Dietary betaine supplementation improves growth performance, digestive function, intestinal integrity, immunity, and antioxidant capacity of yellow-feathered broilers

Song, Yuduo; Chen, Rui; Yang, Ming; Liu, Qiang; Zhou, Yanmin; Zhuang, Songlin

doi:10.1080/1828051x.2021.1986681

Cited by 12 publications

(4 citation statements)

References 48 publications

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“…Additionally, it was reported that dietary betaine supplementation in broiler chicks improved the epithelial villus–crypt ratio in the broiler's gut, and the improved mucosal microstructure (Sun et al, 2019). In the same way, Song et al (2021) declared that dietary inclusion with the optimal dosage of betaine (1000 mg/kg) improved the digestive process, and gut mucosal barrier integrity of broilers. This effect may be due to both the methyl group donor activities and the osmolyte functions of betaine (Kettunen et al, 2001).…”

Section: Discussionmentioning

confidence: 90%

Effect of in‐ovo inoculation of betaine on hatchability, serum antioxidant levels, muscle gene expression and intestinal development of broiler chicks

El‐Shater,

Abo‐EL‐Sooud,

Tolba

et al. 2024

Animal Physiology Nutrition

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This study investigated the effects of in‐ovo inoculation of betaine on hatchability, hatching weight, and intestinal development, as well as serum and expression levels of some antioxidants in the posthatched chicks. A total of 350 fertile eggs of Hubbard efficiency plus breeder's flock were incubated at normal incubation temperature (37.5°C) and randomly assembled into 3 groups with 4 replicates, and 25 eggs per each. The experimental groups were allocated as noninjected control group (CN), diluent‐injected group (CP, 0.1 mL saline), and betaine‐injected group (B, 2.5 mg in 0.1 mL saline). The injections were performed in the air cells of the eggs on the 12th day of the embryonic phase. Hatchability percentage, hatching weight, serum‐reduced glutathione (GSH), and superoxide dismutase (SOD) were estimated in 7‐day‐old chicks. Moreover, expression levels of the nuclear factor erythroid 2–related factor 2 (Nrf2) and SOD were determined in the breast skeletal muscles of chicks. Jejunum histo‐morphometric analysis was assessed with computerised morphometric measurements. The results revealed that the hatchability percentage was not influenced by in‐ovo injection of betaine or vehicle while betaine significantly increased the hatchling's weight of chicks. Moreover, there were a significant increase in SOD and Nrf2 mRNA expression levels. In‐ovo injection of betaine significantly induced positive effects on intestinal morphometry by ameliorating the jejunal villus length, the ratio of villus height to villus width, and absorptive surface area.

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Section: Discussionmentioning

confidence: 90%

Effect of in‐ovo inoculation of betaine on hatchability, serum antioxidant levels, muscle gene expression and intestinal development of broiler chicks

El‐Shater,

Abo‐EL‐Sooud,

Tolba

et al. 2024

Animal Physiology Nutrition

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“…The intestinal mucosal immune system relies on TLRs to transmit signals and mediates the proinflammatory effect ( Chow et al, 1999 ; Vallabhapurapu and Karin, 2009 ). The TLR4, NF-kβ, and IL-1β mRNA expression in broilers’ intestines were reduced by BT treatment ( Song et al, 2021 ). In addition, the NF-kβ pathway was inhibited or downregulated by BT to alleviate stress in rats ( Yang et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary supplementation of betaine and organic minerals on growth performance, serum biochemical parameters, nutrients digestibility, and growth-related genes in broilers under heat stress

Saleh,

El-Tahan,

Shaban

et al. 2023

Poultry Science

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“…The sIgA is the main antibody of intestinal mucosal immunity and plays an important role in the clearance of pathogens and harmful substances, maintenance of intestinal environmental homeostasis and intestinal mucosal immunity. TNF-α is mainly produced by macrophages and monocytes, has proin ammatory properties and plays an important role in apoptosis, cell proliferation and immune response [41]. Il-4, as an anti-in ammatory factor, has a role in downregulating in ammatory response and antagonising in ammatory mediators [42].…”

Section: Discussionmentioning

confidence: 99%

Betaine addition to dietary can alleviate intestinal injury to growing meat rabbits in summer heat through the AAT/mTOR pathway

Li,

Pu,

Chen

et al. 2023

Preprint

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Background The aim of this experiment was to investigate the effect of different levels of betaine (Bet) inclusion in the diet on the intestinal health of growing meat rabbits under summer heat. A total of 100 weaned Qixing meat rabbits aged 35 days with similar body weight (748.61 ± 38.59 g) were randomly divided into five treatment groups: control group (basal diet), and Bet groups (basal diet + 0.75, 1.0, 1.5 or 2.0 g/kg Bet). The average daily temperature in the rabbitry during the experiment was 30.48°C and the relative humidity was 69.44%. Results Dietary addition of Bet had no significant effect on growth performance and health status of growing meat rabbits (P > 0.05), but it increased ileal secretory immunoglobulin A (sIgA) content compared to the control under summer heat (P < 0.05). Addition of 0.75 g/kg Bet up-regulated jejunal IL-4, down-regulated ileal TNF-α expression (P < 0.05). The addition of 1.0 g/kg Bet increased the villi height (VH) in the jejunum (P < 0.05). Serum glucose levels were reduced in rabbits, and up-regulated jejunal and ileal SLC6A20 expression fed with 1.5 g/kg Bet (P < 0.05). When added at 2.0 g/kg, Bet reduced serum HSP70 content, jejunal VH was increased, and up-regulated duodenal SLC7A6, SLC38A2, mTOR and 4EBP-2 expression (P < 0.05). Correlation analysis revealed that intestinal mTOR expression was significantly and positively correlated with SLC7A6, SLC38A2, SLC36A1 and IL-4 expression (P < 0.05). Conclusions Dietary addition of Bet can up-regulate the expression of anti-inflammatory factors through the AAT/mTOR pathway, improve the intestinal immune function, alleviate intestinal damage in growing meat rabbits caused by summer heat, and improve intestinal health, with the best results achieved when the amount of Bet was 2.0 g/kg.

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Dietary betaine supplementation improves growth performance, digestive function, intestinal integrity, immunity, and antioxidant capacity of yellow-feathered broilers

Cited by 12 publications

References 48 publications

Effect of in‐ovo inoculation of betaine on hatchability, serum antioxidant levels, muscle gene expression and intestinal development of broiler chicks

Effect of in‐ovo inoculation of betaine on hatchability, serum antioxidant levels, muscle gene expression and intestinal development of broiler chicks

Effect of dietary supplementation of betaine and organic minerals on growth performance, serum biochemical parameters, nutrients digestibility, and growth-related genes in broilers under heat stress

Betaine addition to dietary can alleviate intestinal injury to growing meat rabbits in summer heat through the AAT/mTOR pathway

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