Dietary fish, n-3 polyunsaturated fatty acid consumption, and depression risk in Japan: a population-based prospective cohort study

Matsuoka, Yutaka; Sawada, Norie; Mimura, Masaru; Shikimoto, Ryo; Nozaki, Shinichi; Hamazaki, Kei; Uchitomi, Yosuke; Tsugane, Shoichiro

doi:10.1038/tp.2017.206

Cited by 71 publications

(84 citation statements)

References 32 publications

(36 reference statements)

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“…Similar to the above cross-sectional data, prospective studies on the relationship between fatty acids and depression show substantial heterogeneity (Lucas et al 2011;Grossoetal.2014;Matsuoka et al 2017). Although other fatty acid classes have also been prospectively studied, most studies again focused on omega-3 fatty acid concentrations or intake.…”

Section: Longitudinal Observational Studiesmentioning

confidence: 80%

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Mocking

Assies

Ruhé

et al. 2018

J of Inher Metab Disea

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Continuous research into the pathophysiology of psychiatric disorders, such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and schizophrenia, suggests an important role for metabolism. This narrative review will provide an upto-date summary of how metabolism is thought to be involved in the pathophysiology of these psychiatric disorders. We will focus on (I) the important role of fatty acids in these metabolic alterations, (II) whether fatty acid alterations represent epiphenomena or risk factors, and (III) similarities and dissociations in fatty acid alterations between different psychiatric disorders. (Historical) epidemiological evidence links fatty acid intake to psychiatric disorder prevalence, corroborated by altered fatty acid concentrations measured in psychiatric patients. These fatty acid alterations are connected with other concomitant pathophysiological mechanisms, including biological stress (hypothalamic-pituitary-adrenal (HPA)-axis and oxidative stress), inflammation, and brain network structure and function. Metabolomics and lipidomics studies are underway to more deeply investigate this complex network of associated neurometabolic alterations. Supplementation of fatty acids as disease-modifying nutraceuticals has clinical potential, particularly add-on eicosapentaenoic acid (EPA) in depressed patients with markers of increased inflammation. However, by interpreting the observed fatty acid alterations as partly (mal)adaptive phenomena, we attempt to nuance translational expectations and provide new clinical applications for these novel neurometabolic insights, e.g., to predict treatment response or depression recurrence. In conclusion, placing fatty acids in context can contribute to further understanding and optimized treatment of psychiatric disorders, in order to diminish their overwhelming burden of disease.

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Section: Longitudinal Observational Studiesmentioning

confidence: 80%

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Mocking

Assies

Ruhé

et al. 2018

J of Inher Metab Disea

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“…The characteristics of prospective studies included in the meta‐analysis are presented in Table . The smallest sample size was 1181 participants (Matsuoka et al, ), while the largest sample size was 54 632 participants (Lucas et al, ). Of the 10 prospective studies, 4 studies examined the association of both fish and omega‐3 fatty acid intake and depression (Colangelo et al, ; Hakkarainen et al, ; Lucas et al, ; Matsuoka et al, ), 4 studies were focused only on fish consumption (Li et al, ; Mihrshahi et al, ; Smith et al, ; Tsai et al, ), and 2 studies were focused only on omega‐3 fatty acid intake (Kesse‐Guyot et al, ; Persons et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…We calculated the RR for 1 serving/week increment of fish consumption and 500 mg/day increment of omega-3 fatty acid intake. For the study that reported results for fish consumption in terms of g/day only (Matsuoka et al, 2017), we supposed that 100 g of fish equals 1 serving as has been done in a previous study of fish consumption (Bouzan et al, 2005;Guevel, Sirot, Volatier, & Leblanc, 2008;Wu et al, 2015). For the analysis of fish consumption, 3 studies were excluded due to insufficient information on the number of cases, number of controls, and exposure categories (Colangelo et al, 2009;Hakkarainen et al, 2004;Lucas et al, 2011), and 3 studies with fewer than 3 exposure categories were also excluded (Mihrshahi et al, 2015;Smith et al, 2014;Tsai et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…After excluding duplicated and irrelevant articles, 10 prospective studies met our inclusion criteria. The 10 prospective studies included 109 764 participants, with 6672 cases (Colangelo et al, 2009;Hakkarainen et al, 2004;Kesse-Guyot et al, 2012;Li et al, 2011;Lucas et al, 2011;Matsuoka et al, 2017;Mihrshahi et al, 2015;Persons et al, 2014;Smith et al, 2014;Tsai et al, 2012) (Figure 1). The characteristics of prospective studies included in the meta-analysis are presented in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The characteristics of prospective studies included in the meta-analysis are presented in Table 1. The smallest sample size was 1181 participants (Matsuoka et al, 2017), while the largest sample size was 54 632 participants (Lucas et al,…”

Section: Study Characteristicsmentioning

confidence: 99%

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Fish consumption and risk of depression: Epidemiological evidence from prospective studies

Yang

Kim

2018

Asia-Pacific Psychiatry

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Introduction The evidence on the association of fish or omega‐3 fatty acid intake with depression is inconsistent. We conducted a systematic review and meta‐analysis of prospective cohort studies to examine this association. Methods Database searches in PubMed and Web of Science were conducted to identify relevant articles published up to April 2018, which were supplemented by hand‐searches of reference lists of the retrieved articles. Using a random‐effects model, we calculated pooled relative risks (RR) of depression in relation to consumption of fish or omega‐3 fatty acids after adjusting for potential confounders. Results A total of 10 prospective cohort studies with 6672 cases of depression among 109 764 participants were included in the meta‐analysis. The pooled adjusted RR of depression for the highest vs lowest category of fish consumption was 0.89 (95% CI: 0.80‐0.99). The pooled adjusted RR of depression for the highest vs lowest category of omega‐3 intake was 0.87 (95% CI: 0.74‐1.04). In the dose‐response analysis, the pooled adjusted RRs for an increment of 1 serving/week of fish consumption and 500 mg/day of omega‐3 fatty acid intake were 0.89 (95% CI: 0.75‐1.04) and 0.99 (95% CI: 0.94‐1.04), respectively. There was no evidence of heterogeneity. Discussion Our findings provide quantitative evidence for a modest inverse association between fish or omega‐3 fatty acid intake and risk of depression, especially in women. These findings from the observational studies need to be confirmed through large randomized clinical trials of fish consumption or omega‐3 fatty acid intake and risk of depression.

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The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review

Al Shamsi,

Rainey‐Smith,

Gardener

et al. 2024

Molecular Nutrition Food Res

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Purpose of ReviewThis narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD).Recent FindingsAD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, along with adherence to dietary patterns like the Mediterranean diet, which includes multiple beneficial dietary factors.SummaryThe investigation of dietary factors in the prevention of depression and AD is a comparatively young field of research. Comprehensive highly characterised longitudinal datasets and advanced analytical approaches are required to further examine the complex relationship between diet, depression, and AD. There is a critical need for more research in this area to develop effective preventive strategies aimed at maintaining mental and physical health with advancing age.

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Dietary fish, n-3 polyunsaturated fatty acid consumption, and depression risk in Japan: a population-based prospective cohort study

Cited by 71 publications

References 32 publications

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Fish consumption and risk of depression: Epidemiological evidence from prospective studies

The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review

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