Dietary Exposure of Juvenile Rainbow Trout (<i>Oncorhynchus mykiss</i>) to 1,2-<i>bis</i>(2,4,6-tribromo- phenoxy)ethane:  Bioaccumulation Parameters, Biochemical Effects, and Metabolism

Tomy, Gregg T.; Palace, Vince; Pleskach, Kerri; Ismail, Nargis; Oswald, Tyler; Danell, Robert; Wautier, Kerry; Evans, Bob

doi:10.1021/es070288t

Cited by 60 publications

(48 citation statements)

References 15 publications

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“…BMFs for walleye ranged from 0.4 to 2.5 depending on the prey. The propensity of BTBPE to biomagnify was confirmed in a laboratory feeding study in juvenile rainbow trout (Oncorhynchus mykiss) [31]. BTBPE was taken up from the gut with an assimilation efficiency of 27% over the 49 day feeding period, resulting in a BMF of 2.3.…”

Section: Invertebrates and Fishmentioning

confidence: 84%

Emerging Brominated Flame Retardants in the Environment

Wit

Kierkegaard

Ricklund

et al. 2010

The Handbook of Environmental Chemistry

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A number of new brominated flame retardants (BFRs) are being found in the environment but the amount of data is still very small. The best studied emerging BFRs are 1,2-bis(2,4,6-tribromophenoxy)ethane and decabromodiphenyl ethane, with some data for hexabromobenzene, pentabromoethylbenzene, pentabromotoluene, tetrabromobisphenol A derivatives, bis(2-ethylhexyl) tetrabromophthalate, 2-ethylhexyltetrabromobenzoate, 1,2-dibromo-4-(1,2-dibromoethyl) cyclohexane, and 2,4,6-tribromophenol. Very little data are available for 2,4,6-tribromophenyl allyl ether, 2,3-dibromopropyl-2,4,6-tribromophenyl ether, hexachlorocyclopentadienyldibromocyclooctane, tris(2,3-dibromopropyl) isocyanurate, tetrabromophthalic anhydride, 1,2,5,6-tetrabromocyclooctane, and octabromo-1,3,3-trimethyl-1-phenylindane. Indoor air concentrations are generally higher than outdoor air concentrations, indicating emissions from flame-retarded products. Their presence in indoor air and dust indicates possible human exposure from this pathway, but there are little human data available to determine this. The presence of several of these BFRs in fish, birds, and mammals indicates that they are bioavailable and can be absorbed and bioaccumulated. Their presence in outdoor air and in the Arctic indicates that several are capable of long range atmospheric transport. More data on these new BFRs are needed in order to determine if they pose unacceptable risks to the environment and to human health.

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Section: Invertebrates and Fishmentioning

confidence: 84%

Emerging Brominated Flame Retardants in the Environment

Wit

Kierkegaard

Ricklund

et al. 2010

The Handbook of Environmental Chemistry

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“…Decreases in total T4 and induction of T4-glucuronosyl transferase seem to suggest that HBCD may act in a similar manner to that of the PBDEs, likely through interaction with PXR (Fery et al, 2009;van der Ven et al, 2006). On the contrary, BTBPE was shown not to act on the thyroid system in rainbow trout (Oncorhynchus mykiss) (Tomy et al, 2007), although it does exert thyroid-disrupting effects in chicken embryonic hepatocytes (Egloff et al, 2011). Additional toxicity studies are required to rule out or confirm the disruptive ability of these compounds and other brominated flame retardants still poorly studied.…”

Section: Alternative Flame Retardantsmentioning

confidence: 94%

Deiodinases and thyroid metabolism disruption in teleost fish

Jarque

Piña

2014

Environmental Research

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“…per day) for 49 days, resulted in an average concentration in muscle of about 0.3 µg/kg (Tomy et al, 2007). The uptake curve suggested that BTBPE did not reach steady state in fish at the end of the exposure period.…”

Section: Hazard Identificationmentioning

confidence: 99%

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

2012

EFS2

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EFSA was asked to deliver a scientific opinion on brominated flame retardants (BFRs) other than PBDEs, PBBs, HBCDDs, TBBPA and brominated phenols and their derivatives. The BFRs that are the subject of the current opinion, were classified in groups termed "emerging" and "novel" BFRs. Information on 17 emerging and 10 novel BFRs was collected. The information varied widely for these BFRs. There is a lack of experimental data on physico-chemical characteristics, stability/reactivity and current use and production volume of all the emerging and novel BFRs. Due to the very limited information on occurrence, exposure and toxicity, the CONTAM Panel could not perform a risk characterisation for any of the BFRs considered. Instead, an attempt was made to identify those BFRs that could be a potential health concern and should be considered first for future investigations. For this purpose the Panel first evaluated the available experimental data on occurrence in food, behaviour in the environment and toxicity. Secondly, a modelling exercise was performed focussing on the potential of the emerging and novel BFRs for persistence in the environment and for their possible bioaccumulation potential. There is convincing evidence that tris(2,3-dibromopropyl) phosphate (TDBPP) and dibromoneopentyl glycol (DBNPG) are genotoxic and carcinogenic, warranting further surveillance of their occurrence in the environment and in food. Based on the limited experimental data on environmental behaviour, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and hexabromobenzene (HBB) were identified as compounds that could raise a concern for bioaccumulation. For the modelling exercise, the CONTAM Panel selected two environmental characteristics, overall persistence and potential for bioaccumulation, as being most relevant to provide insight into the possibility that emerging or novel BFRs The less well known and less studied BFRs, subject of the current opinion, were grouped into two classes, referred to herein as "emerging" and "novel" BFRs. Emerging BFRs are defined as chemicals which are applied as flame retardants and that have been identified in any environmental compartment, in wildlife, in food or in humans. It should be noted that the definition for the emerging BFRs, used in this opinion, does not imply that there is evidence for an increasing trend in the concentration of these BFRs in the environment, in food or in human samples. Novel BFRs are defined as chemicals applied as flame retardants, with confirmed presence in materials and/or goods in concentrations above 0.1 %, but not identified in environmental samples, wildlife, food or humans. In total, information on 27 BFRs, of which 17 were identified as "emerging" and 10 as "novel", was collected by the CONTAM Panel, and it was noted that the available information varied widely for the various individual BFRs.In general, there is a lack of experimental data on physico-chemical characteristics and stability/reactivity for all the emerging and novel BFRs. This sometimes hampered ...

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Dietary Exposure of Juvenile Rainbow Trout (Oncorhynchus mykiss) to 1,2-bis(2,4,6-tribromo- phenoxy)ethane: Bioaccumulation Parameters, Biochemical Effects, and Metabolism

Cited by 60 publications

References 15 publications

Emerging Brominated Flame Retardants in the Environment

Emerging Brominated Flame Retardants in the Environment

Deiodinases and thyroid metabolism disruption in teleost fish

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

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