Diet-Microbiota Interactions Underlie Symptoms' Generation in IBS

Palma, Giada De; Reed, David E.; Pigrau, Marc; Lü, Jun; Sidani, Sacha; Zhang, Yong; Yu, Yang; Jiménez-Vargas, Nestor N.; Sessenwein, Jessica; Lopez, Cintya D. Lopez; Polanco, Josue O. Jaramillo; Verdú, Elena F.; Collins, Stephen M.; Lomax, Alan; Beyak, Michael; Vanner, Stephen; Berčík, Přemysl

doi:10.1016/s0016-5085(17)30855-7

Cited by 3 publications

(6 citation statements)

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“…Our recent data show that the gut microbiota from some patients with IBS can produce large amounts of histamine, and that the microbial histamine production is dependent on the fermentative milieu in the colon. 57,58 Consequently, a low fermentable diet decreases histamine production in mice colonized with IBS microbiota, similar to what we observed in IBS patients placed on a low FODMAP diet. 57,58 Bacterial histamine production leads to colonic mast cell hyperplasia and visceral hyperalgesia in microbiotahumanized mouse model, and this process is dependent on H4-receptor pathways.…”

Section: Mechanis Ms Underlying Effic Ac Y Of a Low Fodmap D Ie Tsupporting

confidence: 84%

“…57,58 Consequently, a low fermentable diet decreases histamine production in mice colonized with IBS microbiota, similar to what we observed in IBS patients placed on a low FODMAP diet. 57,58 Bacterial histamine production leads to colonic mast cell hyperplasia and visceral hyperalgesia in microbiotahumanized mouse model, and this process is dependent on H4-receptor pathways. 57,59,60 These data suggest that histamine of both host and microbial origin plays a key role in chronic abdominal pain and gut dysfunction.…”

Section: Mechanis Ms Underlying Effic Ac Y Of a Low Fodmap D Ie Tsupporting

confidence: 84%

“…In addition, the role of bacterial histamine in IBS symptoms should be also considered. Our recent data show that the gut microbiota from some patients with IBS can produce large amounts of histamine, and that the microbial histamine production is dependent on the fermentative milieu in the colon 57,58 . Consequently, a low fermentable diet decreases histamine production in mice colonized with IBS microbiota, similar to what we observed in IBS patients placed on a low FODMAP diet 57,58 .…”

Section: Mechanisms Underlying Efficacy Of a Low Fodmap Dietsupporting

confidence: 80%

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Long‐term personalized low FODMAP diet in IBS

Palma

Berčík

2022

Neurogastroenterology Motil

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Irritable bowel syndrome (IBS) patients often resort to dietary interventions to manage their symptoms, as these are frequently exacerbated by various food items. A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) is now considered by many a first‐line treatment option for IBS, as it has been found to be superior to alternative dietary interventions. However, concerns have been raised as restricting fermentable carbohydrates might result in nutritional deficits or alter composition and function of the gut microbiome in the long term. The study by Staudacher et al., published in this issue of the journal, is the first prospective study to follow IBS patients after completing all three phases of the low FODMAPs diet (restriction, reintroduction, and personalization), demonstrating that this is safe and effective in long‐term, when patients are supervised by a dietician. This mini‐review provides an up‐to‐date overview of the use of fermentable carbohydrate's restrictions for symptom management in IBS patients, while summarizing the current knowledge on the possible mechanisms of action behind low fermentable carbohydrate diet efficacy.

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Section: Mechanis Ms Underlying Effic Ac Y Of a Low Fodmap D Ie Tsupporting

confidence: 84%

Section: Mechanis Ms Underlying Effic Ac Y Of a Low Fodmap D Ie Tsupporting

confidence: 84%

Section: Mechanisms Underlying Efficacy Of a Low Fodmap Dietsupporting

confidence: 80%

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Long‐term personalized low FODMAP diet in IBS

Palma

Berčík

2022

Neurogastroenterology Motil

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“…19 Possible mechanisms include a decrease in osmotic diarrhoea, fermentation and altered gut microbiota, immune activation and visceral sensitivity. 21,22 Statement 9: Other dietary concerns that may affect IBS include lactose intolerance, high-fat diet, high-fibre diet, chilli, and gluten.…”

Section: Rome III Rome Ivmentioning

confidence: 99%

The current treatment landscape of irritable bowel syndrome in adults in Hong Kong: consensus statements

Chan

et al. 2017

Hong Kong Med J

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“…While much of the data for the low FODMAP and gluten-free diets come from clinical trials, which suffer from some limitations, researchers are now turning to animal models to better understand the mechanisms underlying dietary-induced changes 11,12 . A major advantage of animal studies is the ability to maintain stringent control of dietary composition.…”

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confidence: 99%

Nutritional profile of rodent diets impacts experimental reproducibility in microbiome preclinical research

Tuck

Palma

Takami

et al. 2020

Sci Rep

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The lack of reproducibility of animal experimental results between laboratories, particularly in studies investigating the microbiota, has raised concern among the scientific community. Factors such as environment, stress and sex have been identified as contributors, whereas dietary composition has received less attention. This study firstly evaluated the use of commercially available rodent diets across research institutions, with 28 different diets reported by 45 survey respondents. Secondly, highly variable ingredient, FODMAP (Fermentable Oligo-, Di-, Mono-saccharides And Polyols) and gluten content was found between different commercially available rodent diets. Finally, 40 mice were randomized to four groups, each receiving a different commercially available rodent diet, and the dietary impact on cecal microbiota, short- and branched-chain fatty acid profiles was evaluated. The gut microbiota composition differed significantly between diets and sexes, with significantly different clusters in β-diversity. Total BCFA were highest (p = 0.01) and SCFA were lowest (p = 0.03) in mice fed a diet lower in FODMAPs and gluten. These results suggest that nutritional composition of commercially available rodent diets impact gut microbiota profiles and fermentation patterns, with major implications for the reproducibility of results across laboratories. However, further studies are required to elucidate the specific dietary factors driving these changes.

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Diet-Microbiota Interactions Underlie Symptoms' Generation in IBS

Cited by 3 publications

References 0 publications

Long‐term personalized low FODMAP diet in IBS

Long‐term personalized low FODMAP diet in IBS

The current treatment landscape of irritable bowel syndrome in adults in Hong Kong: consensus statements

Nutritional profile of rodent diets impacts experimental reproducibility in microbiome preclinical research

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