Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome as Well as Traditional Dietary Advice: A Randomized Controlled Trial

Böhn, Lena; Störsrud, Stine; Liljebo, Therese; Collin, Lena; Lindfors, Perjohan; Törnblom, Hans; Simrén, Magnus

doi:10.1053/j.gastro.2015.07.054

Cited by 505 publications

(621 citation statements)

References 45 publications

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“…ingestion of three meals and three snacks daily; decreased consumption of fatty or spicy foods, coffee, alcohol, cabbage, onions, and beans; avoidance of carbonated beverages) in patients with IBS. The study reported that the intensity of IBS symptoms was significantly decreased from baseline with both interventions after 29 days (P < 0.001) [52]. A meta-analysis of 10 prospective clinical studies of the low FODMAP diet in patients with IBS showed that a standard IBS diet (high FODMAP) and low FODMAP diet were both efficacious for improving IBS symptoms [53].…”

Section: Low Fodmap Dietmentioning

confidence: 99%

“…gluten-free, low FODMAP) appear to be efficacious because of improvements in global and individual IBS symptoms in patients, but more evidence is needed before dietary restriction can be strongly recommended for these patients [56]. Although clinical trial data support that the reduction of FODMAPs is beneficial for patients with IBS [52,54,57], long-term adherence to a strict low FODMAP diet is not recommended because of nutritional concerns and potential effects on the gut microbiota [58]; rather, excluded components of the diet should be slowly reintroduced until satisfactory symptom control is maintained by the individual patient [59]. Interestingly, a study conducted in England reported that primary care physicians (PCPs) generally recommend dietary modification first to patients with IBS [60], but based on the very low quality of evidence, the American College of Gastroenterology (ACG) makes only a weak recommendation for specialized diets in the management of IBS [1].…”

Section: Low Fodmap Dietmentioning

confidence: 99%

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Modulation of the gut microbiota: a focus on treatments for irritable bowel syndrome

Harris

Baffy

2017

Postgraduate Medicine

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Irritable bowel syndrome (IBS), which is characterized by recurrent abdominal pain and disordered bowel habits, is one of the most common functional bowel disorders. IBS is a substantial burden on both patient health-related quality of life and healthcare costs. Several pathophysiologic mechanisms have been postulated for the occurrence of IBS, including altered gastrointestinal motility, visceral hypersensitivity, changes in gut permeability, immune activation, gut-brain dysregulation, central nervous system dysfunction, and changes in the gut microbiota. Of note, both qualitative and quantitative differences have been observed in the gut microbiota of a population with IBS versus a healthy population. Because of the substantial interest in the gut microbiota and its role as a therapeutic target in IBS, this article provides an overview of specific interventions with the potential to modulate the gut microbiota in IBS, including elimination diets, prebiotics, probiotics, synbiotics, and nonsystemic antibiotics. Although probiotics and synbiotics are generally well tolerated, differences in the composition and concentration of different bacterial species and inclusion or exclusion of prebiotic components varies widely across studies and has prevented strong recommendations on their use in IBS. For nonsystemic antibiotics, rifaximin is indicated in the United States for the treatment of IBS with diarrhea in adults and has been shown to be efficacious and well tolerated in well-designed clinical trials. Overall, more consistent evidence is needed regarding the efficacy and safety of elimination diets, prebiotics, probiotics, and synbiotics for the treatment of patients with IBS. Furthermore, additional well-designed studies are needed that examine alterations in the gut microbiota that occur with these interventions and their potential associations with clinical symptoms of IBS. ARTICLE HISTORY

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Section: Low Fodmap Dietmentioning

confidence: 99%

Section: Low Fodmap Dietmentioning

confidence: 99%

Modulation of the gut microbiota: a focus on treatments for irritable bowel syndrome

Harris

Baffy

2017

Postgraduate Medicine

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“…Randomized controlled trials (RCTs) reported that a diet low in FODMAPS effectively reduced IBS symptoms, and the effects were comparable with those of the traditional IBS dietary advice. 26,27 FODMAPs exacerbate IBS symptoms through various mechanisms, such as by increasing the small-intestinal water volume through an osmotic effect, colonic-gas production by bacterial fermentation, and altered intestinal motility. 28 Carbohydrates fermented by the gut microbiota cause increased production of luminal gases, such as hydrogen, methane, and carbon dioxide.…”

Section: Diet and Intestinal Microbiotamentioning

confidence: 99%

Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders

Lee

Choi

Ryu

et al. 2017

J Neurogastroenterol Motil

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Functional bowel disorders (FBDs) are functional gastrointestinal disorders with symptoms attributable to the middle or lower gastrointestinal tract. These include irritable bowel syndrome, functional bloating, functional constipation, functional diarrhea, and unspecified FBD. Increasing evidence has emerged of late that intestinal microbiota is involved in the pathogenesis of FBDs. In this review, the therapeutic benefits and future perspectives of the currently available strategies for modifying the gut microbiota in FBDs are described, focusing primarily on irritable bowel syndrome and functional constipation.

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“…Sugeruje się, że połączenie strategii FOD-MAP z tradycyjnymi zaleceniami dietetycznymi może być skutecznym sposobem na redukcję objawów z.j.d. [28]. Potrzebne są jednak dalsze badania na większej populacji pacjentów oceniające długo-terminowe skutki stosowania diety o małej zawartości FODMAP.…”

Section: Alternatywne Diety Eliminacyjneunclassified

New Trends in the Dietary Treatment of Inflammatory Bowel Diseases

Włochal¹,

Grzymisławski²

2016

Piel. Zdr. Publ.

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Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome as Well as Traditional Dietary Advice: A Randomized Controlled Trial

Cited by 505 publications

References 45 publications

Modulation of the gut microbiota: a focus on treatments for irritable bowel syndrome

Modulation of the gut microbiota: a focus on treatments for irritable bowel syndrome

Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders

New Trends in the Dietary Treatment of Inflammatory Bowel Diseases

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