Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats

Rossi, Andrea; Lombardo, Yolanda B.; Lacorte, Jean‐Marc; Chicco, Adriana; Rouault, Christine; Slama, G.; Rizkalla, Salwa W.

doi:10.1152/ajpregu.00846.2004

Cited by 151 publications

(178 citation statements)

References 51 publications

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“…Our data suggest that fish oil feeding resulted in a decrease of WAT and body weight and improved insulin sensitivity in female KK mice. Rossi et al reported that shifting the source of fat to fish oil for 2 months increased plasma levels of both leptin and adiponectin in rats 25) . Haluzik et al reported that fenofibrate treatment did not increase serum adiponectin in mice fed a carbohydrate diet 26) .…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity Effect of Fish Oil and Fish Oil-Fenofibrate Combination in Female KK Mice

Arai

Kim

Chiba

et al. 2009

JAT

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Aim:The aim of our study is to elucidate the effects of EPA-or DHA-rich fish oil, and of the latter plus fenofibrate, on lipid metabolism in female KK mice. Methods: Female KK mice were fed purified experimental diets containing lard/safflower oil (4:6, Lard/SO), EPA-rich fish oil (EPA), DHA-rich fish oil (DHA), or DHA-rich fish oil plus 0.2% (w/w) fenofibrate (DHA FF) for 8 weeks. At the end of the experiments, we measured levels of plasma lipids, hepatic triglycerides, and cholesterol, as well as the hepatic mRNA expression of lipogenic and lipidolytic genes. Results: The final body weight of EPA-and DHA-fed groups was significantly lower than that of the Lard/SO-fed group, and that of the DHA FF-fed group was the lowest. All three fish oil treatments significantly reduced plasma insulin levels. Hepatic lipid levels significantly decreased in all three of these groups compared with the Lard/SO-fed group. Plasma adiponectin increased in both the EPAand DHA-fed groups, but the increase was suppressed in the DHA FF-fed group. Hepatocytes of Lard/SO-fed mice were filled with numerous fat droplets, but fat accumulation was inhibited in both EPA-and DHA-fed mice and was significantly prevented by fenofibrate treatment. SREBP-1c mRNA levels were decreased by about half in EPA-and DHA-fed mice compared with Lard/SO-fed mice. FAS, Insig-1, HMG-CoA reductase, and LDL-receptor mRNA levels also markedly decreased in both EPA-and DHA-fed mice, but there was no additional decrease in DHA FF fed mice. Fenofibrate treatment significantly induced mRNA expression of AOX and UCP-2, but not of PPAR . Conclusion: These data suggest that fish oil inhibited body weight gain and exhibited an anti-obesity effect through the inhibition of lipid synthesis in female KK mice. Furthermore, fenofibrate treatment markedly inhibited body weight gain by the induction of fatty acid oxidation. Plasma adiponectin levels did not increase in mice fed DHA-rich fish oil with fenofibrate, although white adipose tissue (WAT) weight significantly decreased. We considered that adiponectin sensitivity increased more in mice fed DHA-rich fish oil with fenofibrate than in mice fed DHA-rich fish oil alone.

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Section: Discussionmentioning

confidence: 99%

Anti-Obesity Effect of Fish Oil and Fish Oil-Fenofibrate Combination in Female KK Mice

Arai

Kim

Chiba

et al. 2009

JAT

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“…These increases in adiponectin may subsequently upregulate genes involved in fatty acid oxidation (Yamauchi et al, 2002;Rossi et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Nutritional intervention to reduce the n−6/n−3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects

et al. 2007

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Background/Objectives: Consumption of nÀ3 polyunsaturated fatty acids (PUFA) has a favourable impact on inflammation and cardiovascular disease. However, the Western diet is characterized by a low nÀ3 PUFA intake and an imbalance in the nÀ6/ nÀ3 PUFA ratio. Study the effect 10-week of diet modification to decrease the nÀ6/nÀ3 PUFA ratio on cardiovascular risk factors and resting energy expenditure. Conclusion: A decreased nÀ6/nÀ3 PUFA ratio can be achieved with simple dietary counselling, resulting in multiple, potentially favourable effects on the metabolic and inflammatory profiles.

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“…Leptin concentration, on the other hand, was inversely associated with membrane eicosapentaenoic and docosahexaenoic acids. Recently, leptin-lowering effect of long-chain omega-3 fatty acids (fish oil) has been demonstrated in dietinduced rodent model of obesity (Rossi et al, 2005;Selenscig et al, 2010). Plasma leptin concentration is closely linked with fat mass and fat mass itself can be modulated by longchain omega-3 fatty acids as we have previously observed (Aurora et al, 2005).…”

Section: Discussionmentioning

confidence: 55%

Relationship between red cell membrane fatty acids and adipokines in individuals with varying insulin sensitivity

et al. 2011

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Background/Objectives: Plasma leptin and adiponectin, and membrane phospholipid fatty acid composition are implicated into the mechanism of insulin resistance but no clear pattern has emerged. Hence, this study examined these variables in subjects presenting to the diabetic clinic for a diagnostic glucose tolerance test. Subjects/Methods: Body composition, glucose, glycated hemoglobin, insulin, leptin, adiponectin, and red cell and plasma phospholipid fatty acids were assessed from 42 normal and 28 impaired glucose tolerant subjects. Insulin sensitivity was determined by homeostatic model assessment. Results: The plasma phosphatidylcholine fatty acid composition of the impaired glucose tolerant subjects was similar to that of normal subjects. However, the impaired glucose tolerant subjects had significantly lower linoleic (Po0.05), eicosapentaenoic (Po0.05) and docosahexaenoic (Po0.01) acids in the red cell phosphatidylcholine and phosphatidylethanolamine compared with the normal subjects. Moreover, red cell phosphatidylcholine docosahexaenoic acid correlated positively with adiponectin (r ¼ 0.290, Po0.05) but negatively with leptin (r ¼ À0.252, Po0.05), insulin (r ¼ À0.335, Po0.01) and insulin resistance (r ¼ À0.322, Po0.01). Plasma triglycerides, leptin and glucose combined predicted about 60% of variation in insulin level whereas insulin was the only component that predicted the membrane fatty acids. Conclusions: We postulate that membrane phospholipids fatty acids have an indirect role in determining insulin concentration but insulin has a major role in determining membrane fatty acid composition.

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Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats

Cited by 151 publications

References 51 publications

Anti-Obesity Effect of Fish Oil and Fish Oil-Fenofibrate Combination in Female KK Mice

Anti-Obesity Effect of Fish Oil and Fish Oil-Fenofibrate Combination in Female KK Mice

Nutritional intervention to reduce the n−6/n−3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects

Relationship between red cell membrane fatty acids and adipokines in individuals with varying insulin sensitivity

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