Dietary fat and breast cancer mortality: A systematic review and meta-analysis

Brennan, Sarah; Woodside, Jayne V.; Lunny, Paula M; Cardwell, Christopher; Cantwell, Marie

doi:10.1080/10408398.2012.724481

Cited by 67 publications

(40 citation statements)

References 71 publications

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“…However, the 2007 WCRF/AICR Second Expert Report [ 5 ] followed by the Updated Breast Cancer 2010 Report [ 6 ] found limited evidence on the association between breast cancer risk and dietary components which may contribute to body fat mass. The association between dietary fat has been a topic of debate for more than 20 years, however a recent meta-analysis reported no significant association [ 7 8 ].…”

Section: Introductionmentioning

confidence: 99%

Estrogen deprivation and excess energy supply accelerate 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in C3H/HeN mice

et al. 2015

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BACKGROUND/OBJECTIVESObesity is a risk factor of breast cancer in postmenopausal women. Estrogen deprivation has been suggested to cause alteration of lipid metabolism thereby creating a cellular microenvironment favoring tumor growth. The aim of this study is to investigate the effects of estrogen depletion in combination with excess energy supply on breast tumor development.MATERIALS/METHODSOvariectomized (OVX) or sham-operated C3H/HeN mice at 4 wks were provided with either a normal diet or a high-fat diet (HD) for 16 weeks. Breast tumors were induced by administration of 7,12-dimethylbenz(a)anthracene once a week for six consecutive weeks.RESULTSStudy results showed higher serum concentrations of free fatty acids and insulin in the OVX+HD group compared to other groups. The average tumor volume was significantly larger in OVX+HD animals than in other groups. Expressions of mammary tumor insulin receptor and mammalian target of rapamycin proteins as well as the ratio of pAKT/AKT were significantly increased, while pAMPK/AMPK was decreased in OVX+HD animals compared to the sham-operated groups. Higher relative expression of liver fatty acid synthase mRNA was observed in OVX+HD mice compared with other groups.CONCLUSIONSThese results suggest that excess energy supply affects the accelerated mammary tumor growth in estrogen deprived mice.

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Section: Introductionmentioning

confidence: 99%

Estrogen deprivation and excess energy supply accelerate 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in C3H/HeN mice

et al. 2015

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“…Besides unfavorable tumor characteristics, individual factors such as diet, exercise, and pre-existing medical conditions also affect cancer recurrence and metastasis [ 32 ]. Obesity, chronic inflammation, and insulin resistance are modifiable risk factors that contribute to the development of breast cancer occurrence [ 32 , 33 , 34 , 35 ]. Controlling weight, exercising, and healthy eating could help lowering the risk of breast cancer recurrence as well as protect from other chronic diseases, including CVD.…”

Section: Discussionmentioning

confidence: 99%

The Possible Influence of Mediterranean Diet on Extracellular Vesicle miRNA Expression in Breast Cancer Survivors

Kwon

Cho

et al. 2020

Cancers

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The Mediterranean diet (MD) has been reported to have beneficial effects on breast cancer and cardiovascular diseases. Recently, microRNAs (miRNAs) have been suggested as biomarkers for the diagnosis and disease prognosis in cancer and cardiovascular diseases. We evaluated the influence of the MD on the plasma-derived extracellular vesicle miRNA signature of overweight breast cancer survivors. Sixteen participants instructed to adhere to the MD for eight weeks were included in this study. To curate differentially expressed miRNAs after MD intervention, we employed two methods: significance analysis of microarrays and DESeq2. The selected miRNAs were analyzed using ingenuity pathway analysis. After an eight-week intervention, body mass index, waist circumference, fasting glucose, fasting insulin, and homeostatic model assessment for insulin resistance were significantly improved. Expression levels of 798 miRNAs were comprehensively analyzed, and 42 extracellular vesicle miRNAs were significantly differentially regulated after the eight-week MD (36 were up and 6 were down-regulated). We also identified enriched pathways in genes regulated by differentially expressed 42 miRNAs, which include signaling associated with breast cancer, energy metabolism, glucose metabolism, and insulin. Our study indicates that extracellular vesicle miRNAs differentially expressed as a result of the MD might be involved in the mechanisms that relate to cardiometabolic risk factors in overweight breast cancer survivors.

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“…obesity to achieve weight management and to prevent some types of cancer (including colorectal cancer and breast cancer) 30,31 when combined with total calorie restriction.…”

Section: Low-fat Dietmentioning

confidence: 99%