Dietary exposure of juvenile female mice to polyhalogenated seafood contaminants (HBCD, BDE-47, PCB-153, TCDD): Comparative assessment of effects in potential target tissues

Maranghi, Francesca; Tassinari, Roberta; Moracci, Gabriele; Altieri, Ilaria; Rasinger, Josef Daniel; Carroll, Thomas; Högstrand, Christer; Lundebye, Anne‐Katrine; Mantovani, Alberto

doi:10.1016/j.fct.2013.02.056

Cited by 48 publications

(71 citation statements)

References 36 publications

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“…Our Low-dose of 10 μg/kg bw/day can thus be speculated to contribute to the observed liver toxicity. PCB153 has been shown to cause liver injury in mice following exposure to 195 μg/kg bw/day for 28 days, which gives an accumulated dose of 5.4 mg/kg bw [43]. In comparison, our accumulated Low-dose was 1.8 mg/kg bw (20 μg/kg bw/day).…”

Section: Discussionmentioning

confidence: 93%

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

et al. 2016

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Humans are exposed to a large number of environmental chemicals in their daily life, many of which are readily detectable in blood or urine. It remains uncertain if these chemicals can cause adverse health effects when present together at low doses. In this study we have tested whether a mixture of 27 chemicals administered orally to juvenile male rats for three months could leave a pathophysiological footprint. The mixture contained metals, perfluorinated compounds, PCB, dioxins, pesticides, heterocyclic amines, phthalate, PAHs and others, with a combined dose of 0.16 (Low dose), 0.47 (Mid dose) or 1.6 (High dose) mg/kg bw/day. The lowest dose was designed with the aim of obtaining plasma or urine concentrations in rats at levels approaching those observed in humans. Some single congeners were administered at doses representative of combined doses for chemical groups. With this baseline, we found effects on weight, histology and gene expression in the liver, as well as changes to the blood plasma metabolome in all exposure groups, including low-dose. Additional adverse effects were observed in the higher dosed groups, including enlarged kidneys and alterations to the metabolome. No significant effects on reproductive parameters were observed.

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Section: Discussionmentioning

confidence: 93%

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

et al. 2016

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“…This might be a chance finding, which would be supported by the fact that we did not see any association between calculated free testosterone/estradiol ratio and PCB exposures. However, one animal study with female mice showed significantly elevated testosterone/estradiol ratio after exposure to several halogenated organic compounds, though not after PCB153 exposure (30), suggesting an inhibition on the aromatase activity (a CYP19 enzyme) that controls the androgen/estrogen ratio (31). …”

Section: Discussionmentioning

confidence: 99%

Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls

Petersen

Halling

Jensen

et al. 2015

Environmental Research

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Background Endocrine disrupting industrial chemicals, such as polychlorinated biphenyls (PCBs), are suspected to adversely affect male reproductive functions. Objectives The Faroe Islands community exhibits an unusually wide range of exposures to dietary contaminants, and in this setting we examined the possible association between PCB exposure and semen quality and reproductive hormones in fertile Faroese men. Methods Participants in this cross-sectional study include 266 proven fertile men residing in the Faroe Islands. PCB levels and hormone profiles were measured in serum samples taken at the clinical examination that included semen quality parameters. Results A significant positive association was seen between serum-PCB and the testosterone/estradiol ratio (p=0.04). In the unadjusted analyses, elevated PCB exposure was associated with increased serum concentrations of SHBG (p=0.01) and FSH (p=0.05). We found no association between the serum PCB concentration and the semen quality variables. Conclusion In this population of highly exposed fertile men, the current serum-PCB concentration was associated with higher androgen/estrogen ratio. Further studies are needed to establish the findings and further document PCB-associated hormonal effects, any time windows of increased susceptibility, and the role of PCB in sub-fecundity.

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“…Infants exposed to high levels of PCB and hexachlorobenzene (another bioaccumulating ED that may alter the metabolism of thyroid hormones) through fish in their diet demonstrated only modest changes in thyroid parameters, possibly due to a protective effect of the iodine also present in fish [76]. However, when juvenile mice are exposed to levels of persistent lipophilic pollutants devoid of any apparent toxicity by fish-based diets, subtle but clearly adverse effects are observed in the brain, liver, thymus and thyroid [77,78]. These studies suggest that intake via the fish food matrix could not afford a detectable protection to the developing organism.…”

Section: Factors Modulating the Ed-associated Health Risks: Life Stagmentioning

confidence: 99%

Endocrine Disrupters and the Safety of Food Chains

Mantovani¹

2015

Horm Res Paediatr

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Endocrine disrupters (ED) are a heterogeneous group of chemicals including persistent contaminants, pesticides, as well as compounds present in consumer products and natural substances. For most ED, the food chain is a current major exposure route for the general population. ED can enter the food chain through the living environment (e.g., feeds, fertilizers) of food-producing organisms, be directly employed in food production (e.g., pesticides) or be released from food contact materials (such as bisphenol A or phthalates); in addition, the endocrine disruption potential of some natural compounds in edible plants, including the so-called phytoestrogens, should not be overlooked. An exposure assessment has to consider the specific liability of food commodities to contamination with specific ED (e.g., polychlorinated and polybrominated chemicals in lipid-rich foods). The paper discusses the main toxicological research issues in order to support the risk assessment of ED in food chains, including: the potential for additive, ‘cocktail' effects (as from multiple pesticide residues); the long-term effects on target body systems (e.g., reproductive, nervous) elicited by exposure during prenatal as well as postnatal life stage windows, and toxicant/nutrient interactions (e.g., thyroid-targeting ED and iodine status). Food safety systems should exploit the available knowledge to improve prevention of long-term risks along the whole food chain.

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Dietary exposure of juvenile female mice to polyhalogenated seafood contaminants (HBCD, BDE-47, PCB-153, TCDD): Comparative assessment of effects in potential target tissues

Cited by 48 publications

References 36 publications

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

Juvenile Male Rats Exposed to a Low-Dose Mixture of Twenty-Seven Environmental Chemicals Display Adverse Health Effects

Spermatogenic capacity in fertile men with elevated exposure to polychlorinated biphenyls

Endocrine Disrupters and the Safety of Food Chains

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