Dietary Anthocyanins

Fernandes, Iva; Oliveira, Hélder; Marques, Cláudia; Faria, Ana; Calhau, Conceição; Mateus, Nuno; Freitas, Víctor de

doi:10.1002/9781119563754.ch7

Cited by 2 publications

(1 citation statement)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The phenomenon discovered was probably due to the type and number of substituents as well as the molecule size of the studied Cy derivatives. Considering the above findings and the fact that apart from the native compounds and phase II metabolites, there are also very important low-molecular-weight phenolic derivatives of anthocyanins formed mainly by the action of microflora, further investigation should be undertaken to characterize the ability of these anthocyanin metabolites (e.g., protocatechuic acid) to cross the BCSF barrier.…”

Section: Resultsmentioning

confidence: 99%

The Blood–Cerebrospinal Fluid Barrier Features Different Permeability to Cyanidin-3-galactoside and Cyanidin-3-diglucoside-5-glucoside and Their Metabolites Circulating in Blood

Płatosz

Bączek

Topolska

et al. 2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Previous studies have demonstrated the penetration of anthocyanins through the blood−cerebrospinal fluid barrier (BCSF barrier) after intraruminal administration of chokeberry and red cabbage preparation to sheep. However, they have failed to explain which food anthocyanin forms are more capable of crossing the BCSF barrier. Thus, this study aim was to verify the ability of cyanidin 3-galactoside (Cy3gal, main chokeberry anthocyanin) and cyanidin 3-diglucoside-5-glucoside (Cy3diG5G, main red cabbage anthocyanin) to cross the BCSF barrier on the sheep model (n = 16) after intravenous administration (to exclude the influence of gastrointestinal processes) of preparations containing these compounds. The micro-HPLC-MS/MS analysis showed that, after intravenous administration, anthocyanins penetrated the BCSF barrier and that the penetration potential of Cy3gal derivatives (6.73%) was higher than that of Cy3diG5G derivatives (6.10%), suggesting the observed differences to be largely due to the type and number of substituents as well as the size of the molecule.

show abstract

Section: Resultsmentioning

confidence: 99%