Dietary cellulose has no effect on the regeneration of hemoglobin in growing rats with iron deficiency anemia

Catani, Maria Valeria; Amâncio, Olga Maria Silvério; Fagundes-Neto, Ulysses; Morais, Mauro Batista de

doi:10.1590/s0100-879x2003000600002

Cited by 14 publications

(23 citation statements)

References 16 publications

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“…Indeed, the same research team observed, in an excellent previous experiment, significantly greater ingestion of the diet containing cellulose than of the diet without DF. 10 In addition, in that experiment 10 exactly double the quantity of DF (100 g of cellulose per kg of diet), than in the experiment by Freitas et al, 8 was offered, generating a much higher fecal weight (10.7 vs. 5.2 g). According to Catani et al, 10 50 g of cellulose corresponds to 12.5 g of fiber per 1,000 kcal, which would be the recommended intake for children.…”

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confidence: 78%

“…10 In addition, in that experiment 10 exactly double the quantity of DF (100 g of cellulose per kg of diet), than in the experiment by Freitas et al, 8 was offered, generating a much higher fecal weight (10.7 vs. 5.2 g). According to Catani et al, 10 50 g of cellulose corresponds to 12.5 g of fiber per 1,000 kcal, which would be the recommended intake for children. However, taking into account the fecal characteristics of rats, it could be asked whether the higher DF proportion would be desirable.…”

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Constipação crônica funcional: com que fibra suplementar?

Maffei¹

2004

J. Pediatr. (Rio J.)

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Dietary fiber (DF) increases fecal weight by mechanisms that depend on the structure of its components and on the intricate relationship between its physico-chemical properties (water-holding capacity, solubility, particle size, degree of lignification, pentose concentrations, etc.) and the bacterial population of the colon. As the insoluble components of the fiber resist bacterial breakdown, they are eliminated intact and keep the retained water, generating high fecal weight. During the colonic transit this large bulk stimulates propulsive contractions and, transit time being shortened, there might be less water reabsorption, feces becoming wetter. In contrast, 90-100% of the soluble fibers (but just 30-80% of the insoluble) are fermented by the intestinal flora, liberating the retained water and producing shortchain fatty acids. These acids are absorbed, generating water absorption and electrolyte co-absorption, which together with the absorption of the liberated water tends to reduce fecal water content. However, fermentation is also a great stimulus for bacterial mass increase, which, making up around 50% of dry feces, contributes to fecal weight. There are indications that fermentation increases with prolonged fiber consumption, since the bacterial flora polysaccharidases are inducible. Summing up, the main characteristics required for good laxation are attributed to the insoluble fraction of fiber, the soluble fraction playing a contributory role, although it does fulfill other important metabolic functions. 1,2 In addition, excess fermentation has undesirable clinical effects.Variations occur depending on whether fibers are ingested pure, as in many experiments, or as ingredients in foods. For example, pure cellulose isolated from wood is less digestible than that of fruit and vegetable because it is highly crystallized and has a small surface area. Wheat bran, having highly lignified cell walls, ferments less than cabbage or apples,

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confidence: 78%

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Constipação crônica funcional: com que fibra suplementar?

Maffei¹

2004

J. Pediatr. (Rio J.)

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“…Se considera que la fibra impide la absorción de hierro a nivel intestinal (25) . Sin embargo, Feltrin señala que la fibra soluble de pectina no impide la absorción intestinal de hierro (26) .…”

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Efecto terapéutico del extracto etanólico de Erythroxylum coca spp. en anemia ferropénica inducida en ratas Holtzman macho

et al. 2013

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artículos originalesEfecto terapéutico del extracto etanólico de Erythroxylum coca spp. en anemia ferropénica inducida en ratas Holtzman macho ResumenIntroducción: La hoja de coca ha sido usada tradicionalmente con fines medicinales y contiene altos niveles de hierro. Objetivos: Determinar el efecto del extracto etanólico de Erythroxylum coca spp. frente a anemia ferropénica inducida por dieta deficiente en hierro, en ratas Holtzman macho. Diseño: Experimental. Lugar: Laboratorio del Instituto de Patología, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Material biológico: Dieciocho ratas Holtzman macho de 16 días de edad recién destetadas. Intervenciones: Se formó tres grupos de seis ratas cada uno: a) grupo hierro suficiente (HS), recibió 25 g/d de alimento balanceado durante 7 semanas; b) grupo hierro deficiente (HD), recibió 25 g/d de dieta ferropénica durante 7 semanas; y, c) el grupo hierro deficiente -extracto E. coca (HD-EC), recibió 25 g/d de dieta ferropénica durante 7 semanas y a partir de la semana 5 se agregó 18 g/d de extracto de E. coca. Principales medidas de resultados: Nivel sérico de hemoglobina, peso y talla. Resultados: Al finalizar el tratamiento, se observó aumento significativo de la hemoglobina en el grupo HD-EC (p=0,04). Se encontró diferencia significativa en los niveles séricos de hemoglobina entre los grupos HD-EC y HD (p=0,0062). No se encontró diferencia significativa en los valores de hemoglobina entre los grupos HD-EC y HS (p= 0,06). No se evidenció diferencia en el peso y la talla entre los grupos HD y HD-EC (p=0,20 y p=0,23, respectivamente). Conclusiones: E. coca presenta efecto antianémico experimental, sustentado en los resultados de los niveles de hemoglobina. Palabras clave: Coca, anemia ferropénica, hemoglobina, ratas Holtzman. Abstract Introduction: Coca leaf has been traditionally used for medical purposes and contains high iron levels. Objective: To determine the effect of Erythroxylum coca spp. ethanol extract in iron-deficiency anemia induced by iron-deficient diet in male Holtzman rats. Design: Experimental. Setting: Institute of Pathology Laboratory, Universidad Nacional Mayor de San Marcos. Biologic material: Eighteen weaned male Holtzman rats 16 days old. Interventions: Rats were allocated to three groups of six rats each: a) iron-sufficient group (IS) received 25 g/d of balanced diet for 7 weeks; b) iron-deficient group (ID) received 25 g/d of iron-deficient diet for 7 weeks; and, c) irondeficient/E. coca extract group (ID-CE) received 25 g/d of iron-deficient diet for 7 weeks, and in the fifth week 18 g/d of E. coca extract were added. Main outcome measures: Serum hemoglobin level, weight and height. Results: At the end of the treatment, there was significant difference of hemoglobin in the ID-CE group (p=0.04). There was significant difference in serum hemoglobin levels between ID-CE and ID groups (p=0.0062). No significant difference was found in serum hemoglobin levels between ID-CE and IS groups (p=0.06). No significant difference was foun...

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“…Calculations were performed using Jandel Sigma Stat software. Sample size was calculated based on the results of a previous study performed at our laboratory, 13 in which it was observed that rats receiving rations with cellulose exhibited mean±standard deviation for humid fecal weight over three days of 10.7±3.5 g, while the group that received rations without fiber eliminated 1.9±1.2 g of feces during the same period.…”

Section: Methodsmentioning

confidence: 99%

Efeito da fibra do polissacarídeo de soja no peso e na umidade das fezes de ratos em fase de crescimento

Freitas¹,

Motta²,

Amâncio³

et al. 2004

J. Pediatr. (Rio J.)

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Objective: To compare the effect of soy polysaccharide on fecal weight and humidity in growing rats in relation to cellulose and a soy formula without dietary fiber.Methods: Twelve, 21-day-old, Wistar male rats, were distributed into three groups and fed AIN-93G ration with varying amounts of dietary fiber: Polysaccharide Group, 5% fiber in the form of soy polysaccharide; Soy Formula Group, 5% soy formula without fiber; and Cellulose Group, 5% fiber in cellulose form. Feces were collected for three 72-hour periods beginning on days 7, 17 and 27. They were weighed while humid and then dried at 105 o C until a constant weight. The humidity was calculated using the formula [(humid fecal weight -dry fecal weight)/humid fecal weight] X 100.

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Dietary cellulose has no effect on the regeneration of hemoglobin in growing rats with iron deficiency anemia

Cited by 14 publications

References 16 publications

Constipação crônica funcional: com que fibra suplementar?

Constipação crônica funcional: com que fibra suplementar?

Efecto terapéutico del extracto etanólico de Erythroxylum coca spp. en anemia ferropénica inducida en ratas Holtzman macho

Efeito da fibra do polissacarídeo de soja no peso e na umidade das fezes de ratos em fase de crescimento

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