Dietary fatty acid intake, plasma fatty acid levels, and the risk of age-related macular degeneration (AMD): a dose–response meta-analysis of prospective cohort studies

Zhong, Yueyang; Wang, Kai; Jiang, Li; Wang, Jiaming; Zhang, Xiaobo; Xu, Jiancai; Yao, Ke

doi:10.1007/s00394-020-02445-4

Cited by 19 publications

(36 citation statements)

References 76 publications

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“…Epidemiological, clinical, and experimental studies have shown that ω-3 LCPUFA are associated with a decreased risk of AMD and that ω-6 LCPUFA are associated with an increased risk. 63,220…”

Section: Discussionmentioning

confidence: 99%

Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration

Ren¹,

Ren²,

Deng³

et al. 2022

JIR

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Age-related macular degeneration (AMD) is a blinding eye disease, whose incidence strongly increases with ages. The etiology of AMD is complex, including aging, abnormal lipid metabolism, chronic inflammation and oxidative stress. Long-chain polyunsaturated fatty acids (LCPUFA) are essential for ocular structures and functions. This review summarizes the regulatory effects of LCPUFA on inflammation in AMD. LCPUFA are related to aging, autophagy and chronic inflammation. They are metabolized to pro-and anti-inflammatory metabolites by various enzymes. These metabolites stimulate inflammation in response to oxidative stress, causing innate and acquired immune responses. This review also discusses the possible clinical applications, which provided novel targets for the prevention and treatment of AMD and other age-related diseases.

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Section: Discussionmentioning

confidence: 99%

Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration

Ren¹,

Ren²,

Deng³

et al. 2022

JIR

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“…N‐3 PUFAs have also been reported to improve blood circulation 38 ; hence, it is possible that n‐3 PUFA subsequently suppresses choroidal thinning, an effect that may lead to the suppression of myopia progression. N‐3 PUFAs have also been demonstrated to exert anti‐allergic and anti‐inflammatory effects after conversion to active metabolites, as well as to exert direct effects on the myocardium, vessels, brain, and eyes 22,24,26,39–43 …”

Section: Introductionmentioning

confidence: 99%

“…N-3 PUFAs have also been demonstrated to exert anti-allergic and anti-inflammatory effects after conversion to active metabolites, as well as to exert direct effects on the myocardium, vessels, brain, and eyes. 22,24,26,[39][40][41][42][43] Although the ideal ratio in meals of n-6 and n-3 PUFAs has been shown to be 2:1, the consumption of n-6 has increased rapidly, with a ratio of 25:1 since around 1900. 21 This statistic prompted the idea of performing a study to n-3 PUFAs took effects on myopia suppression, enucleated eyes were used for targeted lipidomic analysis, and eicosapentaenoic acid (EPA) were characteristically distributed.…”

Section: Introductionmentioning

confidence: 99%

Lipidomic analysis revealed n‐3 polyunsaturated fatty acids suppressed choroidal thinning and myopia progression in mice

et al. 2022

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Myopia is increasing worldwide and its preventable measure should urgently be pursued. N‐3 polyunsaturated fatty acids (PUFAs) have been reported to have various effects such as vasodilative and anti‐inflammatory, which myopia may be involved in. This study is to investigate the inhibitory effect of PUFAs on myopia progression. A lens‐induced myopia (LIM) model was prepared using C57B L6/J 3‐week‐old mice, which were equipped with a −30 diopter lens to the right eye. Chows containing two different ratios of n‐3/n‐6 PUFA were administered to the mice, and myopic shifts were confirmed in choroidal thickness, refraction, and axial length in the n‐3 PUFA‐enriched chow group after 5 weeks. To exclude the possibility that the other ingredients in the chow may have taken the suppressive effect, fat‐1 transgenic mice, which can produce n‐3 PUFAs endogenously, demonstrated significant suppression of myopia. To identify what elements in n‐3 PUFAs took effects on myopia suppression, enucleated eyes were used for targeted lipidomic analysis, and eicosapentaenoic acid (EPA) were characteristically distributed. Administration of EPA to the LIM model confirmed the inhibitory effect on choroidal thinning and myopia progression. Subsequently, to identify the elements and the metabolites of fatty acids effective on myopia suppression, targeted lipidomic analysis was performed and it demonstrated that metabolites of EPA were involved in myopia suppression, whereas prostaglandin E2 and 14,15‐dihydrotestosterone were associated with progression of myopia. In conclusion, EPA and its metabolites are related to myopia suppression and inhibition of choroidal thinning.

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“…Comorbid neuropsychiatric diseases were explored using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). Additional criteria of inclusion were as follows: (a) the absence of any other medical or comorbid psychiatric diseases; (b) a baseline verbal or full IQ >70 (28) or the respective scale for adults (WAIS-R) because subjects with high-functioning ASD were estimated to have a total IQ of at least 70 (29); and (c) no treatment with antidepressants, anxiolytic medications, or neuroleptics within 3 months prior to the initiation of the present study.…”

Section: Participantsmentioning

confidence: 99%

“…TAC levels in urine may be influenced by food intake (30,31). Furthermore, plasma fatty acid levels may be confounded by a prior dietary intake (28). To manage dietary intake, all 29 subjects received the "Japanese Food Guide" (32).…”

Section: Management Of Food Intake and Assessment Of Nutrient Intakementioning

confidence: 99%

Urinary and Plasma Antioxidants in Behavioral Symptoms of Individuals With Autism Spectrum Disorder

et al. 2021

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The balance between antioxidant capacity and oxidative stress-induced free radicals may be crucial in the pathophysiological development factor of autism spectrum disorder (ASD). We measured the following urinary and plasma biomarker levels of oxidative stress and antioxidants. As urinary biomarkers, (1) hexanoyl-lysine (HEL), which is a new biomarker of oxidative stress, (2) the total antioxidant capacity (TAC), and (3) 8-hydroxy-2′-deoxyguanosine (8-OHdG), as a product of oxidative modifications to DNA; and the plasma levels of (4) the antioxidant protein superoxide dismutase (SOD), which is the crucial defense again oxygen reactive species, and (5) transferrin and (6) ceruloplasmin, which are biomarkers of iron and copper neurotransmission and oxidant-antioxidant systems. We examined the relationship between these urinary and plasma biomarkers and behavioral symptoms in 19 individuals with ASD (mean age, 10.8 ± 5.2 years) and 10 age-matched healthy controls (mean age, 14.2 ± 7.0 years). Behavioral symptoms were estimated using the Aberrant Behavior Checklist (ABC). Urinary TAC levels were significantly lower, whereas urinary HEL levels were significantly increased in the ASD group as compared with the control group. The five ABC subscale and total scores were significantly raised in the autism group than in the control group. The results of a linear regression analysis revealed that plasma SOD levels may be a more accurate predictor of differences in ABC scores between individuals with ASD and control individuals. The present study firstly revealed the important findings that the cooperation between the urinary antioxidant TAC and plasma SOD levels may contribute to the ABC subscale scores of stereotypy. Urinary TAC activity and antioxidant protein SOD may be associated with incomplete mineral body store and antioxidant-related transcription factor and browning reactions. Consequently, a critical imbalance between TAC urinary levels and plasma SOD levels may be an important contributor to autistic behavioral symptoms.

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Dietary fatty acid intake, plasma fatty acid levels, and the risk of age-related macular degeneration (AMD): a dose–response meta-analysis of prospective cohort studies

Cited by 19 publications

References 76 publications

Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration

Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration

Lipidomic analysis revealed n‐3 polyunsaturated fatty acids suppressed choroidal thinning and myopia progression in mice

Urinary and Plasma Antioxidants in Behavioral Symptoms of Individuals With Autism Spectrum Disorder

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