Dietary fats, the diurnal blood lipids and ketones in juvenile diabetes

Sterky, G; Persson, Bengt; Larsson, Yngve

doi:10.1007/bf01106970

Cited by 15 publications

(2 citation statements)

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“…This often seems to be impossible and such patients are called brittle diabetics. In these cases the basic daily insulin requirement can be met preventing the development of ketoacidosis, severe hypoglycaemia, weight gain or loss and other diabetic symptoms, but there remain wide and unphysiological daily fluctuations in blood glucose and many other metabolites and hormones [1,4,11,21].…”

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confidence: 99%

Regulation of brittle diabetics by a pre-planned insulin infusion programme

Deckert¹,

Lørup²

1976

Diabetologia

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Eleven brittle diabetics, mean duration 11.5 years, all treated with highly purified porcine NPH insulin twice daily, were placed on highly purified porcine regular insulin 4 times daily for 2 days. Thereafter pre-planned intravenous insulin infusion was started. Insulin in an amount corresponding to the daily insulin requirement was infused by a mobile electric infusion pump at precalculated rates between 30 and 7 ml/hour during 2 days. The patients were ambulatory. Capillary blood glucose was taken every 30 min after meals and every two hours during the night. After an equilibration period of 7 hours, blood glucose fluctuations were in the physiological range in nearly all patients during the infusion period. [Only 1.3% of the blood samples showed glucose levels lower than 2.5 mmol/l and 2.9% levels exceeding 10.0 mmol/l during the infusion days]. Mean blood glucose (MBG) was 6.0 +/- 0.9 mmol/l (mean +/- s.d.), the standard deviation of MBG was 1.8 +/- 0.5 mmol/l, the mean amplitude of blood glucose excursions (MAGE) 4.7 +/- 1.4 mmol/l, and glucosuria 3.1 +/- 3.9 g/day. All these data of glucose homeostasis were significantly lower during the infusion days. The incidence of hypoglycaemic attacks was low (0.32/patient/day) and not significantly higher than during NPH treatment. It is concluded that near normal blood glucose fluctuations can be achieved in brittle diabetics by preplanned insulin infusion without blood glucose monitoring.

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Regulation of brittle diabetics by a pre-planned insulin infusion programme

Deckert¹,

Lørup²

1976

Diabetologia

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“…In a study of fasting levels and diurnal variation in blood lipids and acetone bodies in juvenile diabetics, Sterky et al (1966) found the fasting values for FFA and acetone bodies to be elevated in patients on oneinjection therapy, whereas those taking insulin twice a day had normal FFA level, lower acetone bodies in blood and less diurnal variation in blood sugar. The diurnal curves for total BAcBo in our study (Fig.…”

Section: Diabetologia Vol 6 I0mentioning

confidence: 99%