Dietary apigenin regulates high glucose and hypoxic reoxygenation-induced reductions in apelin expression in human endothelial cells

Yamagata, Kazuo; Tagawa, Chika; Matsufuji, Hiroshi; Chino, Makoto

doi:10.1016/j.jnutbio.2011.04.019

Cited by 15 publications

(8 citation statements)

References 48 publications

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“…AP is also activating the intracellular PPARc receptor and can be useful to find out the way for metabolic disorders. It is reported that AP exhibits neuroprotection against oxidative stress-induced cell death by blocking caspase-3 activity [68]. Mascaraque et al [28] reported that AP has strong anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

2015

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Apigenin (AP) is a flavone in dietary flavonoids reported as strong antioxidant and elite modulator of PPARγ. The current study evaluated the consequence of AP in isoproterenol (ISO)-induced oxidative stress and myocardial infarction during β-adrenergic receptor stimulus in rats by persistent hemodynamic, biochemical and histopathological changes. Rats received AP (25, 50 and 75 mg/kg/day) or vehicle i.p. for 14 days and ISO (100 mg/kg, s.c.) on 13th and 14th days for initiation of cardiotoxicity. ISO-treated rats showed evidence of significant dwindle in systolic and diastolic arterial pressures, maximal positive rate of developed left ventricular pressure. In totting up, a noteworthy diminution in activities of creatine kinase-MB isoenzyme, reduced glutathione, superoxide dismutase, catalase and level along with rise in malondialdehyde content were observed. The shielding function of AP on isoproterenol-induced myocardial damage was observed by attenuating all the endogenous parameters and the membrane-bound enzymes. It was confirmed by histopathological examinations. The effect of AP at the doses of 50 and 75 mg/kg showed added apparent than at the dose of 25 mg/kg. Current study thus provides confirmation for protective effects of AP on myocardium in experimentally induced myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

2015

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“…This is in line with our previous demonstration that luminal secretion of gut leptin was observed without any modification of blood leptin levels in rat 13 .Eventhough apelin and glucose have been tightly associated in several studies, the direct effect of glucose on a putative apelin secretion has been poorly described. Yamagata et al have recently shown that human endothelial cultured cells secrete apelin in response to glucose andRingstrom et al describeda slight increase of mRNA apelin in isolated human pancreatic islets after glucose stimulation 15,28 . In our study, although concentrations of glucose used ex vivo(30 mmol/L) are physiologically relevant and comparable to other studies 12,13 , in vivoexperiments required higher doses of glucose (up to 100mg/100l) to ensure that a significant amount of glucose reaches small intestine few minutes after oral load.…”

Section: Discussionmentioning

confidence: 99%

The Intestinal Glucose–Apelin Cycle Controls Carbohydrate Absorption in Mice

et al. 2013

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Glucose amplifies its own transport from the intestinal lumen to the bloodstream by increasing luminal apelin secretion. In the lumen, active apelin regulates carbohydrate flux through enterocytes by promoting AMPKα2 phosphorylation and modifying the ratio of SGLT-1:GLUT2. The glucose-apelin cycle might be pharmacologically handled to regulate glucose absorption and assess better control of glucose homeostasis.

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“…For example, luteolin has been found to possess antioxidant [5], anticancer action [6], anti-inflammatory [7], antihepatotoxic action [8], antiallergic, antiosteoporotic [9], antidiabetic [10], and antiplatelet and vasodilatory activity [11]. In addition to antioxidant, anticancer, and anti-inflammatory, apigenin also exhibits antihyperglycemic action [12] and antinociceptive effect [13]. Luteolin and apigenin are natural food additives used extensively in the food and pharmaceutical industries.…”

Section: Introductionmentioning

confidence: 99%

Microwave-Assisted Simultaneous Extraction of Luteolin and Apigenin from Tree Peony Pod and Evaluation of Its Antioxidant Activity

Wang

Yang

et al. 2014

The Scientific World Journal

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An efficient microwave-assisted extraction (MAE) technique was employed in simultaneous extraction of luteolin and apigenin from tree peony pod. The MAE procedure was optimized using response surface methodology (RSM) and compared with other conventional extraction techniques of macerate extraction (ME) and heat reflux extraction (HRE). The optimal conditions of MAE were as follows: employing 70% ethanol volume fraction as solvent, soaking time of 4 h, liquid-solid ratio of 10 (mL/g), microwave irradiation power of 265 W, microwave irradiation time of 9.6 min, and 3 extraction cycles. Under the optimal conditions, 151 μg/g luteolin and 104 μg/g apigenin were extracted from the tree peony pod. Compared with ME and HRE, MAE gave the highest extraction efficiency. The antioxidant activities of the extracts obtained by MAE, ME, and HRE were evaluated using a 2,2-di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH) free radical-scavenging assay, a ferric reducing antioxidant power assay (FRAP), and a reducing power assay. Meanwhile, the structural changes of the unprocessed and processed tree peony pod samples were analyzed by scanning electron microscopy.

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Dietary apigenin regulates high glucose and hypoxic reoxygenation-induced reductions in apelin expression in human endothelial cells

Cited by 15 publications

References 48 publications

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

Apigenin Attenuates β-Receptor-Stimulated Myocardial Injury Via Safeguarding Cardiac Functions and Escalation of Antioxidant Defence System

The Intestinal Glucose–Apelin Cycle Controls Carbohydrate Absorption in Mice

Microwave-Assisted Simultaneous Extraction of Luteolin and Apigenin from Tree Peony Pod and Evaluation of Its Antioxidant Activity

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