Dietary exposure to mercury and its relation to cytogenetic instability in populations from “La Mojana” region, northern Colombia

Galeano-Páez, Claudia; Espitia-Pérez, Pedro; Jiménez-Vidal, Luisa; Pastor-Sierra, Karina; Salcedo-Arteaga, Shirley; Hoyos-Giraldo, Luz Stella; Gioda, Adriana; Saint’Pierre, Tatiana Dillenburg; García, Solange Cristina; Brango, Hugo; Espitia-Pérez, Lyda

doi:10.1016/j.chemosphere.2020.129066

Cited by 11 publications

(6 citation statements)

References 77 publications

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“…The genotoxic effect of MeHg exposure was reflected in the increased number of MNPCE in exposed mice. Many studies have already demonstrated the genotoxic effects of mercury in fish ( 5 , 6 ), rats in vivo ( 35 ) and in vitro ( 36 ), humans ( 37 ), and tadpoles ( 38 ). The genotoxicity of mercury was also demonstrated by the comet assay ( 6 , 35 , 36 ).…”

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury

Cunha

Bonfim

Lima

et al. 2022

Braz J Med Biol Res

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Non-biodegradable metals such as mercury accumulate in living organisms during life (bioaccumulation) and also within trophic webs (biomagnification) and may reach high concentrations in humans. The contamination of humans by mercury in drinking water and food may be common, in particular in riverside communities that have a diet rich in fish. In vitro studies of human cell lines exposed to the cytotoxic and mutagenic effects of methylmercury have shown that prolactin has potential cytoprotective properties and may act as a co-mitogenic factor and inhibitor of apoptosis. The present in vivo study investigated the protective potential of prolactin against the toxic effects of methylmercury in the mammal Mus musculus . Histological and biochemical analyses, together with biomarker of genotoxicity, were used to verify the protective potential of prolactin in mice exposed to methylmercury. The reduction in kidney and liver tissue damage was not significant. However, results of biochemical and genotoxic analyses were excellent. After prolactin treatment, a significant reduction was observed in biochemical parameters and mutagenic effects of methylmercury. The study results therefore indicated that prolactin has protective effects against the toxicity of methylmercury and allowed us to suggest the continuation of research to propose prolactin in the future, as an alternative to prevent the damage caused by mercury, especially in populations that are more exposed.

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Section: Discussionmentioning

confidence: 99%

In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury

Cunha

Bonfim

Lima

et al. 2022

Braz J Med Biol Res

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“…In relation to genetic damage, Hg for example, favors genetic instability by the loss of chromosomal fragments leading to the formation of micronuclei, which has been evidenced in humans (Galeano-Páez et al, 2021) and animals, mainly in fish (Hovhannisyan et al, 2017;Hussain et al, 2018). In that sense, changes and damage to genetic material in living organisms can be easily evidenced by counting cellular abnormalities including MN, CNB and BC.…”

Section: Growth Condition and Genotoxic Effects In Fishmentioning

confidence: 99%

“…In addition, it has been reported that high consumption of Hgcontaminated fish can increase nuclear damage in human populations (Galeano-Páez et al, 2021). Accumulation of toxic metal(loids) such as Hg and As in fish can reduce reproductive capacity, disrupt enzymatic processes, and substantially affect the immune system, increasing the risk of decline of mainly aquatic fauna (Hussain et al, 2018;Kumari et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Toxic metal(loids) levels in the aquatic environment and nuclear alterations in fish in a tropical river impacted by gold mining

Córdoba-Tovar

Marrugo‐Negrete

Barón

et al. 2023

Environmental Research

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“…Exposure to Hg can lead to detrimental effects in many organ systems. Even exposure to low doses of Hg (e.g., 1–2 meals of non‐contaminated fish) can cause toxicological consequences in target organs 110 …”

Section: Emerging Topics In Toxicity: Metals and Metalloids Of Enviro...mentioning

confidence: 99%

“…Even exposure to low doses of Hg (e.g., 1-2 meals of non-contaminated fish) can cause toxicological consequences in target organs. 110 Mercury transport pathways: Involvement in toxicity and detoxification.…”

Section: Mercurymentioning

confidence: 99%

Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4

Hafey

Aleksunes

Bridges

et al. 2022

Clin Pharma and Therapeutics

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Over the last decade, significant progress been made in elucidating the role of membrane transporters in altering drug disposition, with important toxicological consequences due to changes in localized concentrations of compounds. The topic of “Transporters and Toxicity” was recently highlighted as a scientific session at the International Transporter Consortium (ITC) Workshop 4 in 2021. The current white paper is not intended to be an extensive review on the topic of transporters and toxicity but an opportunity to highlight aspects of the role of transporters in various toxicities with clinically relevant implications as covered during the session. This includes a review of the role of solute carrier transporters in anticancer drug‐induced organ injury, transporters as key players in organ barrier function, and the role of transporters in metal/metalloid toxicity.

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Dietary exposure to mercury and its relation to cytogenetic instability in populations from “La Mojana” region, northern Colombia

Cited by 11 publications

References 77 publications

In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury

In vivo evaluation of the potential protective effects of prolactin against damage caused by methylmercury

Toxic metal(loids) levels in the aquatic environment and nuclear alterations in fish in a tropical river impacted by gold mining

Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4

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