Dietary Antioxidant Capacity Indices are Negatively Correlated to LDL-Oxidation in Adults

Abstract

Introduction. Former research studies have demonstrated controversial associations between dietary indices and oxidative stress biomarkers including oxidized low-density lipoprotein (ox-LDL) and malondialdehyde (MDA). So, in this cross-sectional study, we aimed to assess the association of dietary total antioxidant capacity (DTAC), oxidative balance score, and phytochemical index (PI) with ox-LDL/MDA in a healthy adult population of Shiraz, Iran. Methods. 236 individuals participated in this cross-sectional study. DTAC, OBS, and PI were calculated using a 168-item food frequency questionnaire (FFQ), which was previously validated in Iran. We measured ox-LDL and MDA in blood samples of the participants using commercially existing kits. Crude and adjusted models of linear regression were used to evaluate the relation of dietary indices with ox-LDL and MDA. Results. There was a significant association between ox-LDL and DTAC in both crude (β = −1.55; 95% CI: −2.53, −0.58; P-trend = 0.002) and adjusted (β = −1.65 95% CI: −2.66, −0.64; P-trend = 0.001) models. Also, a negative association was observed between ox-LDL and PI in the crude (β = −1.26 95% CI: −2.33, −0.29; P-trend = 0.01) and adjusted (β = −1.36 95% CI: −2.38, −0.34; P-trend = 0.01) models. Conclusion. Results of this study showed that DTAC and PI were inversely associated with ox-LDL as markers of lipid peroxidation. But no correlations were seen between MDA and dietary antioxidant indices.

Oxidative balance score and dietary phytochemical index can reduce the risk of colorectal cancer in Iranian population

“…Based on a method by Goodman et al [ 27 ], the OBS was determined by collecting data from four classes: dietary pro-oxidants like saturated fatty acids (SFAs) [ 25 , 25 ], polyunsaturated fatty acids (PUFAs), and iron; non-dietary pro-oxidants such as smoking and obesity; non-dietary anti-oxidant such as physical activity; and dietary anti-oxidants for example fiber, vitamin C, vitamin B 9 , vitamin E, selenium, zinc, and beta-carotene [ 6 , 8 , 28 – 30 ]. Every score of these 13 components was summed, and the range of total score was between 0–26 (Table 1 ).…”

Effect of antioxidant-rich kindergarten meals on oxidative stress biomarkers in healthy 5–6-year-old children: a randomized controlled trial

“…In addition, it is associated with many beneficial effects on children’s health related to maintaining telomere length [ 14 ], obesity [ 15 , 16 ], allergic diseases [ 17 ], and lung function [ 18 ]. Consumption of dietary antioxidants can augment cellular redox balance [ 6 ] as they activate antioxidant signaling, improve endogenous antioxidant status, and suppress oxidative stress [ 19 ]. To assess the antioxidant capacity of the whole diet, the concept of dietary total antioxidant capacity (dTAC) was introduced, which is also a suitable indicator of dietary antioxidant properties [ 20 ].…”