Dietary Alaska pollack protein improves skeletal muscle weight recovery after immobilization-induced atrophy in rats

Fujitani, Mina; Maekawa, Takafumi; Kawabata, Fuminori; Uozumi, Keisuke; Yasui, Machi; Hayamizu, Kohsuke; Uchida, Kenji; Okada, Shinji; Bhattarai, Keshab; Kishida, Taro

doi:10.1371/journal.pone.0217917

Cited by 8 publications

(8 citation statements)

References 28 publications

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“…Muscle regeneration and hypertrophy are modulated by the mitotic and myogenic activity of locally produced IGF-1, which functions in an autocrine/paracrine mode. We have previously reported that APP increased the expression of Igf1 genes in the immobilized limbs after the recovery period in the soleus muscle [ 14 ]. In this study, increased gene expression of Igf1 was not observed after 2, 7, and 56 days of feeding in rats fed a normal diet ( Table 4 , Table 5 and Table 6 ) in the gastrocnemius muscle.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, we used the AIN-93G diets based on casein as control. After immobilization, dietary APP intake enhanced skeletal muscle mass, not only in immobilized limbs but also in non-immobilized limbs after 21 days of feeding in rats fed a high-fat diet [ 14 ]. Certain food components have been reported to prevent obesity-related skeletal muscle atrophy [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, hypertrophy of intermuscular tissue also occurs with muscle hypertrophy, adapted to exercise [ 28 , 29 ]. Our previous study showed that dietary APP significantly increased the gene expression of Igf1 , Myog and Slc2a4 [ 11 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Alaska Pollack Protein Induces Acute and Sustainable Skeletal Muscle Hypertrophy in Rats

et al. 2022

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Our previous studies suggested that Alaska pollack protein (APP) intake increases skeletal muscle mass and that it may cause a slow-to-fast shift in muscle fiber type in rats fed a high-fat diet after 56 days of feeding. In this study, we explored whether dietary APP induces acute and sustainable skeletal muscle hypertrophy in rats fed a normal-fat diet. Male 5-week-old Sprague–Dawley rats were divided into four groups and fed a purified ingredient-based high-fat diet or a purified ingredient-based normal-fat diet with casein or APP, containing the same amount of crude protein. Dietary APP significantly increased gastrocnemius muscle mass (105~110%) after 2, 7 days of feeding, regardless of dietary fat content. Rats were separated into two groups and fed a normal-fat diet with casein or APP. Dietary APP significantly increased gastrocnemius muscle mass (110%) after 56 days of feeding. Dietary APP significantly increased the cross-sectional area of the gastrocnemius skeletal muscle and collagen-rich connective tissue after 7 days of feeding. It decreased the gene expression of Mstn /Myostatin, Trim63/MuRF1, and Fbxo32/atrogin-1, but not other gene expression, such as serum IGF-1 after 7 days of feeding. No differences were observed between casein and APP groups with respect to the percentage of Type I, Type IIA, and Type IIX or IIB fibers, as determined by myosin ATPase staining after 7 days of feeding. In the similar experiment, the puromycin-labeled peptides were not different between dietary casein and APP after 2 days of feeding. These results demonstrate that APP induces acute and sustainable skeletal muscle hypertrophy in rats, regardless of dietary fat content. Dietary APP, as a daily protein source, may be an approach for maintaining or increasing muscle mass.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dietary Alaska Pollack Protein Induces Acute and Sustainable Skeletal Muscle Hypertrophy in Rats

et al. 2022

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“…APP's biological activities including skeletal muscle hypertrophy (Mizushige et al, 2010;Kawabata et al, 2015;Watanabe et al, 2018Watanabe et al, , 2020Watanabe et al, , 2021Fujitani et al, 2019;Morisasa et al, 2019Morisasa et al, , 2022Uchida et al, 2022), anti-obesity (Oishi & Dohmoto, 2009;Mizushige et al, 2017;Maedaa et al, 2020), gut microbiota composition regulation (Hosomi et al, 2020;Maedaa et al, 2020;Tanaka et al, 2022), anti-cholesterol (Shukla et al, 2006;Hosomi et al, 2009Hosomi et al, , 2010Hosomi et al, , 2011Kato et al, 2011;Maedaa et al, 2020), blood glucose lowering (Oishi & Dohmoto, 2009;Kawabata et al, 2015;Hosomi et al, 2020) and non-alcoholic fatty liver disease (NAFLD; Shukla et al, 2006;Hosomi et al, 2009;Maedaa et al, 2020) have been reported. Although research on APP's biological activities have been conducted, there are no systematic reviews as per our knowledge.…”

Section: Introductionmentioning

confidence: 99%

“…Alaska pollock is claimed owning high protein, which is advantageous for health. To date, Alaska pollock proteins (APP) have been discovered to have biological activities in animal and humans (Mizushige et al, 2010;Fujitani et al, 2019;Watanabe et al, 2020Watanabe et al, , 2021Morisasa et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Alaska pollock (Gadus chalcogrammus) proteins and hydrolysed polypeptides: a systematic review of their potential bioactivities

Negara

Bashir²,

Park

et al. 2023

Int J of Food Sci Tech

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Summary Alaska pollock (Gadus chalcogrammus) is a marine fish that lives in the North Pacific Ocean. G. chalcogrammus contains high nutritional value, especially protein. Alaska pollock proteins (APP) and its peptides have been reported to have biological activities. However, the biological activities of APP have not been reviewed so far. The aim of this study was to review the published research on APP and its peptides, as well as their potential biological activities, using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. We used ScienceDirect, PubMed and Web of Science to identify the relevant references. In total, 43 studies were obtained and reviewed after the filtering process. Most of the research has focused on APP's prospective biological activities. The current study revealed that APP possesses biological activities, including skeletal muscle hypertrophy, anti‐obesity, anti‐cholesterol, blood glucose‐lowering and anti‐non‐alcoholic fatty liver effects. Peptides that are hydrolysed from APP possess biological activities, such as ACE inhibition, antioxidant effects, immunomodulation, anti‐diabetic, mineral chelation and wound healing activities. Only a few clinical studies were available on either APP or the respective peptides. Therefore, further study is needed to completely understand the potential of APP and the associated peptides as novel nutraceutical and functional food, as well as to evaluate their effects in humans.

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Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation

Symons¹,

Park²,

Kim³

et al. 2023

Integrative Medicine Research

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Dietary Alaska pollack protein improves skeletal muscle weight recovery after immobilization-induced atrophy in rats

Cited by 8 publications

References 28 publications

Dietary Alaska Pollack Protein Induces Acute and Sustainable Skeletal Muscle Hypertrophy in Rats

Dietary Alaska Pollack Protein Induces Acute and Sustainable Skeletal Muscle Hypertrophy in Rats

Alaska pollock (Gadus chalcogrammus) proteins and hydrolysed polypeptides: a systematic review of their potential bioactivities

Attenuation of skeletal muscle atrophy via acupuncture, electro-acupuncture, and electrical stimulation

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