Dietary catechin delays tumor onset in a transgenic mouse model

Abstract

Physiologic intakes of specific dietary polyphenols, such as catechin, may play an important role in cancer chemoprevention. Wines have different polyphenol concentrations and compositions; therefore, the overall health benefits of individual wines differ.

Apple phytochemicals and their health benefits

“…The procyanidins, epicatechin and catechin, have strong antioxidant activity and have been found to inhibit low density lipoprotein (LDL) oxidation in vitro [49]. In mice, catechin inhibits intestinal tumor formation and delays tumors onset [50,51]. Sawa et al (1999) found that chlorogenic acid has very high alkyl peroxyl radical (ROO•) scavenging activity.…”

Lipid nanocarriers based on natural oils with high activity against oxygen free radicals and tumor cell proliferation

“…e l s e v i e r . c o m / l o c a t e / m s e c rodent models [19]. An irreparable DNA damage leading to G2/M arrest and apoptosis selectively in head and neck squamous cell carcinoma was also reported by Shrotriya et al [20].…”

Estrogen and the Dietary Phytoestrogen Resveratrol as Regulators of the Rho GTPase Rac in Breast Cancer Research

“…Her-2 is often overexpressed in metastatic cancers including the MDA-MB-435 cell line that was used for this study. The monomeric form of catechin constitutes up to 65 70% of total red wine polyphenols and has been shown to delay tumor initiation [10,15,16]. Resveratrol, quercetin, and catechin are all viable chemopreventives because they are absorbed and metabolized rapidly in vivo and can be detected in plasma and urine samples in the intact form in humans and rodent models [17 20].…”

“…Resveratrol has proapoptotic, antigrowth, anti-inflammmatory, antiangiogenic, and anti-invasive properties that makes it an attractive anticancer compound (12)(13)(14). Much of the data on potential anticancer properties of resveratrol has been shown in vitro with high concentrations of resveratrol ranging from 30-200 µM (15)(16)(17)(18)(19)(20)(21). We and others have shown that resveratrol at 50 µM can inhibit cell migration and invasion (22)(23)(24)(25).…”