Dietary carotenoid pigment supplementation influences hepatic lipid and mucopolysaccharide levels in rainbow trout (Oncorhynchus mykiss)

Page, G.I.; Russell, Paul; Davies, Steffan

doi:10.1016/j.cbpb.2005.09.001

Cited by 19 publications

(12 citation statements)

References 28 publications

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“…Regarding liver, feeding red porgy for 120 days before harvest on ASTX diet not only diminished the total lipid content but also palmitic acid, which is an important fish energy source. In a study with rainbow trout, both dietary astaxanthin and canthaxanthin had a significant impact on liver total lipid profiles (Page et al 2005); nevertheless, in contrast to our results, higher lipid levels were reported when rainbow trout were fed a carotenoid-supplemented diet. In obese mice, fed on high fat diets, astaxanthin seems to stimulate lipid utilization as an energy source, reducing body weight, weight of adipose tissue, liver weight and liver triglyceride (Ikeuchi et al 2007).…”

Section: Discussioncontrasting

confidence: 85%

“…In Atlantic salmon (Salmo salar), an alteration in oxidation potential due to dietary astaxanthin increased liver cellular synthesis of long chain PUFA (Bell et al 2000). In rainbow trout (Onchorhynchus mykiss), astaxanthin and canthaxanthin were found to modify liver total lipid profile, potentially due to their antioxidant function (Page et al 2005). In obese mice, astaxanthin reduced body weight, weight of adipose tissue, liver weight, liver triglyceride, plasma triglyceride and plasma total cholesterol (Ikeuchi et al 2007).…”

Section: Introductionmentioning

confidence: 97%

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Effect of dietary astaxanthin on the growth performance, lipid composition and post-mortem skin colouration of red porgy Pagrus pagrus

2010

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A 120-day feeding trial was conducted to assess the possible effect of including dietary astaxanthin (ASTX), for different lengths of time prior to harvest, on red porgy growth performance, lipid and fatty acid composition and post-mortem skin colour. Four treatment groups were established with fish of initial weight of approximately 220 g. Control group was fed on a control diet (with no astaxanthin included) for the entire experiment. ASTX60 group was fed for the first 60 days of the trial on the control diet and 60 days before harvest on a diet with 100 mg of unesterified astaxanthin per kg -1 of diet (ASTX diet). ASTX90 group was fed for the first 30 days of the trial on control diet and 90 days before harvest on ASTX diet. ASTX120 group was fed on ASTX diet during the complete experiment. Results showed an enhancement of certain growth parameters due to ASTX diet and feeding period. In addition, a lipid-lowering effect on whole fish and liver was observed with increased feeding time with ASTX diet, as well as a significant variation of liver and head kidney fatty acid profiles. Concerning skin colouration, only ASTX90 and ASTX120 treatment groups presented adequate hue values throughout the 7 days postmortem, similar to those reported for wild red porgy. However, skin chroma was close to wild specimens in ASTX120 treatment fish only and up to day three post-mortem. Skin lightness (L*) was not affected by astaxanthin inclusion. Feeding red porgy for a period of 90-120 days before harvest on ASTX diet seems to affect red porgy growth performance, lipid content and fatty acid profile. However, to achieve an adequate skin colouration, throughout a post-mortem period of 7 days, ASTX diet should be given 120 days before harvest.

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Section: Discussioncontrasting

confidence: 85%

Section: Introductionmentioning

confidence: 97%

Effect of dietary astaxanthin on the growth performance, lipid composition and post-mortem skin colouration of red porgy Pagrus pagrus

2010

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“…In this study, hypoxia stress had no e¡ect on ALT activity but increased ASTactivity by 254%. A recent study showed that CD treatment signi¢cantly altered the total lipid pro¢le and hepatic mucopolysaccharide contents of the livers of rainbow trout (Page, Russell & Davies 2005). However, both ALT and AST showed the same decreasing trend when the dietary CD concentration increased.…”

Section: Alt and Astmentioning

confidence: 98%

The antioxidant capacity response to hypoxia stress during transportation of characins (Hyphessobrycon callistusBoulenger) fed diets supplemented with carotenoids

Pan

Chien

Wang

2009

Aquaculture Research

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This study aimed to determine whether dietary carotenoid (CD) supplements could a¡ect the antioxidant capacity of characins Hyphessobrycon callistus upon hypoxia stress at live transportation. Two types of CD [astaxanthin (AX), b-carotene (BC)] and their 1:1 combination (MX) at three concentrations (10, 20 and 40 mg kg À 1 ) were supplemented, resulting in nine CD diets. After 8 weeks' rearing, the resulting ¢sh were divided into two subgroups and exposed to hypoxia or normoxia. Hypoxia involved a gradual decrease in dissolved oxygen (DO) from 6.5 to o1.0 mg L À 1 . Normoxia was DO kept in saturation.Hypoxia led to an increase in the total antioxidant status (TAS), superoxide dismutase (SOD), glutathione peroxidases (GPx) and aspartate aminotransferase (AST) activity of blood serum in ¢sh, but had no e¡ect on alanine aminotransferase (ALT). Under hypoxia, ¢sh fed CD diets had lower SOD, GPx and ALT activity than control ¢sh, showing that dietary CD could increase the antioxidant capacity and protection of the liver. Dietary AX was more e¡ective for antioxidant capacity than BC and MX when under hypoxia stress, because GPx, ALT and AST were lower in AX-fed ¢sh. Except TAS, the other four enzyme activities showed decreasing trends with increasing dietary CD concentrations.

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“…In crustaceans, dietary ATX improves survival and growth (6)(7)(8), as well as increases resistance to physical and chemical stressors (9)(10)(11)(12). In fish, dietary ATX alters liver function (13) and liver lipid profile (14), and it improves defenses against oxidative stress (15)(16)(17). Taken together, these data suggest that ATX is a protective agent in marine plants and fish.…”

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confidence: 89%

Astaxanthin reduces ischemic brain injury in adult rats

et al. 2009

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Astaxanthin (ATX) is a dietary carotenoid of crustaceans and fish that contributes to their coloration. Dietary ATX is important for development and survival of salmonids and crustaceans and has been shown to reduce cardiac ischemic injury in rodents. The purpose of this study was to examine whether ATX can protect against ischemic injury in the mammalian brain. Adult rats were injected intracerebroventricularly with ATX or vehicle prior to a 60-min middle cerebral artery occlusion (MCAo). ATX was present in the infarction area at 70-75 min after onset of MCAo. Treatment with ATX, compared to vehicle, increased locomotor activity in stroke rats and reduced cerebral infarction at 2 d after MCAo. To evaluate the protective mechanisms of ATX against stroke, brain tissues were assayed for free radical damage, apoptosis, and excitoxicity. ATX antagonized ischemia-mediated loss of aconitase activity and reduced glutamate release, lipid peroxidation, translocation of cytochrome c, and TUNEL labeling in the ischemic cortex. ATX did not alter physiological parameters, such as body temperature, brain temperature, cerebral blood flow, blood gases, blood pressure, and pH. Collectively, our data suggest that ATX can reduce ischemia-related injury in brain tissue through the inhibition of oxidative stress, reduction of glutamate release, and antiapoptosis. ATX may be clinically useful for patients vulnerable or prone to ischemic events.

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Dietary carotenoid pigment supplementation influences hepatic lipid and mucopolysaccharide levels in rainbow trout (Oncorhynchus mykiss)

Cited by 19 publications

References 28 publications

Effect of dietary astaxanthin on the growth performance, lipid composition and post-mortem skin colouration of red porgy Pagrus pagrus

Effect of dietary astaxanthin on the growth performance, lipid composition and post-mortem skin colouration of red porgy Pagrus pagrus

The antioxidant capacity response to hypoxia stress during transportation of characins (Hyphessobrycon callistusBoulenger) fed diets supplemented with carotenoids

Astaxanthin reduces ischemic brain injury in adult rats

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