Dietary d-limonene alleviates insulin resistance and oxidative stress–induced liver injury in high-fat diet and L-NAME-treated rats

Santiago, Jesudoss Victor Antony; Jayaraman, Jayachitra; Madhavan, Shenbagam; Nalini, Namasivayam

doi:10.1007/s00394-011-0182-7

Cited by 75 publications

(24 citation statements)

References 55 publications

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“…, Table ). Among them, camphene was reported to reduce plasma cholesterol and triglycerides in hyperlipidemic rats (Vallianou et al , ) and also other essential oils including limonene (Abdollahi et al , ; Victor Antony Santiago et al , ) are known to exert hypolipidemic activity. Thus, our GC‐MS data support that EOPK, an essential oil mixture, exerts antihyperlipidemic activity in HepG2 cells.…”

Section: Resultsmentioning

confidence: 99%

Essential Oil of Pinus koraiensis Leaves Exerts Antihyperlipidemic Effects via Up‐regulation of Low‐density Lipoprotein Receptor and Inhibition of Acyl‐coenzyme A: Cholesterol Acyltransferase

Kim

Lee

Jeong

et al. 2012

Phytotherapy Research

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Hyperlipidemia is an important factor to induce metabolic syndrome such as obesity, diabetes and cardiovascular diseases. Recently, some antihyperlipidemic agents from herbal medicines have been in the spotlight in the medical science field. Thus, the present study evaluated the antihyperlipidemic activities of the essential oil from the leaves of Pinus koraiensis SIEB (EOPK) that has been used as a folk remedy for heart disease. The reverse transcription polymerase chain reaction (RT-PCR) revealed that EOPK up-regulated low density lipoprotein receptor (LDLR) at the mRNA level as well as negatively suppressed the expression of sterol regulatory element-binding protein (SREBP)-1c, SREBP-2, 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), fatty acid synthase (FAS) and glycerol-3-phosphate acyltransferase (GPAT) involved in lipid metabolism in HepG2 cells. Also, western blotting showed that EOPK activated LDLR and attenuated the expression of FAS at the protein level in the cells. Consistently, EOPK significantly inhibited the level of human acylcoenzyme A: cholesterol acyltransferase (hACAT)1 and 2 and reduced the low-density lipoprotein (LDL) oxidation activity. Furthermore, chromatography-mass spectrometry (GC-MS) analysis showed that EOPK, an essential oil mixture, contained camphene (21.11%), d-limonene (21.01%), α-pinene (16.74%) and borneol (11.52%). Overall, the findings suggest that EOPK can be a potent pharmaceutical agent for the prevention and treatment of hyperlipidemia.

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Section: Resultsmentioning

confidence: 99%

Essential Oil of Pinus koraiensis Leaves Exerts Antihyperlipidemic Effects via Up‐regulation of Low‐density Lipoprotein Receptor and Inhibition of Acyl‐coenzyme A: Cholesterol Acyltransferase

Kim

Lee

Jeong

et al. 2012

Phytotherapy Research

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“…Considering its anticancer activity, the aim of this study was to develop solid lipid nanoparticles (SLNs) for (+)-limonene 1,2-epoxide (Lim-SLNs), and test the effect of the particles on the release profile, antioxidant activity, and cytotoxicity in a keratinocyte cell line. Several reports confirm that (+)-limonene 1,2-epoxide can induce tumor cell apoptosis, as well as suppression of the PI3K/Akt/mTOR17 and NF-κB pathways [39]. Phase I clinical trials have been reported by Vigushin et al for this monoterpene derivative [40].…”

Section: Introductionmentioning

confidence: 89%

(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line

Souto

Zielińska

Souto

et al. 2020

IJMS

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In this work, we developed a solid lipid nanoparticle (SLN) formulation with (+)-limonene 1,2-epoxide and glycerol monostearate (Lim-SLNs), stabilized with Poloxamer® 188 in aqueous dispersion to modify the release profile of the loaded monoterpene derivative. We also evaluated the role of SLNs in lipid peroxidation and cytotoxicity in a spontaneously transformed aneuploid immortal keratinocyte cell line from adult human skin (the HaCaT cell line). For the cell viability assay, the colorimetric 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay was used. Lim-SLNs with a loading capacity and encapsulation efficiency of 0.39% and 63%, respectively, were produced by high pressure homogenization. A mean particle size of 194 ± 3.4 nm and polydispersity index of 0.244 were recorded for the loaded Lim-SLNs, as compared to 203 ± 1.5 nm (PI 0.213) for the non-loaded (blank) SLNs. The loading of the monoterpene derivative into glycerol monostearate SLNs fitted into the zero-order kinetics, and ameliorated both lipid peroxidation and cytotoxicity in a keratinocyte cell line. A promising formulation for antioxidant and anti-tumoral activities is here proposed.

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“…Monoterpenes such as limonene, and menthol consist of two isoprene units, and are major constituent of essential oils obtained from citrus fruits, cherries, spearmint dill, caraway, apricots and grapes. Rats supplemented with d-limonene result in reduced highfat diet-induced hepatic lipid level, lipid peroxidation, increased phase II enzymes activities, and decreased liver and pancreas pathology that against metabolic syndrome [159] (Table 3). Menthol is found to suppress bone resorption by inhibition of osteoclastogenesis via interfere with RANKL signaling [160].…”

Section: Terpenoidsmentioning

confidence: 98%

Molecular mechanisms for anti‐aging by natural dietary compounds

Pan

Lai

Tsai

et al. 2011

Molecular Nutrition Food Res

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Aging is defined as a normal decline in survival with advancing age; however, the recent researches have showed that physiological functions of the body change during the aging process. Majority of the changes are often subject to a higher risk of developing diseases, such as cardiovascular disease, type II diabetes, Alzheimer's disease, Parkinson's disease, as well as the dysregulated immune and inflammatory disorders. Aging process is controlled by a complicated and precise signaling network that involved in energy homeostasis, cellular metabolism and stress resistance. Over the past few decades, research in natural dietary compounds by various organism and animal models provides a new strategy for anti-aging. Natural dietary compounds act through a variety mechanisms to extend lifespan and prevent age-related diseases. This review summarizes the current understanding on signaling pathways of aging and knowledge and underlying mechanism of natural dietary compounds that provide potential application on anti-aging and improve heath in human.

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Dietary d-limonene alleviates insulin resistance and oxidative stress–induced liver injury in high-fat diet and L-NAME-treated rats

Abstract: These data provide new insights into the therapeutic approach of d-limonene against the development of the metabolic syndrome associated with NAFLD.

Cited by 75 publications

References 55 publications

Essential Oil of Pinus koraiensis Leaves Exerts Antihyperlipidemic Effects via Up‐regulation of Low‐density Lipoprotein Receptor and Inhibition of Acyl‐coenzyme A: Cholesterol Acyltransferase

Essential Oil of Pinus koraiensis Leaves Exerts Antihyperlipidemic Effects via Up‐regulation of Low‐density Lipoprotein Receptor and Inhibition of Acyl‐coenzyme A: Cholesterol Acyltransferase

(+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line

Molecular mechanisms for anti‐aging by natural dietary compounds

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