Dietary advanced glycation end products restriction diminishes inflammation markers and oxidative stress in patients with type 2 diabetes mellitus

Abstract

The augmented consumption of dietary advanced glycation end products (dAGEs) has been associated with increased oxidative stress and inflammation, however, there is insufficient information over the effect on insulin resistance. The objective of the present study is to investigate the effect of dAGEs restriction on tumor necrosis factor-α (TNF-α), malondialdehyde, C-reactive protein (CRP), and insulin resistance in DM2 patients. We carried out a randomized 6 weeks prospective study in two groups of patients: subjects with a standard diet (n = 13), vs low dAGEs (n = 13). At the beginning and the end of study, we collected anthropometric measurements, and values of circulating glucose, HbA1c, lipids, insulin, serum AGEs, CRP, TNF-α and malondialdehyde. Anthropometric measurements, glucose, and lipids were similar in both groups at base line and at the end of the study. Estimation of basal dAGEs was similar in both groups; after 6 weeks it was unchanged in the standard group but in the low dAGEs group decreased by 44% (p<0.0002). Changes in TNF-α levels were different under standard diet (12.5 ± 14.7) as compared with low dAGEs (−18.36 ± 17.1, p<0.00001); changes in malondialdehyde were different in the respective groups (2.0 ± 2.61 and −0.83 ± 2.0, p<0.005) no changes were found for insulin levels or HOMA-IR. In conclusion, The dAGEs restriction decreased significantly TNF-α and malondialdehyde levels.

Dietary Advanced Glycation End Products and Their Role in Health and Disease

“…The results from published data describing the effects of introducing a low-AGE diet, as described above, for variable periods of time to different populations in different countries (40)(41)(42)(43)(44)(45)(46)(47)(48) are summarized in Table 2. Healthy subjects young and old, including patients with diabetes but not CKD, and patients with CKD but not diabetes, respond to this intervention with a substantial drop in circulating AGE concentrations.…”

Renovascular Hypertension Leads to DNA Damage and Apoptosis in Bone Marrow Cells

“…Enhanced levels of oxygen radicals, which characterize a state of oxidative stress, have been described in clinical and preclinical studies in many cardiovascular diseases, including diabetes, hypertension, and atherosclerosis (Minuz et al, 2002;Porto et al, 2011;Silva et al, 2012;Vasquez et al, 2012;Luévano-Contreras et al, 2013). Indeed, an excess of either molecular oxygen or chemical derivatives of oxygen (Kodja and Harrison, 1999) may be a common underlying pathogenic mechanism in these diseases.…”

Could Advanced Glycation End Products Explain the Poor Response to Controlled Ovarian Hyperstimulation in Obese Women?

“…The AGE-RAGE system plays an important role in modulating systemic inflammation [25,42,83]. Circulating AGEs have been shown to correlate with as C-Reactive Protein (CRP) and other oxidative stress markers [42,83,84] and induce tissue injury [83,85]. In humans, dietary AGE restriction reduced plasma levels of CRP, Tumor Necrosis Factor-α (TNF-α), and vascular cell adhesion molecule-1 [84,86].…”