Dietary fish oil prevents vascular dysfunction and oxidative stress in hyperinsulinemic rats

Nyby, Michael D.; Matsumoto, Keiko; Yamamoto, Kei; Abedi, Karolin; Eslami, Pirooz; Hernández, Gustavo Pastelín; Smutko, Victoria; Berger, Morris E.; Tuck, Michael L.

doi:10.1016/j.amjhyper.2004.08.030

Cited by 51 publications

(28 citation statements)

References 38 publications

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“…Therefore, as a potential AD-relevant model, we chose insulin-resistant rats on a high fructose corn syrup diet. Dietary fish oil has been reported to prevent oxidative stress in this model (Nyby et al, 2005). We observed that supplementation with 2.2% fish oil diet containing 0.24% DHA and 0.36% EPA for 8 weeks, significantly increased LR11 protein levels in 3-to 4-month-old insulin resistant rats compared with the control fructose-fed group (**p Ͻ 0.01).…”

Section: Dha Increases Lr11 Protein Levels In Human Neural Sh-sy5y Cesupporting

confidence: 51%

Omega-3 Fatty Acid Docosahexaenoic Acid Increases SorLA/LR11, a Sorting Protein with Reduced Expression in Sporadic Alzheimer's Disease (AD): Relevance to AD Prevention

Teter²,

Ubeda³

et al. 2007

J. Neurosci.

105

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Environmental and genetic factors, notably ApoE4, contribute to the etiology of late-onset Alzheimer's disease (LOAD). Reduced mRNA and protein for an apolipoprotein E (ApoE) receptor family member, SorLA (LR11) has been found in LOAD but not early-onset AD, suggesting that LR11 loss is not secondary to pathology. LR11 is a neuronal sorting protein that reduces amyloid precursor protein (APP) trafficking to secretases that generate ␤-amyloid (A␤). Genetic polymorphisms that reduce LR11 expression are associated with increased AD risk. However these polymorphisms account for only a fraction of cases with LR11 deficits, suggesting involvement of environmental factors. Because lipoprotein receptors are typically lipid-regulated, we postulated that LR11 is regulated by docosahexaenoic acid (DHA), an essential -3 fatty acid related to reduced AD risk and reduced A␤ accumulation. In this study, we report that DHA significantly increases LR11 in multiple systems, including primary rat neurons, aged non-Tg mice and an aged DHA-depleted APPsw AD mouse model. DHA also increased LR11 in a human neuronal line. In vivo elevation of LR11 was also observed with dietary fish oil in young rats with insulin resistance, a model for type II diabetes, another AD risk factor. These data argue that DHA induction of LR11 does not require DHA-depleting diets and is not age dependent. Because reduced LR11 is known to increase A␤ production and may be a significant genetic cause of LOAD, our results indicate that DHA increases in SorLA/LR11 levels may play an important role in preventing LOAD.

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Section: Dha Increases Lr11 Protein Levels In Human Neural Sh-sy5y Cesupporting

confidence: 51%

Omega-3 Fatty Acid Docosahexaenoic Acid Increases SorLA/LR11, a Sorting Protein with Reduced Expression in Sporadic Alzheimer's Disease (AD): Relevance to AD Prevention

Teter²,

Ubeda³

et al. 2007

J. Neurosci.

105

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“…Diets high in fish oils prevent hyperinsulinemia, hypertriglyceridemia, and hypertension in fructose-and dexamethasone-induced hypertensive rat models [184][185][186]. Increased PUFA intake is associated with a reduction of reactive oxygen species and an increase in antioxidants during hypertension [187][188][189]. Dietary fish oils can prevent LVH in transgenic mice with a carnitine transporter mutation, which was attributed to modified diacylglycerol composition and resultant inhibition of PKC activation [190].…”

Section: Polyunsaturated Fats and Fish Oilsmentioning

confidence: 97%

Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy

Sharma

Okere

Duda

et al. 2007

Cardiovascular Research

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Currently, a high carbohydrate/low fat diet is recommended for patients with hypertension; however, the potentially important role that the composition of dietary fat and carbohydrate plays in hypertension and the development of pathological left ventricular hypertrophy (LVH) has not been well characterized. Recent studies demonstrate that LVH can also be triggered by activation of insulin signaling pathways, altered adipokine levels, or the activity of peroxisome proliferator-activated receptors (PPARs), suggesting that metabolic alterations play a role in the pathophysiology of LVH. Hypertensive patients with high plasma insulin or metabolic syndrome have a greater occurrence of LVH, which could be due to insulin activation of the serine-threonine kinase Akt and its downstream targets in the heart, resulting in cellular hypertrophy. PPARs also activate cardiac gene expression and growth and are stimulated by fatty acids and consumption of a high fat diet. Dietary intake of fats and carbohydrate and the resultant effects of plasma insulin, adipokine, and lipid concentrations may affect cardiomyocyte size and function, particularly in the setting of chronic hypertension. This review discusses potential mechanisms by which dietary carbohydrates and fats ca affect cardiac growth, metabolism, and function, mainly in the context of pressure overload-induced LVH.

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“…The CONT+CAP and FFR +CAP were thereafter given drinking water containing 500 mg/L captopril (ICN Chemicals, Costa Mesa, USA). Systolic blood pressure was measured weekly using a tail-cuff method with an optical sensor (IITC, Woodland Hills, USA) as previously described (2,13). Measures were taken to reduce stress in the rats while their blood pressures were determined.…”

Section: Animalsmentioning

confidence: 99%

“…Feeding normal rats a high-fructose diet induces insulin resistance, hypertension, dyslipidemia and vascular dysfunction (1,2). Although the fructose-fed rat (FFR) model exhibits many metabolic disorders, the cause of hypertension in these animals is not known.…”

Section: Introductionmentioning

confidence: 99%

Vascular Angiotensin Type 1 Receptor Expression Is Associated with Vascular Dysfunction, Oxidative Stress and Inflammation in Fructose-Fed Rats

et al. 2007

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This study determined whether or not oxidative stress and vascular dysfunction in fructose-induced hyperinsulinemic rats are associated with activation of the vascular renin-angiotensin system (RAS). Four groups of rats were used. CONT rats were fed normal rat chow, CONT + CAP were fed normal rat chow and given 500 mg/L captopril in their drinking water, fructose-fed rats (FFR) were fed a high-fructose diet and

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Dietary fish oil prevents vascular dysfunction and oxidative stress in hyperinsulinemic rats

Abstract: These results demonstrate that dietary fish oil prevents vascular dysfunction in FFR and that this effect of fish oil is associated with increased eNOS expression and decreased oxidative stress.

Cited by 51 publications

References 38 publications

Omega-3 Fatty Acid Docosahexaenoic Acid Increases SorLA/LR11, a Sorting Protein with Reduced Expression in Sporadic Alzheimer's Disease (AD): Relevance to AD Prevention

Omega-3 Fatty Acid Docosahexaenoic Acid Increases SorLA/LR11, a Sorting Protein with Reduced Expression in Sporadic Alzheimer's Disease (AD): Relevance to AD Prevention

Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy

Vascular Angiotensin Type 1 Receptor Expression Is Associated with Vascular Dysfunction, Oxidative Stress and Inflammation in Fructose-Fed Rats

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