Dietary factors in women with dysplasia colli uteri associated with human papillomavirus infection

Kwaśniewska, Anna; Charzewska, Jadwiga; Tukendorf, A; Semczuk, M

doi:10.1080/01635589809514638

Cited by 16 publications

(6 citation statements)

References 42 publications

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“…In this study, we observed a non-significant inverse association between the consumption of fruit and cervical dysplasia. Numerous studies have reported on the role of vegetable consumption in the development of cervical neoplasia [9,[24][25][26][27][28][29][30][31][32], with some of these studies showing a protective effect [9,25,28,30,31]. Data from food group analyses have led to a search for the specific nutrients that account for this protective effect.…”

Section: Discussionmentioning

confidence: 99%

The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia

Hwang

Lee

Kim

et al. 2009

Cancer Causes Control

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We evaluated the relationship between the dietary intake of vegetables and fruits, and the risk of cervical intraepithelial neoplasia (CIN) and determined whether these associations were modified by human papillomavirus (HPV) viral load. We enrolled 1,096 women aged 18-65 to participate in a HPV cohort study from March 2006 up to present. For this analysis, we included 328 HPV-positive women (166 controls, 90 CIN I and 72 CIN II/III). The multivariate odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated by multinomial logistic methods. After controlling for potential confounders, we found that a higher HPV viral load was associated with an increased risk of CIN I (OR = 2.68, 95% CI, 1.19-6.04) and CIN II/III (OR = 2.78, 95% CI, 1.15-6.72). The relationships between HPV infection, dietary intake of vegetables and fruits and risk of CIN were not statistically significant. However, subjects with lower intake of vegetables and fruits, and a higher viral load (> or =15.5) have a higher risk of CIN II/III (OR = 2.84(1.26-6.42), interaction p = 0.06 for vegetables; OR = 2.93(1.25-6.87), interaction p = 0.01 for fruits), compared with subjects with lower intake of vegetables and fruits, and a lower viral load (<15.5). Our findings suggest that the dietary intake of vegetables and fruits is associated with the progression of cervical carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia

Hwang

Lee

Kim

et al. 2009

Cancer Causes Control

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“…Although case-control studies suggested an inverse association between vitamin E intake and invasive cervical cancer, 18,31,32 inconsistent results have been reported for noninvasive lesions. 30,[33][34][35][36][37] Two prospective studies suggest a protective effect of dietary beta-carotene 15,16 against HPV persistence, but results from case-control studies on ISC are inconsistent, 22,26,31,38 and a meta-analysis of RCT 7 did not observe a beneficial effect. Folate intake on ISC has been assessed in some case-control studies 26,39 and results were also inconsistent, and a meta-analysis of RCT 7 did not observe an effect.…”

Section: Discussionmentioning

confidence: 99%

Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

González

Travier

Luján-Barroso

et al. 2010

Intl Journal of Cancer

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Some dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean of 9 years of follow‐up, 253 ISC and 817 CIS cases were diagnosed. In the calibrated model, we observed a statistically significant inverse association of ISC with a daily increase in intake of 100 g of total fruits (HR 0.83; 95% CI 0.72–0.98) and a statistically nonsignificant inverse association with a daily increase in intake of 100 g of total vegetables (HR 0.85: 95% CI 0.65–1.10). Statistically nonsignificant inverse associations were also observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for ISC. No association was found regarding beta‐carotene, vitamin D and folic acid for ISC. None of the dietary factors examined was associated with CIS. Our study suggests a possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases.

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“…The incidence of HPV in women with cervical cancer is reported to be 24.8%,12,24 while HPV prevalence in the general population (among women with normal cytology) is 23.7% 13. Risk factors associated with HPV infection include heterosexuality, promiscuity, smoking,26,27 high parity, early sexual debut,3 infection with other sexually transmitted diseases,26 prolonged use of contraceptives, dietary factors, and genetic disorders such as WHIM (warts, hypogammaglobulinemia, immunodeficiency, myelokathexis) syndrome 28,29…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of human papillomavirus immunoglobulin G antibodies among women presenting at the reproductive health clinic of a university teaching hospital in Nigeria

Aminu¹,

Gwafan²,

Inabo³

et al. 2014

IJWH

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BackgroundHuman papillomavirus (HPV) is the cause of 90%–95% of squamous cell cancers. Persistent infection with high-risk HPV can lead to development of precancerous lesions of the cervix in 5%–10% of infected women, and can progress to invasive cervical cancer 15–20 years later. This study was conducted to determine the seroprevalence of HPV immunoglobulin G (IgG) antibodies among women of reproductive age attending a reproductive health clinic at Ahmadu Bello University Teaching Hospital, Zaria, Nigeria.MethodsThe study was descriptive, cross-sectional, and experimental, combining the use of a structured questionnaire and analysis of serum samples obtained from 350 consecutive consenting women. The serum samples were analyzed for IgG antibodies to HPV by enzyme-linked immunosorbent assay.ResultsWe found a seroprevalence of 42.9% (150/350) for IgG antibodies to HPV in these women. Women aged 45–49 years and those who had their sexual debut aged 20–23 years had the highest HPV seroprevalence, ie, 50% (57/114) and 51.1% (46/90), respectively. Presence of antibodies varied according to sociodemographic factors, but was significantly associated with educational status, tribe, and religion (P<0.05). Human papillomavirus infection was not significantly associated with the reproductive characteristics and sexual behavior of the women. Antibodies to HPV were detected in 50.0% (9/18) of women with a family history of cervical cancer and in 30.8% (4/13) of those with a history or signs of WHIM (warts, hypogammaglobulinemia, immunodeficiency, myelokathexis) syndrome as a genetic disorder (P>0.05).ConclusionFurther studies are needed to determine the HPV serotypes and evaluate the risk of natural development of HPV-related malignancies among women in the study area.

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Dietary factors in women with dysplasia colli uteri associated with human papillomavirus infection

Cited by 16 publications

References 42 publications

The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia

The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia

Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

Seroprevalence of human papillomavirus immunoglobulin G antibodies among women presenting at the reproductive health clinic of a university teaching hospital in Nigeria

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