Dietary fibre and blood pressure

Wright, Angela M.; Burstyn, P. G.; Gibney, Michael J.

doi:10.1136/bmj.2.6204.1541

Cited by 95 publications

(33 citation statements)

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“…For several decades, research has mainly focused on potentially adverse effects of excess sodium intake.' Dietary potassium has been inversely related to blood pressure in some,2-4 but not all156 cross-sectional studies, and supplementation has yielded conflicting results in clinical trials.7'8 Among other dietary constituents of protective effects, calcium,3'4'6 fiber, 9 and polyunsaturated fatty acids'0 have been suggested. Positive associations have been observed between alcohol intake and blood pressure."…”

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A prospective study of nutritional factors and hypertension among US women.

et al. 1989

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The relation of various nutritional factors with hypertension was examined prospectively among 58,218 predominantly white US female registered nurses, aged 34-59 years. In 1980, all women completed an independently validated dietary questionnaire. During 4 years of follow-up, 3,275 women reported a diagnosis of hypertension; the validity of the self-report was shown in a subsample. Age, relative weight, and alcohol consumption were the strongest predictors for the development of hypertension. Dietary calcium and magnesium had independent and significant inverse associations with hypertension. For women with a calcium intake of at least 800 mg/day, the relative risk of hypertension was 0.78 (95% confidence interval, 0.69-0.88) when compared with an intake of less than 400 mg/day. The relative risk for magnesium intake of 300 mg/day or more compared with an intake of less than 200 mg/day was 0.77 (95% confidence interval, 0.67-0.88). For women with high intakes of both calcium and magnesium compared with those having low intakes of both, the relative risk of hypertension was 0.65 (95% confidence interval, 0.53-0.80). No independent associations with hypertension were observed for intakes of potassium, fiber, and saturated and polyunsaturated fatty acids. These prospective findings add to the growing evidence to support the need for randomized trials to determine whether there is a protective role of dietary calcium and magnesium in the regulation of blood pressure. (Circulation 1989;80:1320-1327 T he search for nonpharmacologic approaches to prevent and control hypertension has led to interest in the effects of diet. For several decades, research has mainly focused on potentially adverse effects of excess sodium intake.' Dietary potassium has been inversely related to blood pressure in some,2-4 but not all156 cross-sectional studies, and supplementation has yielded conflicting results in clinical trials.7'8 Among other dietary constituents of protective effects, calcium,3'4'6 fiber,9 and polyunsaturated fatty acids'0 have been suggested. Positive associations have been observed between alcohol intake and blood pressure." The relation of dietary magnesium with blood pressure has received much less attention.With few exceptions,12"13 epidemiologic studies of diet and blood pressure have been cross-sectional2-6'9'14 rather than prospective. Although most studies excluded subjects on a prescribed diet, these studies still might have included hypertensive subjects who changed their diet after the diagnosis. Furthermore, most studies used a 24-hour recall to measure diet,3-5.9,14 which is generally a poor reflection of the usual intake of an individual. 15 In 1980, information on dietary intake over the preceding year was collected from a large cohort of US women. In the present study, we examine nutrient intake in relation to the development of hypertension during 4 years of follow-up. In addition to providing a very large study population, the potential for dietary change secondary to the diagnosis of high blood pres...

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A prospective study of nutritional factors and hypertension among US women.

et al. 1989

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“…9,13,14) A high intake of fiber may lower mean blood pressure in people with hypertension, 7) as well as in healthy subjects. 8) There are also many possible interactions between dietary fiber and drugs. 15) Dietary fiber reduces the bioavailability of some minerals, nutrients, and certain drugs, 9,16) although the interaction between dietary fiber and drugs remains poorly understood.…”

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“…1) Recently, many people have started to use dietary fiber supplements and to pay more attention to fiber in the diet, which can have many health benefits. 2,3) Dietary fiber reduces the risk of developing health problems, such as obesity, 4,5) hypertension, [6][7][8] constipation, 9,10) type 2 diabetes, 9,11,12) and hyperlipidemia. 9,13,14) A high intake of fiber may lower mean blood pressure in people with hypertension, 7) as well as in healthy subjects.…”

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“…The levels of free LO and TE tended to decrease with a higher concentration of sodium chloride in pH 1.2 fluid. These results suggest that it is important to pay attention to the possible interactions between ARBs and dietary fiber.Key words angiotensin II type 1 receptor blocker (ARB); dietary fiber; interaction Dietary fiber is defined as all dietary ingredients that are not digested by digestive enzymes in humans.1) Recently, many people have started to use dietary fiber supplements and to pay more attention to fiber in the diet, which can have many health benefits.2,3) Dietary fiber reduces the risk of developing health problems, such as obesity, 4,5) hypertension, [6][7][8] constipation, 9,10) type 2 diabetes, 9,11,12) and hyperlipidemia. 9,13,14) A high intake of fiber may lower mean blood pressure in people with hypertension, 7) as well as in healthy subjects.…”

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Effect of Dietary Fiber on the Level of Free Angiotensin II Receptor Blocker <i>in Vitro</i>

Iwazaki

Takahashi

Tamezane

et al. 2014

Biological & Pharmaceutical Bulletin

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The interaction between angiotensin II type 1 (AT1) receptor blockers (ARBs), such as losartan potassium (LO), candesartan (CA), and telmisartan (TE), and dietary fiber was studied as to the level of free ARB in vitro. When ARB was incubated with soluble (sodium alginate, pectin, and glucomannan) or insoluble (cellulose and chitosan) dietary fiber, the levels of free LO, TE, and CA decreased. This resulted only from mixing the dietary fiber with the ARBs and differed among the types of dietary fiber, and the pH and electrolytes in the mixture. The levels of free LO and TE tended to decrease with a higher concentration of sodium chloride in pH 1.2 fluid. These results suggest that it is important to pay attention to the possible interactions between ARBs and dietary fiber.Key words angiotensin II type 1 receptor blocker (ARB); dietary fiber; interaction Dietary fiber is defined as all dietary ingredients that are not digested by digestive enzymes in humans.1) Recently, many people have started to use dietary fiber supplements and to pay more attention to fiber in the diet, which can have many health benefits.2,3) Dietary fiber reduces the risk of developing health problems, such as obesity, 4,5) hypertension, [6][7][8] constipation, 9,10) type 2 diabetes, 9,11,12) and hyperlipidemia. 9,13,14) A high intake of fiber may lower mean blood pressure in people with hypertension, 7) as well as in healthy subjects. 8) There are also many possible interactions between dietary fiber and drugs. 15)Dietary fiber reduces the bioavailability of some minerals, nutrients, and certain drugs, 9,16) although the interaction between dietary fiber and drugs remains poorly understood.Patients with hypertension will generally be treated with various antihypertensive drugs. In recent years, numerous orally active, selective angiotensin II type 1 (AT1)-receptor blockers (ARBs) have come into clinical use.15) Losartan potassium (LO), candesartan (CA), and telmisartan (TE) are AT1-selective ARBs (Fig. 1) currently being developed for the treatment of hypertension and heart failure.Dietary fiber adsorbs drugs, thereby altering the quantity of the free from of the drugs.2,17) Thus, it is important to understand how dietary fiber interacts with ARBs. The bioavailability of orally administered drugs depends on their absorption, which is affected by several factors, such as the pK a of a drug, the pH at the absorptive site, and the gastric emptying rate. Within the gastrointestinal tract, dietary fiber behaves as a polymer matrix with variable physicochemical properties, including susceptibility to bacterial fermentation, water-holding capacity, cation-exchange function, and adsorptive function.9) The absorption of a certain drug or substance, when administered concomitantly with guar gum and other dietary fibers, may be modified by altered gastric emptying, lower diffusion from viscous matrices than from solutions, and cholestyramine-like actions.16) The hypocholesterolemic activity of lovastatin decreases in the presence of oat bran or pectin...

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“…20 De igual manera, en algunos estudios se ha demostrado que el incremento en la ingestión de fibra dietética provoca una disminución en la presión arterial; 21 no obstante, a pesar de esa evidencia el tema aún es controversial ya que en otros estudios no se ha encontrado ninguna asociación. 22 El impacto de los cambios dietéticos sobre la presión arterial se ha estudiado ampliamente en sujetos hipertensos y muy poco en normotensos; se ha informado que la reducción en el consumo de sodio en sujetos normotensos de 3.6 a 1.5 g/d provoca una disminución de hasta 2 mmHg en la presión sistólica y diastólica.…”

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Consumo de fibra dietética, sodio, potasio y calcio y su relación con la presión arterial en hombres adultos normotensos

Ballesteros-Vásquez¹,

Cabrera-Pacheco²,

Saucedo-Tamayo³

et al. 1998

Salud pública Méx

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Consumo de fibra dietética, sodio, potasio y calcio y su relación con la presión arterial en hombres adultos normotensosMartha Nydia Ballesteros-Vásquez, Q.B., M. en C., (1) Rosa María Cabrera-Pacheco, Q.B., M. en C.,María del Socorro Saucedo-Tamayo, Lic. en Enf., (1) María Isabel Grijalva-Haro, Q.B., M. en C.(1)(1) Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, Sonora, México. ResumenObjetivo. Evaluar el efecto del consumo de fibra dietética, energía, sodio, potasio y calcio sobre la presión arterial de un grupo de adultos normotensos, tomando en cuenta indicadores tales como la edad, el sexo, la actividad física y la obesidad. Material y métodos. Se evaluaron 38 sujetos del sexo masculino de 30 a 45 años de edad, normotensos, aparentemente sanos y residentes de la ciudad de Hermosillo, Sonora, México. Se midió la presión arterial y se realizó una evaluación dietética, antropométrica y de actividad física. Resultados. La dieta resultó ser alta en fibra y en grasa. El sodio estaba 56% por arriba de la recomendación en 87% de los casos y fue la variable que más efecto mostró sobre la presión diastólica. De los sujetos estudiados, 36.9% tenían sobrepeso y obesidad, y se encontró una asociación significativa entre el índice de masa corporal y la presión diastólica y sistólica. Conclusiones. Existe una asociación significativa entre la hipertensión arterial y el alto consumo de sodio, el sobrepeso y la obesidad en sujetos normotensos.Palabras clave: presión sanguínea; fibra en la dieta; sodio en la dieta; potasio en la dieta; calcio en la dieta; México

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Dietary fibre and blood pressure

Cited by 95 publications

References 10 publications

A prospective study of nutritional factors and hypertension among US women.

A prospective study of nutritional factors and hypertension among US women.

Effect of Dietary Fiber on the Level of Free Angiotensin II Receptor Blocker <i>in Vitro</i>

Consumo de fibra dietética, sodio, potasio y calcio y su relación con la presión arterial en hombres adultos normotensos

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