Dietary exposure to tetracycline residues through milk consumption in Iran

Aalipour, Fathollah; Mirlohi, Maryam; Jalali, Mohammad; Azadbakht, Leila

doi:10.1186/s40201-015-0235-6

Cited by 53 publications

(36 citation statements)

References 18 publications

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“…Similarly, frequency of positive farm bulk tank milk (40 %) was found to be higher in a study from Serbia (Petrović et al 2008). Also results obtained for market raw cow's milk in the present study were comparable to those found in a study from Iran (19.78 %) (Aalipour et al 2015). Nevertheless, contamination of marketed fermented cow's milk was lower than results attained for raibi milk (50 %) in the study of Zinedine et al (2007).…”

Section: Discussionsupporting

confidence: 84%

Assessment of antibiotic residues in commercial and farm milk collected in the region of Guelma (Algeria)

Layada¹,

Benouareth²,

Coucke

et al. 2016

FoodContamination

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Background:In an attempt to enhance the quality and quantity of food production (especially milk) and in order to prevent, or treat,animal diseases, the use of antibiotics in Algeria follows an increasing trend. The increased use evidently contributes to the emergence of increased contamination levels of antibiotic residues. Results: In this work, two methods were used to detect presence of antibiotic residues in raw and fermented cow's milk collected in Guelma's farms (in Algeria). The screening comprised different points of sale in Guelma province. In a first step a widely used prescreening method based on microbial inhibition assay; Delvotest SP-NT; was used to analyze 131 milk samples. In a second step a liquid chromatography coupled to mass spectrometry (LC-MS/MS) was used. The latter was first optimized for extraction of 36 veterinary drugs of penicillins, quinolones, macrolides, tetracyclines, sulfonamides, and trimethoprim from the collected milk. After simple extraction and dilution, the 194 samples, including those previously tested by the Delvotest SP-NT, were analyzed by LC-MS/MS. Results obtained by both methods were compared. Among the LC-MS/MS findings, 65.46 % of non-conform samples contained authorized residues at levels higher than the MRL, residues without set MRL, or non-authorized residues.Conclusion: The comparison of both methods showed that Delvotest SP-NT is less trustworthy due to number of false negative results. This was further confirmed by LC-MS/MS pointing out the traces of antibiotics in numerous samples. In 65.46 % of milk samples residues of antibiotics were found suggesting a lack of public health controls as well as an evidence of the negligent use of antibiotics in the livestock industry, which both form a risk to public health. This indication should be confirmed by a nationwide study with in-depth analyses of antibiotic's presence in food chain originated from animals. The study offered an LC-MS/MS based analytical method ready to be used in Algerian National Residues Control Plan as a versatile analytical tool to monitor and determine the occurrence of antibiotic multi-residues in milk.

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Section: Discussionsupporting

confidence: 84%

Assessment of antibiotic residues in commercial and farm milk collected in the region of Guelma (Algeria)

Layada¹,

Benouareth²,

Coucke

et al. 2016

FoodContamination

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“…This trend was also observed in Nigeria (Ibrahim et al 2009), where the percentage of contamination with penicillin residues was higher. This convergence confirms the fact that this molecule is one of the most widely used antibiotics in the veterinary sector worldwide (Emiri et al 2014;Aalipour et al 2015).…”

Section: Discussionsupporting

confidence: 73%

Penicillin-G and oxytetracycline residues in beef sold for human consumption in Maroua, Cameroon

et al. 2017

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Background: The contamination of food by chemical hazards is a worldwide public health concern and is a leading cause of trade problems internationally. Based on former work describing the prevalent use and misuse of antibiotics in cattle in the Far North Region of Cameroon, we designed a study to detect antibiotic (penicillin G and oxytetracycline) in beef sold for human consumption in Maroua (Cameroon). To determine the mean concentration of antibiotic residues in beef, sample of liver and muscle were collected from 202 cattle selected randomly in all the slaughterhouses of Maroua and Godola and analyzed using Liquid Chromatographic tandem Mass Spectrometry (LC-MS/MS). Characteristics of the cattle selected (age, sex, breed, body condition score, weight, production system, and pathology, etc.) were also collected before and/or after slaughter -by physical examination and survey, and post mortem examination. Results: Results revealed that out of 202 cattle 41 (20.30%) tested positive for antibiotics in one or more of their organs. The meat of cattle from transhumance system, sick animals and older cattle was more likely to be contained with penicillin G and oxytetracycline residues. The average residues concentration in beef was 17.58 μg/ kg for penicillin G and 240 μg/kg for oxytetracycline. Conclusions: The findings of the present study should be alarming for the legislative authorities in food security and safety. This highlights a very serious problem, both for the consumers of Maroua city and the herders of the region as well as for the whole economy of Cameroon. It is therefore be important that measures be taken at several levels by the actors of the sector (public authorities, veterinary auxiliaries, etc.) to guarantee the safety of the food of animal origin.

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“…Out of 114 samples analyzed, 28.6 and 24.4% of raw and pasteurized milk samples, respectively were positive for oxytetracycline residues. Also, Aalipour, Mirlohi, Jalali, and Azadbakht () in Iran proclaimed 24% of pasteurized milk samples positive for oxytetracycline residues. The percentage of positive samples detected in both the studies was very high as compared to the present study, where only 3.1% of the raw market milk samples were positive for oxytetracycline residues.…”

Section: Resultsmentioning

confidence: 99%

Analysis of antibiotic residues in raw and commercial milk in Punjab, India vis‐à‐vis human health risk assessment

Moudgil

Bedi

Aulakh

et al. 2019

Journal of Food Safety

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The present study quantitatively analyzed the occurrence of antibiotic residues in 524 milk samples (492 raw milk samples from dairy farms and 32 commercial milk samples) from Punjab, India using high-performance liquid chromatography (HPLC).Tetracyclines, sulphonamides, fluoroquinolones (commonly used in veterinary practice in Punjab), and chloramphenicol (banned in food animals in India) were targeted and analyzed using multiresidue HPLC method. Out of 492 dairy farms milk samples, 78 (16%) were found to be positive for antibiotic residues with 20 (4%) exceeded the maximum residue limits (MRLs). Among 32 commercial milk samples, 4 (12.5%) were positive for antibiotic residues with one (3.1%) sample violated the MRL. Assessment of human health risks revealed that the current levels of antibiotic residues in milk pose no significant toxicological effects on the health of consumers. However, the results highlighted an immediate need of effective strategies for prevention of nonprudent use of antibiotics in veterinary practice for safeguarding consumer's health.

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Dietary exposure to tetracycline residues through milk consumption in Iran

Cited by 53 publications

References 18 publications

Assessment of antibiotic residues in commercial and farm milk collected in the region of Guelma (Algeria)

Assessment of antibiotic residues in commercial and farm milk collected in the region of Guelma (Algeria)

Penicillin-G and oxytetracycline residues in beef sold for human consumption in Maroua, Cameroon

Analysis of antibiotic residues in raw and commercial milk in Punjab, India vis‐à‐vis human health risk assessment

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