Dietary caffeic acid, ferulic acid and coumaric acid supplements on cholesterol metabolism and antioxidant activity in rats

Yeh, Yen-Hung; Lee, Ya-Ting; Hsieh, Hung-Sheng; Hwang, Deng‐Fwu

doi:10.38212/2224-6614.2292

Cited by 15 publications

(14 citation statements)

References 47 publications

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“…Reductions in some components of the lipid composition of the blood (such as triglycerides and VLDL) of lambs could be explained by inhibition of the synthesis of cholesterol in the liver by flavonoids and phenolic acids [49][50][51]; however, in our study, inhibition occurred only for VLDL and did not change LDL.…”

Section: Health Parametersmentioning

confidence: 58%

Inclusion of Yerba Mate (Ilex paraguariensis) Extract in the Diet of Growing Lambs: Effects on Blood Parameters, Animal Performance, and Carcass Traits

Lobo

Vincenzi

Moreno

et al. 2020

Animals

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This study aimed to evaluate levels of yerba mate (Ilex paraguariensis) extract (YME), as a feed additive in the diets of growing lambs on serum biochemical parameters and hematological indices, animal performance, body metrics and carcass traits. Thirty-six entire (nine per treatment), male growing lambs, weighing 23.8 ± 3.7 kg, were fed the experimental diets which were treatments consisting of increasing levels of YME (0, 1, 2, and 4% inclusion on a dry matter [DM] basis) during an experimental period of 53 days. The experiment was carried out in a randomized block design, which initial body weight was used as blocking factor and the results were analyzed by orthogonal contrasts (linear, quadratic, and cubic). Yerba mate extract did not change the general health status of the animals; however, inclusions of up to 2% of the extract increased globulins (p = 0.05) and white blood cell count, as segmented neutrophils (p = 0.02) and lymphocytes (p = 0.04). Additionally, inclusion of up to 2% YME increased dry matter intake, final weight gain, total and daily gain (p < 0.05), also tended to increase ribeye area and reduce fat thickness (p < 0.10); however, YME above 2% of inclusion reduced animal productive parameters (p < 0.05). In conclusion, levels up to 2% of YME were beneficial to the health and productive parameters of growing lambs.

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Section: Health Parametersmentioning

confidence: 58%

Inclusion of Yerba Mate (Ilex paraguariensis) Extract in the Diet of Growing Lambs: Effects on Blood Parameters, Animal Performance, and Carcass Traits

Lobo

Vincenzi

Moreno

et al. 2020

Animals

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“…Our data demonstrated that ferulic acid supplementation can decrease levels of TC, LDL-C, and TG. Similarly, previous studies have reported that ferulic acid improves lipid levels in vitro; and the outcome of animal studies indicate that the probable mechanism of action is via inhibition of HMG-Co A reductase, which controls cholesterol synthesis and modulates the expression of lipogenic genes in the liver [ 14 , 17 , 18 , 27 ]. The mechanism by which ferulic acid increases HDL-C levels remains unclear.…”

Section: Discussionmentioning

confidence: 68%

“…Furthermore, ferulic acid can exert an anti-oxidant effect which is beneficial for cancer prevention by quenching reactive oxygen species (ROS), thereby inducing apoptosis and proliferative reduction [ 13 , 15 , 16 ]. Moreover, ferulic acid could reduce the level of HMG-CoA reductase, the key enzyme of cholesterol synthesis [ 14 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

et al. 2018

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Ferulic acid is the most abundant phenolic compound found in vegetables and cereal grains. In vitro and animal studies have shown ferulic acid has anti-hyperlipidemic, anti-oxidative, and anti-inflammatory effects. The objective of this study is to investigate the effects of ferulic acid supplementation on lipid profiles, oxidative stress, and inflammatory status in hyperlipidemia. The study design is a randomized, double-blind, placebo-controlled trial. Subjects with hyperlipidemia were randomly divided into two groups. The treatment group (n = 24) was given ferulic acid (1000 mg daily) and the control group (n = 24) was provided with a placebo for six weeks. Lipid profiles, biomarkers of oxidative stress and inflammation were assessed before and after the intervention. Ferulic acid supplementation demonstrated a statistically significant decrease in total cholesterol (8.1%; p = 0.001), LDL-C (9.3%; p < 0.001), triglyceride (12.1%; p = 0.049), and increased HDL-C (4.3%; p = 0.045) compared with the placebo. Ferulic acid also significantly decreased the oxidative stress biomarker, MDA (24.5%; p < 0.001). Moreover, oxidized LDL-C was significantly decreased in the ferulic acid group (7.1%; p = 0.002) compared with the placebo group. In addition, ferulic acid supplementation demonstrated a statistically significant reduction in the inflammatory markers hs-CRP (32.66%; p < 0.001) and TNF-α (13.06%; p < 0.001). These data indicate ferulic acid supplementation can improve lipid profiles and oxidative stress, oxidized LDL-C, and inflammation in hyperlipidemic subjects. Therefore, ferulic acid has the potential to reduce cardiovascular disease risk factors.

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“…This postulation is further supported by a number of studies reporting on the in vivo antioxidant properties of major phenolic compounds detected in DKSM and PSRE, that is, p -coumaric acid, caffeic acid, (+)-catechin, and gallic acid. For instance, oral administration of p -coumaric acid and gallic acid at the dosage of 100 mg/kg body weight for 2 weeks was found to greatly improve the cardiac and hepatic total antioxidant capacities of healthy rats [ 38 , 39 ], while dietary supplementation with caffeic and coumaric acids (0.2% of total diet) for 6 weeks effectively enhanced the in vivo antioxidant capacity of hypercholesterolemic rats [ 40 ]. On the other hand, plasma and urine TAC of Wistar rats was significantly increased following 10 days of intraperitoneal administration of catechin mixture (23 mg/kg body weight) [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Defatted Kenaf (Hibiscus cannabinus L.) Seed Meal and Its Phenolic‐Saponin‐Rich Extract Protect Hypercholesterolemic Rats against Oxidative Stress and Systemic Inflammation via Transcriptional Modulation of Hepatic Antioxidant Genes

Chan

Ismail

Norhaizan

et al. 2018

Oxidative Medicine and Cellular Longevity

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The present study aimed to investigate the antioxidant and anti-inflammatory properties of defatted kenaf seed meal (DKSM) and its phenolic-saponin-rich extract (PSRE) in hypercholesterolemic rats. Hypercholesterolemia was induced using atherogenic diet feeding, and dietary interventions were conducted by incorporating DKSM (15% and 30%) or PSRE (at 2.3% and 4.6%, resp., equivalent to the total content of DKSM-phenolics and saponins in the DKSM groups) into the atherogenic diets. After ten weeks of intervention, serum total antioxidant capacities of hypercholesterolemic rats were significantly enhanced by DKSM and PSRE supplementation (p < 0.05). Similarly, DKSM and PSRE supplementation upregulated the hepatic mRNA expression of antioxidant genes (Nrf2, Sod1, Sod2, Gsr, and Gpx1) of hypercholesterolemic rats (p < 0.05), except for Gpx1 in the DKSM groups. The levels of circulating oxidized LDL and proinflammatory biomarkers were also markedly suppressed by DKSM and PSRE supplementation (p < 0.05). In aggregate, DKSM and PSRE attenuated the hypercholesterolemia-associated oxidative stress and systemic inflammation in rats, potentially by enhancement of hepatic endogenous antioxidant defense via activation of the Nrf2-ARE pathway, which may be contributed by the rich content of phenolics and saponins in DKSM and PSRE. Hence, DKSM and PSRE are prospective functional food ingredients for the potential mitigation of atherogenic risks in hypercholesterolemic individuals.

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Dietary caffeic acid, ferulic acid and coumaric acid supplements on cholesterol metabolism and antioxidant activity in rats

Cited by 15 publications

References 47 publications

Inclusion of Yerba Mate (Ilex paraguariensis) Extract in the Diet of Growing Lambs: Effects on Blood Parameters, Animal Performance, and Carcass Traits

Inclusion of Yerba Mate (Ilex paraguariensis) Extract in the Diet of Growing Lambs: Effects on Blood Parameters, Animal Performance, and Carcass Traits

Ferulic Acid Supplementation Improves Lipid Profiles, Oxidative Stress, and Inflammatory Status in Hyperlipidemic Subjects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Defatted Kenaf (Hibiscus cannabinus L.) Seed Meal and Its Phenolic‐Saponin‐Rich Extract Protect Hypercholesterolemic Rats against Oxidative Stress and Systemic Inflammation via Transcriptional Modulation of Hepatic Antioxidant Genes

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