Dietary Energy Density and Postmenopausal Breast Cancer Incidence in the Cancer Prevention Study II Nutrition Cohort

Hartman, Terryl J.; Gapstur, Susan M.; Gaudet, Mia M.; Shah, Roma; Flanders, W. Dana; Wáng, Ying; McCullough, Marjorie L.

doi:10.3945/jn.116.234344

Cited by 17 publications

(9 citation statements)

References 36 publications

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“…Roon et al (2018) evidenciam que uma dieta hipocalórica, associado ou não a atividade física, auxilia na manutenção dos hormônios sexuais endógenos, relacionados a esta doença, em mulheres na pós-menopausa, com excesso de peso e sedentárias. Hartman et al (2016), em sua pesquisa, avaliaram a densidade energética total da dieta de 56.795 mulheres na pós-menopausa e constataram que havia uma associação discreta com risco de neoplasia de mama. Catsburg et al (2015), por sua vez, realizaram uma pesquisa com 49.410 indivíduos no National Breast Screening Study -que avaliou o padrão alimentar -, constatando que o consumo de maior quantidade de vegetais relacionou-se com um risco menor de desenvolver neoplasia mamária; por outro lado, o padrão alimentar que incluía carnes aumentava o risco.…”

Section: Resultsunclassified

Os impactos da alimentação na prevenção do câncer de mama: uma revisão da literatura

Pereira

Spinelli

Zemolin

et al. 2020

PERSP

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O câncer de mama é caracterizado pelo crescimento anormal e desordenado de células no tecido mamário. Esta neoplasia é a mais frequente em mulheres de todo o mundo. Nenhum alimento isolado possui efeito protetor contra o câncer, porém o seu desenvolvimento pode estar relacionado com a inadequação alimentar. Sendo assim, o objetivo do presente estudo foi realizar uma revisão bibliográfica sobre os impactos da alimentação na prevenção do câncer de mama, mediante leitura sistemática, com fichamento de cada obra, ressaltando os pontos abordados pelos autores pertinentes ao assunto em questão. Nesta pesquisa foi utilizado o método dedutivo exploratório de caráter científico que revisou as seguintes palavras-chave: câncer de mama, alimentação, nutrição, câncer e influência, bem como suas correlatas em inglês. Foram utilizadas as bases de dados PubMed, Instituto Nacional do Câncer (INCA), Science Direct, Revistas e Jornais Científicos Internacionais, com datas entre 2007 e 2018. Os estudos evidenciam que uma alimentação adequada e saudável consegue colaborar para prevenir o câncer de mama em mulheres, independendo da fase da vida; e a adoção de uma alimentação que priorize alimentos in natura e minimamente processados, aliada ao estilo de vida, pode garantir um melhor prognóstico.

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Section: Resultsunclassified

Os impactos da alimentação na prevenção do câncer de mama: uma revisão da literatura

Pereira

Spinelli

Zemolin

et al. 2020

PERSP

View full text Add to dashboard Cite

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“…Despite knowing that a decrease in obesity is related to a decreased breast cancer risk, the optimal intensity level to decrease breast cancer risk in postmenopausal women is still under-defined ( 30 ). Previous studies have established that obesity has an association with breast cancer risk among postmenopausal subjects ( 4 - 8 , 10 , 11 , 23 - 32 , 53 ), particularly a dose-response relationship ( 30 , 37 ). While the current study adjusted for BMI as a confounding factor, given majority of this study cohort are overweight or obese (>60% and 70% among pre- and post-menopausal women, respectively), residual confounding may still occur due to inaccurate self-report measures.…”

Section: Discussionmentioning

confidence: 99%

Association between breast cancer risk and leisure physical activity in a rural cohort population

Stahr¹,

Runnells²,

Rogers³

et al. 2019

Transl. Cancer Res

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Background Physical activity has been identified as a modifiable risk factor for breast cancer. Varying definitions of physical activity have made the evaluation difficult to analyze. In a state with high prevalence of obesity and elevated rates of breast cancer incidence and mortality, physical activity may be an important element for risk reduction. Women’s participation in physical activity and the relation to breast cancer incidence has rarely been determined in the southern states where obesity are prevalent. Methods Associations between various levels of physical activity and incident breast cancer cases among 21,665 subjects residing in Arkansas from 2007–2018 were completed. Multivariate logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (95% CI), adjusting for various risk factors such as age, alcohol use, education, region, ethnicity, age at menarche, ever had children, and history of breastfeeding and family history of breast cancer. Stratification on menopausal status was performed to observe any breast cancer differences within the different biological pathways. Results Among premenopausal subjects, inverse associations were observed among increase time in walking (OR =0.63, 95% CI: 0.36–1.11 and OR =0.47, 95% CI: 0.26–0.83) and overall weekly physical activity (OR =0.89, 95% CI: 0.50–1.57 and OR =0.52, 95% CI: 0.30–0.90) and breast cancer. No association was evident between the risk for breast cancer and physical activity among postmenopausal subjects. The relationship between physical activity and risk for breast cancer differed between menopausal statuses. The most apparent association was seen among premenopausal subjects with an increase in walking (P=0.01). Conclusions Although physical activity has been demonstrated to have a beneficial effect on breast cancer prevention among postmenopausal women, results from this study do not sufficiently support the hypothesis in this population. Results varied among menopausal status as well as among different definitions of physical activity. Further investigation is needed to identify factors contributing to de-attenuating the relationships.

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“…Recently, researchers have begun to question the way fat and sugar are quantified in dietary studies and have explored using surrogate measures. Energy density (ED), the ratio of energy intake to food weight, has been shown to significantly increase the risk of breast cancer in observational cohort studies with an RR as high as 1.20, comparing the highest to lowest quintiles (Hartman et al 2016, Thomson et al 2018. Another way of measuring the type of food being ingested is the degree of processing that occurred during food preparation.…”

Section: Alternative Ways To Categorize Foodmentioning

confidence: 99%

Dietary Fat and Sugar in Promoting Cancer Development and Progression

Goncalves

Hopkins

Cantley

2019

Annu. Rev. Cancer Biol.

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The uncontrolled cellular growth that characterizes tumor formation requires a constant delivery of nutrients. Since the 1970s, researchers have wondered if the supply of nutrients from the diet could impact tumor development. Numerous studies have assessed the impact of dietary components, specifically sugar and fat, to increased cancer risk. For the most part, data from these trials have been inconclusive; however, this does not indicate that dietary factors do not contribute to cancer progression. Rather, the dietary contribution may be dependent on tumor, patient, and context, making it difficult to detect in the setting of large trials. In this review, we combine data from prospective cohort trials with mechanistic studies in mice to argue that fat and sugar can play a role in tumorigenesis and disease progression. We find that certain tumors may respond directly to dietary sugar (colorectal and endometrial cancers) and fat (prostate cancer) or indirectly to the obese state (breast cancer).

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Dietary Energy Density and Postmenopausal Breast Cancer Incidence in the Cancer Prevention Study II Nutrition Cohort

Abstract: These results suggest a modest positive association between total dietary ED and risk of postmenopausal breast cancer.

Cited by 17 publications

References 36 publications

Os impactos da alimentação na prevenção do câncer de mama: uma revisão da literatura

Os impactos da alimentação na prevenção do câncer de mama: uma revisão da literatura

Association between breast cancer risk and leisure physical activity in a rural cohort population

Dietary Fat and Sugar in Promoting Cancer Development and Progression

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