Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice

Yano, Shunsuke; Umeda, Daisuke; Yamashita, Tatsunori; Ninomiya, Yu; Sumida, Mami; Fujimura, Yoshinori; Yamada, Koji; Tachibana, Hirofumi

doi:10.1007/s00394-007-0658-7

Cited by 66 publications

(49 citation statements)

References 18 publications

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“…As IL-4 is the major inducer for class-switching to IgE biosynthesis in B lymphocytes, the decrease in serum IgE in cocoa-fed rats should be associated with lower IL-4 production. It is noteworthy that although some authors reported low levels of IL-4 after flavonoid treatment [30,31] others did not find any difference [12]. On the other hand, previous studies with a similar cocoa diet in rats noted a decrease of IL-4 production in spleen [16,18] but not in MLN cells [18].…”

Section: Discussionmentioning

confidence: 88%

“…In first case, a leaf extract rich in the flavonol myricitrin decreased total IgE in an allergy model in transgenic mice [29]. The flavones chrysin and apigenin suppressed total IgE concentrations whereas IgG, IgM and IgA concentrations were not affected [30] but later studies show that apigenin in a mice model of atopic dermatitis decreased serum total IgG1 and IgE concentrations, without modifying significantly specific antibodies, and ameliorated the development of skin lesions [12].…”

Section: Discussionmentioning

confidence: 99%

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A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Abril-Gil¹,

Massot-Cladera²,

Pérez-Cano³

et al. 2012

Pharmacological Research

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Previous studies in young rats reported the impact of cocoa intake on healthy immune status and allow suggesting it may have a role in the prevention of some immune-mediated diseases. The aim of this study was to ascertain the effect of a cocoa diet in a model of allergy in young rats. Three-week-old Brown Norway rats were immunized by i.p. injection of ovalbumin (OVA) with alum as adjuvant and Bordetella pertussis toxin. During the next 4 weeks rats received either a cocoa diet (containing 0.2% polyphenols, w/w) or a standard diet. Animals fed a standard diet showed high concentrations of anti-OVA IgG1, IgG2a, IgG2b and high anti-OVA IgE titres, which is the antibody involved in allergic response. In contrast, animals fed a cocoa diet showed significantly lower concentrations of anti-OVA IgG1 and IgG2a antibodies. Interestingly, the cocoa diet prevented anti-OVA IgE synthesis and decreased total serum IgE concentration. Analysis of cytokine production in lymph node cells at the end of the study revealed that, in this compartment, the cocoa diet decreased the tumor necrosis factor (TNF) -α and the interleukin (IL) -10 secretion but not IL-4 production. In conclusion, a cocoa-enriched diet in young rats produces an immunomodulatory effect that prevents anti-allergen IgE synthesis, suggesting a potential role for cocoa flavonoids in the prevention or treatment of allergic diseases. 3

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

A diet enriched with cocoa prevents IgE synthesis in a rat allergy model

Abril-Gil¹,

Massot-Cladera²,

Pérez-Cano³

et al. 2012

Pharmacological Research

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“…The mice received OVA (100 lg body -1 ) with an alum adjuvant (LSL Inc., Japan) by intraperitoneal (i.p.) injection on days 7 and 21 to elicit a specific IgE response (Yano et al 2007). After 5 days of the second OVA induction (day 26), blood and splenocytes were collected.…”

Section: Cells and Cell Culturementioning

confidence: 99%

Immunostimulatory effects of collagen from jellyfish in vivo

et al. 2011

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We focused on the biological activity of the collagen extracts obtained from the giant edible jellyfish, Nemopilema nomurai. Jellyfish collagen extracts stimulates the production of immunoglobulins (Igs) and cytokines by human hybridoma cells and human peripheral blood lymphocytes. Therefore, we examined the immunoregulatory function of jellyfish collagen extracts in mice. Intake of jellyfish collagen extracts facilitated the Ig production activity of lymphocytes from spleen and Peyer's patch. Furthermore, the levels of Igs in the serum clearly increased after the administration of jellyfish collagen extracts. Intake of bovine collagen from Achilles' tendon also activated lymphocytes activity in mice. The activity of total and antigen-specific Ig production in splenocytes from OVA-challenged mice was also enhanced by collagen intake. However, the total and OVA-specific IgE levels in the serum were not affected by the collagen intake. These results suggested that jellyfish collagen extracts stimulates an immune response in vivo, without inducing allergic complications.

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“…It was also found that nobiletin, a polymethoxyflavonoid, when given intraperitoneally to OVA-sensitized rats at a dose of 1.5 or 5 mg/kg, reduced OVA-induced increases in eosinophils and eotaxin expression (Wu et al, 2006). In subsequent investigations, flavonoids such as quercetin, isoquercitrin, rutin, 3-O-methylquercetin 5,7,3',4'-O-tetraacetate, narirutin, apigenin, luteolin, sulfuretin, hesperdin, fisetin and kaempferol have been shown to suppress responses in various types of allergic animals (Makino et al, 2001;Fernandez et al, 2005;Rogerio et al, 2007;Jung et al, 2007;Jiang et al, 2007;Funaguchi et al, 2007;Yano et al, 2007;Cruz et al, 2008;Choi et al, 2009;Li et al, 2010;Leemans et al, 2010;Shishebor et al, 2010;Kim et al, 2011;Wu et al, 2011;Gong et al, 2012).…”

Section: Efficacy Of Flavonoids In Allergic Modelsmentioning

confidence: 98%