetes mellitus (GDM) is associated with altered gut microbiota in pregnant women, 169 including Bifidobacterium spp 170 . Moreover, it has been shown that this GDM‐related dysbiosis can be vertically transmitted to the offspring 171 .…”

Section: Maternal and Early‐life Factors Influencing Maternal Milk Comentioning

confidence: 99%

Early‐Life Gut Microbiome—The Importance of Maternal and Infant Factors in Its Establishment

Kapourchali

Cresci

2020

Nut in Clin Prac

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The early-life microbiome is gaining appreciation as a major influencer in human development and long-term health. Multiple factors are known to influence the initial colonization, development, and function of the neonatal gut microbiome. In addition, alterations in early-life gut microbial composition is associated with several chronic health conditions such as obesity, asthma, and allergies. In this review, we focus on both maternal and infant factors known to influence early-life gut colonization. Also reviewed is the important role of infant feeding, including evidence-based strategies for maternal and infant supplementation with the goal to protect and/or restore the infant gut microbiome.

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Diet-Gut Microbiota Interactions and Gestational Diabetes Mellitus (GDM)

Cited by 118 publications

References 100 publications

Perturbations of gut microbiota in gestational diabetes mellitus patients induce hyperglycemia in germ-free mice

Perturbations of gut microbiota in gestational diabetes mellitus patients induce hyperglycemia in germ-free mice

Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions

Early‐Life Gut Microbiome—The Importance of Maternal and Infant Factors in Its Establishment

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