Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population

Romeu, Marta; Aranda, Núria; Giralt, Mireia; Ribot, Blanca; Nogués, María Rosa; Arija, Victoria

doi:10.1186/1475-2891-12-102

Cited by 46 publications

(44 citation statements)

References 27 publications

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“…Evidence suggests higher intakes of red meat are associated with elevated markers of oxidative stress [35,36]. Our findings are consistent with previous research in this area [10,11,12,13]; however, there is minimal evidence for an impact of dietary meat intake on glaucoma [11].…”

Section: Discussionsupporting

confidence: 91%

The Association between Dietary Intake of Antioxidants and Ocular Disease

2017

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Abstract:To assess the association between dietary antioxidant intake and the incidence of the three major oxidative stress-related eye diseases, cataracts, glaucoma, and age-related macular degeneration, 78 cases from the University of Auckland Optometry and Vision Science clinic and 149 controls were recruited. Participants completed an antioxidant food-frequency questionnaire, analysed through multiple logistic regression. Protective associations were identified with higher consumption of fruit and vegetables (OR = 0.99; 95% CI: 0.98, 1.00; p = 0.004), vitamin C (OR = 0.63; 95% CI: 0.23, 1.03; p = 0.022), and β-carotene (OR = 0.56; 95% CI: 0.15, 0.98; p = 0.007). Meanwhile, harmful associations were observed with greater consumption of meat/nuts (OR = 1.03; 95% CI: 1.01, 1.05; p = 0.006) and cholesterol (OR = 1.09; 95% CI: 1.50, 2.46; p = 0.005). Diets rich in fruit and vegetables appear to be protective against cataracts, glaucoma, and age-related macular degeneration, while diets higher in meat and nuts may increase the risk of oxidative stress-related eye diseases. In addition, higher intakes of vitamin C and β-carotene from food, with reduction of dietary cholesterol intake, may be beneficial towards the outcome of oxidative stress-related eye diseases.

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Section: Discussionsupporting

confidence: 91%

The Association between Dietary Intake of Antioxidants and Ocular Disease

2017

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“…One hypothesis is that constituents, such as nitrate, nitrite, heme iron and their by-products, in both unprocessed and processed meat could act as mediators between dietary intake and cardiovascular and metabolic homeostasis 36. Heme iron is associated with increased oxidative stress and insulin resistance 47. Nitrate and nitrite have been associated with endothelial dysfunction and insulin resistance 48.…”

Section: Discussionmentioning

confidence: 99%

Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: the Rotterdam Study

Alferink

Jong

Erler

et al. 2018

Gut

110

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ObjectiveA healthy lifestyle is the first-line treatment in non-alcoholic fatty liver disease (NAFLD), but specific dietary recommendations are lacking. Therefore, we aimed to determine whether dietary macronutrient composition is associated with NAFLD.DesignParticipants from the Rotterdam Study were assessed on (1) average intake of macronutrients (protein, carbohydrate, fat, fibre) using a Food Frequency Questionnaire and (2) NAFLD presence using ultrasonography, in absence of excessive alcohol, steatogenic drugs and viral hepatitis. Macronutrients were analysed using the nutrient density method and ranked (Q1–Q4). Logistic regression analyses were adjusted for sociodemographic, lifestyle and metabolic covariates. Moreover, analyses were adjusted for and stratified by body mass index (BMI) (25 kg/m2). Also, substitution models were built.ResultsIn total, 3882 participants were included (age 70±9, 58% female). NAFLD was present in 1337 (34%) participants of whom 132 were lean and 1205 overweight. Total protein was associated with overweight NAFLD after adjustment for sociodemographic and lifestyle covariates (ORQ4vsQ1 1.40; 95% CI 1.11 to 1.77). This association was driven by animal protein (ORQ4vsQ1 1.54; 95% CI 1.20 to 1.98). After adjustment for metabolic covariates, only animal protein remained associated with overweight NAFLD (ORQ4vsQ1 1.36; 95% CI 1.05 to 1.77). Monosaccharides and disaccharides were associated with lower overall NAFLD prevalence (ORQ4vsQ1 0.66; 95% CI 0.52 to 0.83) but this effect diminished after adjustment for metabolic covariates and BMI. No consistent associations were observed for fat subtypes or fibre. There were no substitution effects.ConclusionThis large population-based study shows that high animal protein intake is associated with NAFLD in overweight, predominantly aged Caucasians, independently of well-known risk factors. Contrary to previous literature, our results do not support a harmful association of monosaccharides and disaccharides with NAFLD.

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“…A high level of iron in the brain has been linked to neurodegenerative disorders including Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, and Huntington's disease [6], and a number of trace metals including iron have been associated with the risk of cancer [7]. Men tend to have higher levels of iron than premenopausal women who experience menstrual blood loss and pregnancy [8, 9]. Men are also more likely develop glioma, with the greatest difference in incidence across genders occurring during the reproductive years [10].…”

Section: Introductionmentioning

confidence: 99%

Toenail iron, genetic determinants of iron status, and the risk of glioma

Anic

Madden

Thompson

et al. 2013

Cancer Causes Control

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Purpose Iron is essential for oxygen transport and oxidative metabolism; however, elevated iron stores can trigger overproduction of reactive oxygen species and induce DNA damage. Little is known about the association between body iron stores and glioma risk. This study examined associations of iron levels measured in toenails and genetic variants linked to body iron stores with risk of glioma in a clinic-based case-control study. Methods Samples were collected a median of 24 days following glioma diagnosis in the cases (10th-90th percentile range: 10-44 days). Nail iron levels were measured in 300 cases and 300 controls using neutron-activation analysis. A total of 24 genetic variants associated with iron status were genotyped in 622 cases and 628 controls. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for glioma risk according to toenail iron and the examined genotypes. Results No association was observed between toenail iron and glioma risk when restricting to cases with nails collected within ~3 weeks of diagnosis (OR=0.93; 95% CI: 0.46, 1.87 comparing those with high (≥ 14 μg/g) versus low (<6 μg/g) iron levels). In contrast, an inverse association with increasing iron was observed after restricting to cases with a delay of 3 weeks or greater (OR=0.42; 95% CI: 0.19, 0.95) reflecting potentially insidious effects of advancing disease on iron levels among the cases. No associations were observed for any of the examined genetic variants. Conclusion The results do not support a role for body iron stores as a determinant of glioma risk.

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Diet, iron biomarkers and oxidative stress in a representative sample of Mediterranean population

Cited by 46 publications

References 27 publications

The Association between Dietary Intake of Antioxidants and Ocular Disease

The Association between Dietary Intake of Antioxidants and Ocular Disease

Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: the Rotterdam Study

Toenail iron, genetic determinants of iron status, and the risk of glioma

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