Dietary Berries and Ellagic Acid Diminish Estrogen-Mediated Mammary Tumorigenesis &amp;isin; ACI rats

Aiyer, Harini S.; Srinivasan, Cidambi; Gupta, Ramesh C.

doi:10.1080/01635580701624712

Cited by 91 publications

(109 citation statements)

References 46 publications

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“…This study also demonstrated that the anthocyanin fraction of black raspberries (BRB) was as effective in preventing chemically-induced esophageal tumors in rats as whole BRB powder [6]. Our own studies have shown significant inhibition of breast cancer in the rat model by both blueberry (BB) and BRB, indicating that berries are chemopreventive beyond the GI tract [7][8][9]. Our studies with BB diet have also shown that berry anthocyanidins are bioavailable beyond the GI as we could detect all anthocyanidins in lung tissues [10].…”

Section: Introductionmentioning

confidence: 77%

Lung cancer inhibitory activity of dietary berries and berry polyphenolics

Aqil

Jeyabalan

Kausar

et al. 2016

JBR

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Abstract.BACKGROUND: Blueberry (BB) and black raspberry (BRB) have been shown to be chemopreventive against estrogenmediated breast cancer in pre-clinical studies. However, therapeutic efficacy of these berries against lung cancer is not known. METHODS: In this study we investigated i) relative efficacy of individual anthocyanidins vs. respective anthocyanins, ii) relative antiproliferative activity of mixture of anthocyanidins compared to individual anthocyanidins, iii) antitumor activity of dietary BB, iv) Tumor inhibitory activity of diet supplemented with BB, alone and in combination with BRB, against lung tumor xenograft using nude mice, and finally, v) the efficacy of select polyphenolics present in BB and BRB against lung tumor xenograft. RESULTS: Our findings indicated that individual anthocyanidins (aglycones) were significantly more potent (2-3 fold lower IC 50 ) in inhibiting the non-small-cell lung cancer (NSCLC) cell growth vs. respective anthocyanins (glycones). Further, anthocyanidins mixture at equimolar concentrations exhibited synergistic antiproliferative activity vs. individual anthocyanidins. When tested against NSCLC (A549 and H1299) cells in nude mice, dietary BB (7.5%, w/w) showed >40% reduction in tumor volume against H1299 xenografts. The maximal growth inhibition occurred with 5% BB dose, with no additional protection occurring at a higher dose (7.5%). However, somewhat lower protection was found when the BB diet initiated prior to tumor cell inoculation. The mixture of BB (5%, w/w) and BRB (2.5%) resulted in higher inhibition of tumor growth vs. BB alone (71% vs 42%). Likewise, a combination of delphinidin (bioactive of BB) and punicalagins (a bioactive of BRB, which gets converted to ellagic acid in vivo) showed higher tumor growth inhibition compared to delphinidin. CONCLUSIONS: The therapeutic effects of the berries and berry polyphenolics observed against lung cancer in this study are highly encouraging. Further investigation into the mechanism of action of the combinations of the berry bioactives will be valuable for clinical use of this potent natural product against lung cancer.

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Section: Introductionmentioning

confidence: 77%

Lung cancer inhibitory activity of dietary berries and berry polyphenolics

Aqil

Jeyabalan

Kausar

et al. 2016

JBR

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“…Ellagic acid. Ellagic acid, a component in berries (blueberry, strawberry, and red raspberry), was reported to reduce oxidative DNA damage both in vitro and in vivo (4,5). In vitro, ellagic acid has demonstrated a >95% inhibition of 8-oxodeoxyguosine (8-oxodG) production.…”

Section: A Dietary Antioxidantsmentioning

confidence: 99%

Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development

Luo

Kelley

et al. 2010

Antioxidants & Redox Signaling

113

136

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Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair. Antioxid. Redox Signal. 12, 1247-1269.

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“…[22][23][24][25][26][27][28][29] These data demonstrated that pomegranate phytochemicals provide protection against various cancer-related processes.…”

mentioning

confidence: 82%

Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention

Shirode¹,

Bharali²,

Nallanthighal³

et al. 2015

IJN

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Pomegranate polyphenols are potent antioxidants and chemopreventive agents but have low bioavailability and a short half-life. For example, punicalagin (PU), the major polyphenol in pomegranates, is not absorbed in its intact form but is hydrolyzed to ellagic acid (EA) moieties and rapidly metabolized into short-lived metabolites of EA. We hypothesized that encapsulation of pomegranate polyphenols into biodegradable sustained release nanoparticles (NPs) may circumvent these limitations. We describe here the development, characterization, and bioactivity assessment of novel formulations of poly(D,L-lactic- co -glycolic acid)–poly(ethylene glycol) (PLGA–PEG) NPs loaded with pomegranate extract (PE) or individual polyphenols such as PU or EA. Monodispersed, spherical 150–200 nm average diameter NPs were prepared by the double emulsion–solvent evaporation method. Uptake of Alexa Fluor-488-labeled NPs was evaluated in MCF-7 breast cancer cells over a 24-hour time course. Confocal fluorescent microscopy revealed that PLGA–PEG NPs were efficiently taken up, and the uptake reached the maximum at 24 hours. In addition, we examined the antiproliferative effects of PE-, PU-, and/or EA-loaded NPs in MCF-7 and Hs578T breast cancer cells. We found that PE, PU, and EA nanoprototypes had a 2- to 12-fold enhanced effect on cell growth inhibition compared to their free counterparts, while void NPs did not affect cell growth. PU-NPs were the most potent nanoprototype of pomegranates. Thus, PU may be the polyphenol of choice for further chemoprevention studies with pomegranate nanoprototypes. These data demonstrate that nanotechnology-enabled delivery of pomegranate polyphenols enhances their anticancer effects in breast cancer cells. Thus, pomegranate polyphenols are promising agents for nanochemoprevention of breast cancer.

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Dietary Berries and Ellagic Acid Diminish Estrogen-Mediated Mammary Tumorigenesis ∈ ACI rats

Cited by 91 publications

References 46 publications

Lung cancer inhibitory activity of dietary berries and berry polyphenolics

Lung cancer inhibitory activity of dietary berries and berry polyphenolics

Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development

Nanoencapsulation of pomegranate bioactive compounds for breast cancer chemoprevention

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