Dietary Fat Increases Vitamin D-3 Absorption

Dawson‐Hughes, Bess; Harris, Susan S.; Lichtenstein, Alice H.; Dolnikowski, Gregory G.; Palermo, Nancy J.; Rasmussen, Helen

doi:10.1016/j.jand.2014.09.014

Cited by 74 publications

(56 citation statements)

References 21 publications

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“…However, the underlying mechanisms of how dietary fat affects Ca absorption remain unclear. A high fat intake increases circulating estrogen and vitamin D concentrations that would indirectly increase Ca absorption [39, 40]. However, we did not find that estrogen status differed between groups.…”

Section: Discussioncontrasting

confidence: 56%

High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

et al. 2016

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Diet induced obesity has been shown to reduce bone mineral density (BMD) and Ca absorption. However, previous experiments have not examined the effect of high fat diet (HFD) in the absence of obesity or addressed the type of dietary fatty acids. The primary objective of this study was to determine the effects of different types of high fat feeding, without obesity, on fractional calcium absorption (FCA) and bone health. It was hypothesized that dietary fat would increase FCA and reduce BMD. Mature 8-month-old female C57BL/6J mice were fed one of three diets: a HFD (45% fat) enriched either with monounsaturated fatty acids (MUFAs) or with saturated fatty acids (SFAs), and a normal fat diet (NFD; 10% fat). Food consumption was controlled to achieve a similar body weight gain in all groups. After 8wk, total body bone mineral content and BMD as well as femur total and cortical volumetric BMD were lower in SFA compared with NFD groups (P < 0.05). In contrast, femoral trabecular bone was not affected by the SFAs, whereas MUFAs increased trabecular volume fraction and thickness. The rise over time in FCA was greater in mice fed HFD than NFD and final FCA was higher with HFD (P < 0.05). Intestinal calbindin-D9k gene and hepatic cytochrome P450 2r1 protein levels were higher with the MUFA than the NFD diet (P < 0.05). In conclusion, HFDs elevated FCA overtime; however, an adverse effect of HFD on bone was only observed in the SFA group, while MUFAs show neutral or beneficial effects.

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Section: Discussioncontrasting

confidence: 56%

High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

et al. 2016

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“…The mean serum 25OHD levels increase, observed 14 days after a single oral dose of cholecalciferol taken with a 15 g fat meal, is consistent with other studies of our group [14,18]. Although serum 25OHD measurements could be less sensitive to estimate variations on vitamin D absorption than serum cholecalciferol measurements [21], this metabolite of vitamin D has been shown to increase rapidly after vitamin D supplementation, and it has been used to evaluate vitamin D status as well as the effect of vitamin D supplementation [22][23][24].…”

Section: Discussionsupporting

confidence: 91%

Impact of a cholesterol membrane transporter's inhibition on vitamin D absorption: A double-blind randomized placebo-controlled study

Silva

Faulhauber

Leite

et al. 2015

Bone

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“…The vitamin D content was identical in HF and NF diets. As explained above, the rats fed HF diets ingested less food and this might have resulted in decreased vitamin D intake; but, on the other hand, diets with high fat content have been reported to increase vitamin D absorption by the intestine22. In any case, plasma calcidiol concentrations were not decreased in rats fed HF diets.…”

Section: Discussionmentioning

confidence: 90%

Energy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in rats

Raya

Ríos

Pineda

et al. 2016

Sci Rep

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Rats with normal renal function (Experiment 1, n = 12) and uninephrectomized (1/2Nx) rats (Experiment 2, n = 12) were fed diets with normal P (NP) and either normal (NF) or high fat (HF). Rats with intact renal function (Experiment 3, n = 12) were also fed NF or HF diets with high P (HP). Additionally, uremic (5/6Nx) rats (n = 16) were fed HP diets with NF or HF. Feeding the HF diets resulted in significant elevation of plasma FGF23 vs rats fed NF diets: Experiment 1, 593 ± 126 vs 157 ± 28 pg/ml (p < 0.01); Experiment 2, 538 ± 105 vs 250 ± 18 pg/ml (p < 0.05); Experiment 3, 971 ± 118 vs 534 ± 40 pg/ml (p < 0.01). Rats fed HF diets showed P retention and decreased renal klotho (ratio klotho/actin) vs rats fed NF diets: Experiment 1, 0.75 ± 0.06 vs 0.97 ± 0.02 (p < 0.01); Experiment 2, 0.69 ± 0.07 vs 1.12 ± 0.08 (p < 0.01); Experiment 3, 0.57 ± 0.19 vs 1.16 ± 0.15 (p < 0.05). Uremic rats fed HF diet showed more severe vascular calcification (VC) than rats fed NF diet (aortic Ca = 6.3 ± 1.4 vs 1.4 ± 0.1 mg/g tissue, p < 0.001). In conclusion, energy-rich diets increased plasma levels of FGF23, a known risk factor of cardiovascular morbidity and mortality. Even though FGF23 has major phosphaturic actions, feeding HF diets resulted in P retention, likely secondary to decreased renal klotho, and aggravated uremic VC.

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Dietary Fat Increases Vitamin D-3 Absorption

Cited by 74 publications

References 21 publications

High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

High fat diet enriched with saturated, but not monounsaturated fatty acids adversely affects femur, and both diets increase calcium absorption in older female mice

Impact of a cholesterol membrane transporter's inhibition on vitamin D absorption: A double-blind randomized placebo-controlled study

Energy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in rats

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