Dietary Chlorella vulgaris effectively alleviates oxidative stress, immunosuppression, and enhances the resistance to Streptococcus agalactiae infection in cadmium-intoxicated Nile tilapia fingerlings

Abdel‐Tawwab, Mohsen; Khalil, Riad H.; Selema, Talal A. M. Abo; Elsamanooudy, Salma I; El-Werwary, Suzan O. M.; Shady, Sherien H.; Monier, Mohamed N.; Ismaiel, Mostafa M. S.

doi:10.1016/j.fsi.2023.108717

Cited by 14 publications

(5 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results could be linked to the high content of bioactive compounds, including protein, fatty acids, polysaccharides, pigments, and phenolic and flavonoid substances, which may stimulate the immune system (Abdel‐Latif, El‐Ashram, Sayed, et al, 2022; Abdel‐Latif, El‐Ashram, Yilmaz, et al, 2022; Abdel‐Latif, Soliman, et al, 2022). Similar researches evoked the potential role of green algae in prompting the innate immune indices in fish (Abdelghany et al, 2020; Abdelhamid et al, 2020; Abdel‐Tawwab, Gewida, et al, 2022; Abdel‐Tawwab, Mousa, et al, 2022; Abdel‐Tawwab et al, 2023; Mahmoud et al, 2020).…”

Section: Discussionmentioning

confidence: 79%

“…Interestingly, Hu et al (2014) described improvement in the antioxidative activities of daidzein‐fed turbot via elevation of SOD and GPx activities alongside reducing the MDA concentrations. In similar studies used other dietary green algae such as S. quadricauda (Abdel‐Tawwab, Gewida, et al, 2022), C. vulgaris (Abdel‐Tawwab et al, 2023; Abdel‐Tawwab, Mousa, et al, 2022) and Nannochloropsis oculata (Abdelghany et al, 2020), significantly increased the antioxidant activity of Nile tilapia. A recent study by Abdel‐Tawwab et al (2023) stated that feeding Nile tilapia fingerlings on a Chlorella ‐based diet significantly upregulated antioxidant‐related genes expression due to the phytochemical compounds abundant in this microalga, which are responsible for ROS‐scavenging functions (Ahmadifar et al, 2021).…”

Section: Discussionmentioning

confidence: 96%

“…Those authors reported that the Chlorella content of polysaccharides and β‐1,3‐glucan were involved in potentiating the immune responses of fish. In another study, Abdel‐Tawwab et al (2023) reported that C. vulgaris ‐based diets downregulated the expression of IL‐1β, IL‐8, IL‐10 , and TNF‐α genes in Nile tilapia fingerlings. They attributed their results to Chlorella 's phytochemical compounds.…”

Section: Discussionmentioning

confidence: 98%

“…The microalga TS was procured from the Microalgae unit of a private fish hatchery, Alexandria, Egypt. The extraction procedures of TS samples were conducted according to the methodology described (Massoumeh et al, 2014), and details were declared in our recently published study (Abdel‐Tawwab et al, 2023).…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Dietary effects of microalga Tetraselmis suecica on growth, antioxidant‐immune activity, inflammation cytokines, and resistance of Nile tilapia fingerlings to Aeromonas sobria infection

Abdel‐Tawwab,

Khalil,

Abdel‐Razek

et al. 2023

Animal Physiology Nutrition

Self Cite

View full text Add to dashboard Cite

The dietary effects of the green microalga Tetraselmis suecica (TS) on the growth, digestive enzymes, immune and antioxidant responses, genes expression, and disease resistance of Nile tilapia (Oreochromis niloticus) fingerlings were investigated. This microalga was mixed with the diet' ingredients at doses of 0.0 (the control), 5, 10, 15, and 20 g/kg diet and then fed to fish daily for 84 days. After the feeding trial, fish were experimentally challenged with Aeromonas sobria, infection and fish mortalities were recorded for another 10 days. Dietary TS significantly (p < 0.05) enhanced growth, digestive enzymes activities, and blood proteins, particularly at the level of 15 g/kg diet. Feeding the fish on 15 TS/kg feed exhibited highest mRNA expressions of GH and IGF‐1 genes as well as SOD, CAT, and GPx genes compared to other TS groups. Moreover, highest levels of hepatic antioxidant and immune indices were found in the treatment of 15 g TS/kg feed. Significant downregulation of IL‐1β and IL‐8 genes expression and significant upregulation of IL‐10 gene expression were observed in TS‐fed fish, principally in fish groups fed on 15−20 g TS/kg feed. Conversely, hepatic malondialdehyde levels, blood glucose, and the activities of transaminases (ALT and AST) were significantly (p < 0.05) decreased in fish fed with 15−20 g TS/kg diet. Serum bactericidal activity against A. sobria was significantly higher in TS‐fed fish groups, and its highest levels were found in treatments of 15−20 g/kg diet. Of interest, the survival rates of fish groups fed diets with 10−20 g TS/kg feed were higher after the challenge with A. sobria infection than the control group. Accordingly, we can conclude that supplementing fish diets with a 15 g TS/kg diet enhanced the growth, antioxidant and immune activities, and resistance of Nile tilapia fingerlings to possible A. sobria infection.

show abstract

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Dietary effects of microalga Tetraselmis suecica on growth, antioxidant‐immune activity, inflammation cytokines, and resistance of Nile tilapia fingerlings to Aeromonas sobria infection

Abdel‐Tawwab,

Khalil,

Abdel‐Razek

et al. 2023

Animal Physiology Nutrition

Self Cite

View full text Add to dashboard Cite

show abstract

“…and Streptococcus agalactiae is a globally dispersed species (Ghetas et al, 2021). Previously, O. niloticus's health has been seriously endangered by S. agalactiae infection (Abdel Rahman et al, 2023;Abdel-Tawwab et al, 2023;Baldissera et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Using Azadirachta indica protein hydrolysate as a plant protein in Nile tilapia (Oreochromis niloticus) diet: Effects on the growth, economic efficiency, antioxidant‐immune response and resistance to Streptococcus agalactiae

Rahman

Amer

Behairy

et al. 2023

Animal Physiology Nutrition

View full text Add to dashboard Cite

A feeding trial for 90 days was conducted on Nile tilapia (Oreochromis niloticus) (average weight: 25.50 ± 0.05 g) to evaluate the effect of dietary inclusion of Azadirachta indica seed protein hydrolysate (AIPH). The evaluation included the impact on the growth metrics, economic efficiency, antioxidant potential, hemato‐biochemical indices, immune response, and histological architectures. A total of 250 fish were randomly distributed in five treatments (n = 50) and received diets included with five levels of AIPH (%): 0 (control diet, AIPH0), 2 (AIPH2), 4 (AIPH4), 6 (AIPH6) or 8 (AIPH8), where AIPH partially replace fish meal by 0, 8.7%, 17.4%, 26.1%, and 34.8%, respectively. After the feeding trial, a pathogenic bacterium (Streptococcus agalactiae, 1.5 × 108 CFU/mL) was intraperitoneally injected into the fish and the survival rate was recorded. The results elucidated that AIPH‐included diets significantly (p < 0.05) enhanced the growth indices (final body weight, total feed intake, total body weight gain, and specific growth rate) and intestinal morpho‐metrics (villous width, length, muscular coat thickness, and goblet cells count) in comparison to the control diet, with the AIPH8 diet recording the highest values. Dietary AIPH inclusion significantly improved (p < 0.05) the economic efficacy indicated by reduced feed cost/kg gain and increased performance index. The fish fed on the AIPH diets had noticeably significantly higher (p < 0.05) protein profile variables (total proteins and globulin) and antioxidant capabilities (superoxide dismutase and total antioxidant capacity) than the AIPH0 group. The dietary inclusion of AIPH significantly (p < 0.05) boosted the haematological parameters (haemoglobin, packed cell volume %, and counts of red blood cells and white blood cells) and immune indices (serum bactericidal activity %, antiprotease activity, and immunoglobulin M level) in a concentration‐dependent manner. The blood glucose and malondialdehyde levels were significantly (p < 0.05) lowered by dietary AIPH (2%−8%). The albumin level and hepatorenal functioning parameters (aspartate aminotransferase, alanine aminotransferase, and creatinine) were not significantly (p > 0.05) altered by AIPH diets. Additionally, AIPH diets did not adversely alter the histology of the hepatic, renal or splenic tissues with moderately activated melano‐macrophage centres. The mortality rate among S. agalactiae‐infected fish declined as dietary AIPH levels rose, where the highest survival rate (86.67%) was found in the AIPH8 group (p < 0.05). Based on the broken line regression model, our study suggests using dietary AIPH at the optimal level of 6%. Overall, dietary AIPH inclusion enhanced the growth rate, economic efficiency, health status, and resistance of Nile tilapia to the S. agalactiae challenge. These beneficial impacts can help the aquaculture sector to be more sustainable.

show abstract

Alternative Protein Sources in Tilapia Feeds: Perspectives from Africa

Maulu,

Odu-Onikosi,

Abarra

et al. 2024

Sustainability Sciences in Asia and Africa

View full text Add to dashboard Cite

Dietary Chlorella vulgaris effectively alleviates oxidative stress, immunosuppression, and enhances the resistance to Streptococcus agalactiae infection in cadmium-intoxicated Nile tilapia fingerlings

Cited by 14 publications

References 75 publications

Dietary effects of microalga Tetraselmis suecica on growth, antioxidant‐immune activity, inflammation cytokines, and resistance of Nile tilapia fingerlings to Aeromonas sobria infection

Dietary effects of microalga Tetraselmis suecica on growth, antioxidant‐immune activity, inflammation cytokines, and resistance of Nile tilapia fingerlings to Aeromonas sobria infection

Using Azadirachta indica protein hydrolysate as a plant protein in Nile tilapia (Oreochromis niloticus) diet: Effects on the growth, economic efficiency, antioxidant‐immune response and resistance to Streptococcus agalactiae

Alternative Protein Sources in Tilapia Feeds: Perspectives from Africa

Contact Info

Product

Resources

About