Cardiovascular disease (CVD) is an overall term that comprises a number of related pathologies, these include peripheral arterial disease, cerebrovascular disease, coronary heart disease (CHD), venous thromboembolism, and rheumatic and congenital heart diseases. Fatty acids in the diet have been reported to affect CVD. The OPG/RANKL/RANK system appears to have a role in CVD outcomes. However, there have been few studies on the impact of dietgene interaction for effects of fatty acids consumption on the OPG/RANKL/ RANK system in CVD. This review focuses on the effects of fatty acids on OPG/ RANKL/RANK in CVD.
K E Y W O R D Scardiovascular disease, fatty acids, osteoprotegerin 1 | INTRODUCTION Cardiovascular disease (CVD) is a general term used for group of related pathologies that include cerebrovascular disease, coronary heart disease (CHD), peripheral arterial disease, venous thromboembolism, and rheumatic and congenital heart diseases. On global level, CVD accounts for 31% of mortality, most of which in the form of cerebrovascular accident and CHD. 1 According to WHO estimations, more than 75% of premature CVD is preventable and the amelioration of risk factors can help decrease the growing CVD burden on providers and individuals. 2 CVD prevention can reduce the rate of important cardiovascular outcomes, so can reduce premature disability and morbidity, on the other hand, can prolong survival and improve quality of life. 3 Preservation of a healthy population has a potential role for comprehensible reduction of economic burden of CVD among asymptomatic patients because the main part of the costs was related to CVD medication use. 4 The risk of incident stroke is 1.3 times higher in people working 55 hours or more per week than people J Cell Biochem. 2019;120:2774-2781. wileyonlinelibrary.com/journal/jcb 2774 |