Diet, nutrition and telomere length

Paul, Ligi

doi:10.1016/j.jnutbio.2010.12.001

Cited by 195 publications

(153 citation statements)

References 111 publications

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“…A villager received a score of 1 if she/he had a BSI score >75th percentile, and 0 otherwise. Because other factors contribute to telomere shortening, including smoking (97), diet, and nutritional deficiencies (98), and certain diseases (99), the survey also included measures of tobacco/bidi use (₹100 units), animal protein consumption (₹100 units), household income (₹1,000 units), demographic characteristics (age and sex of respondent), and whether or not a respondent suffered a malaria incident in the last 30 d.…”

Section: Methodsmentioning

confidence: 99%

“…In addition to the above corrections for clustering, to isolate the unique relationships between stress measures and telomere shortening, our analyses control for a variety of person-level correlates likely associated with shortened telomeres, including smoking (97), diet and nutritional deficiencies (98), disease burden (malaria in this case) (99), SES (36), and demographic characteristics of respondents (17)(18)(19)33). Our models also controlled for the count of telomeres retrieved per cell to overcome a selection bias common to cytological imaging procedures of this kind, ‡ as well as the count of cells sampled per person.…”

Section: Research Hypotheses and Analytical Planmentioning

confidence: 99%

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Stress and telomere shortening among central Indian conservation refugees

Zahran

Snodgrass

Maranon

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Research links psychosocial stress to premature telomere shortening and accelerated human aging; however, this association has only been demonstrated in so-called "WEIRD" societies (Western, educated, industrialized, rich, and democratic), where stress is typically lower and life expectancies longer. By contrast, we examine stress and telomere shortening in a non-Western setting among a highly stressed population with overall lower life expectancies: poor indigenous people-the Sahariya-who were displaced (between 1998 and 2002) from their ancestral homes in a central Indian wildlife sanctuary. In this setting, we examined adult populations in two representative villages, one relocated to accommodate the introduction of Asiatic lions into the sanctuary (n = 24 individuals), and the other newly isolated in the sanctuary buffer zone after their previous neighbors were moved (n = 22). Our research strategy combined physical stress measures via the salivary analytes cortisol and α-amylase with self-assessments of psychosomatic stress, ethnographic observations, and telomere length assessment [telomere-fluorescence in situ hybridization (TEL-FISH) coupled with 3D imaging of buccal cell nuclei], providing high-resolution data amenable to multilevel statistical analysis. Consistent with expectations, we found significant associations between each of our stress measures-the two salivary analytes and the psychosomatic symptom survey-and telomere length, after adjusting for relevant behavioral, health, and demographic traits. As the first study (to our knowledge) to link stress to telomere length in a non-WEIRD population, our research strengthens the case for stress-induced telomere shortening as a pancultural biomarker of compromised health and aging.telomeres | stress | India | indigenous peoples | human displacement P sychosocial stress is associated with elevated risk for a range of human diseases and curtailment of human life expectancy (1-16). Telomeres-repetitive and stabilizing features of chromosomal termini that cap and protect them-have also been shown to be associated with aging and disease (17)(18)(19). Telomere length erodes normally with cell division and generally with aging, triggering cellular senescence once telomere length eclipses a threshold, contributing to tissue degeneration and organ decline with longevity (20-25). Given evidence that stress can elevate the risk of human mortality, and that premature telomere shortening can serve as a proxy for increased risk of disease and mortality, it is reasonable to posit that stress is also associated with telomere shortening (23,26,27). Indeed, research provides evidence of telomere shortening in a range of stress-inducing life situations, including among primary caregivers of chronically ill children and Alzheimer's patients (28, 29), children spending more time in orphanages or experiencing other forms of neglect and adversity (30-32), women suffering from intimate partner violence (33), patients suffering from stress-related mood disorders (34, 35), and...

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Section: Methodsmentioning

confidence: 99%

Section: Research Hypotheses and Analytical Planmentioning

confidence: 99%

Stress and telomere shortening among central Indian conservation refugees

Zahran

Snodgrass

Maranon

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…Es posible que el efecto de los nutrientes en la longitud del telómero esté influenciada por el sexo (54).…”

Section: Nutrientesunclassified

“…Así pues, estos factores son los que están implicados con enfermedades de muy diferente espectro que están relacionadas con los telómeros (48)(49)(50). Entre estas enfermedades están las ligadas al envejecimiento: enfermedades de tipo cardiovascular (infarto de miocardio, enfermedad cerebrovascular, enfermedad arterial periférica) (27,36), cirrosis hepática, hipertensión, aterosclerosis, diabetes, cáncer y enfermedades neurodegenerativas (alzhéimer, párkinson) (14,(51)(52)(53)(54). La longitud de los telómeros predice la mortalidad y las enfermedades relacionadas con el envejecimiento (49).…”

Section: Introductionunclassified

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Marti¹,

Echeverría

Morell‐Azanza

et al. 2017

Nutr Hosp

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Palabras clave:Telómeros. Dieta mediterránea. Estrés oxidative. ADN. ResumenFundamento: existen pocos estudios que hayan evaluado la relación entre la calidad de la dieta y la integridad telómerica en humanos. Los telómeros son regiones de ADN no codificante que se encuentran en los extremos de los cromosomas, cuya longitud además de indicar la esperanza de vida, indica el estado global de salud. El objetivo de la presente revisión sistemática es recopilar la evidencia existente sobre la relación entre la longitud de los telómeros y la calidad de la dieta para conocer el impacto que algunos nutrientes, alimentos y patrones dietéticos pueden tener sobre la homeostasis telomérica y por lo tanto, sobre la salud en general. Material y métodos: se realizó una revisión bibliográfica en la base de datos PubMed para identificar los artículos publicados (en inglés o español) hasta diciembre de 2016 que cumplían los siguientes criterios: incluían sujetos humanos; eran estudios transversales; estudios de casos y controles; estudios de cohortes prospectivos o estudios de intervención; que evaluaban la relación de los nutrientes, alimentos o patrones dietéticos con la longitud de los telómeros. La estrategia de búsqueda incluía las siguientes palabras clave: nutrients or food OR food groups OR diet OR dietary pattern OR eating pattern OR dietary habits OR diet type AND telomere attrition OR telomere length. En total, se incluyeron 19 estudios transversales, cinco estudios de casos y controles, cinco estudios de cohortes prospectivos y dos estudios de intervención, incluyendo aquellos artículos que se encontraron por listas de referencias de otras publicaciones. Resultados: se encontraron asociaciones positivas entre la longitud de los telómeros y la adherencia a la dieta mediterránea y el consumo de verduras y frutas. Los resultados obtenidos para otros nutrientes, alimentos o patrones dietéticos fueron incoherentes, aunque parece que las carnes procesadas, los cereales, el alcohol y las bebidas endulzadas podrían estar asociados con telómeros más cortos. Conclusiones: la intervención dietética, y en particular la promoción de una dieta de estilo mediterráneo, podría desempeñar un papel en la protección de la integridad telomérica. Key words:Telomere. Mediterranean diet. Oxidative stress. DNA. AbstractBackground: Few studies have evaluated the relationship between diet quality and telomere integrity in humans. Telomeres are regions of non-coding DNA localized at the end of each chromosome whose length, in addition to indicating life expectancy, indicates an overall health status. The objective of this systematic review is to compile the existing evidence on the relationship between telomere length and diet quality to further explore the impact that some nutrients, foods and dietary patterns may have on telomere homeostasis and therefore, in precision nutrition strategies. Material and methods: A bibliographic review was performed in the PubMed database to identify published articles (in English or Spanish) until December 201...

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“…These mechanisms are implicated in cognition, eating disorders, depression, autism and schizophrenia (25,(31)(32)(33) . Studies on other epigenetic mechanisms involving RNA methylation, non-coding microRNA, telomere control and chromosomal position effects should also provide new understanding of mechanisms linking nutrition and brain health (23,34,35) .…”

Section: Nutrition and Gene Expression: Epigeneticsmentioning

confidence: 99%

Recent advances in nutrition, genes and brain health

Dauncey

2012

Proc. Nutr. Soc.

117

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Molecular mechanisms underlying brain structure and function are affected by nutrition throughout the life cycle, with profound implications for health and disease. Responses to nutrition are in turn influenced by individual differences in multiple target genes. Recent advances in genomics and epigenomics are increasing understanding of mechanisms by which nutrition and genes interact. This review starts with a short account of current knowledge on nutrition-gene interactions, focusing on the significance of epigenetics to nutritional regulation of gene expression, and the roles of SNP and copy number variants (CNV) in determining individual responses to nutrition. A critical assessment is then provided of recent advances in nutrition-gene interactions, and especially energy status, in three related areas: (i) mental health and well-being, (ii) mental disorders and schizophrenia, (iii) neurological (neurodevelopmental and neurodegenerative) disorders and Alzheimer's disease. Optimal energy status, including physical activity, has a positive role in mental health. By contrast, sub-optimal energy status, including undernutrition and overnutrition, is implicated in many disorders of mental health and neurology. These actions are mediated by changes in energy metabolism and multiple signalling molecules, e.g. brain-derived neurotrophic factor (BDNF). They often involve epigenetic mechanisms, including DNA methylation and histone modifications. Recent advances show that many brain disorders result from a sophisticated network of interactions between numerous environmental and genetic factors. Personal, social and economic costs of sub-optimal brain health are immense. Future advances in understanding the complex interactions between nutrition, genes and the brain should help to reduce these costs and enhance quality of life.

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Diet, nutrition and telomere length

Cited by 195 publications

References 111 publications

Stress and telomere shortening among central Indian conservation refugees

Stress and telomere shortening among central Indian conservation refugees

Telómeros Y Calidad De La Dieta: Una Revision Sistematica

Recent advances in nutrition, genes and brain health

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